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Hidden antibiotics: Where to uncover?

Maarten De Mol (UGent) , Nico Snoeck (UGent) , Sofie De Maeseneire (UGent) and Wim Soetaert (UGent)
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Abstract
The struggle of humans versus pathogens is a never ending battle. Since the discovery of antibiotics humans have tipped the scales in their favour, but today bacteria are nullifying this advantage by developing resistance mechanisms against these molecules. The plethora of different antibiotics active against pathogens is shrinking while the discovery of new molecules is arduous. Especially the development of drugs active against Gram− pathogens continues slowly. New strategies to discover novel, potent antibiotics are hence needed. Adopting the optimistic view of technological singularity, innovative and disruptive approaches are required and hence proposed to lift the current conundrum. In this review, questions are answered on where and how to look for new natural product hit molecules with antibacterial activity, on how the field of synthetic biology can aid the contemporary pharmaceutical challenge and whether we are ready to make the transition towards other approaches, such as narrow-spectrum antibiotics and phage therapy.
Keywords
Hidden Antibiotics, Habitat Profiling, Natural Product, Genome Mining, Synthetic Biology, Nagoya, Drug hit, LoDDaD

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Citation

Please use this url to cite or link to this publication:

Chicago
De Mol, Maarten, Nico Snoeck, Sofie De Maeseneire, and Wim Soetaert. 2018. “Hidden Antibiotics: Where to Uncover?” Biotechnology Advances.
APA
De Mol, M., Snoeck, N., De Maeseneire, S., & Soetaert, W. (2018). Hidden antibiotics: Where to uncover? Biotechnology Advances.
Vancouver
1.
De Mol M, Snoeck N, De Maeseneire S, Soetaert W. Hidden antibiotics: Where to uncover? Biotechnology Advances. Elsevier BV; 2018;
MLA
De Mol, Maarten et al. “Hidden Antibiotics: Where to Uncover?” Biotechnology Advances (2018): n. pag. Print.
@article{8581261,
  abstract     = {The struggle of humans versus pathogens is a never ending battle. Since the discovery of antibiotics humans have tipped the scales in their favour, but today bacteria are nullifying this advantage by developing resistance mechanisms against these molecules. The plethora of different antibiotics active against pathogens is shrinking while the discovery of new molecules is arduous. Especially the development of drugs active against Gram\ensuremath{-} pathogens continues slowly. New strategies to discover novel, potent antibiotics are hence needed. Adopting the optimistic view of technological singularity, innovative and disruptive approaches are required and hence proposed to lift the current conundrum. In this review, questions are answered on where and how to look for new natural product hit molecules with antibacterial activity, on how the field of synthetic biology can aid the contemporary pharmaceutical challenge and whether we are ready to make the transition towards other approaches, such as narrow-spectrum antibiotics and phage therapy.},
  author       = {De Mol, Maarten and Snoeck, Nico and De Maeseneire, Sofie and Soetaert, Wim},
  issn         = {0734-9750},
  journal      = {Biotechnology Advances},
  language     = {eng},
  publisher    = {Elsevier BV},
  title        = {Hidden antibiotics: Where to uncover?},
  url          = {http://dx.doi.org/10.1016/j.biotechadv.2018.10.008},
  year         = {2018},
}

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