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The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte Scott (UGent) , Wouter T'Jonck (UGent) , Liesbet Martens (UGent) , Helena Todorov (UGent) , Dorine Sichien (UGent) , Bieke Soen (UGent) , Johnny Bonnardel (UGent) , Sofie De Prijck (UGent) , Niels Vandamme (UGent) , Robrecht Cannoodt (UGent) , et al.
(2018) IMMUNITY. 49(2). p.312-325
Author
Organization
Abstract
Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages remain largely unknown. The transcription factor ZEB2 is best described for its role in epithelial to mesenchymal transition; however, its role within the immune system is only now being elucidated. We show here that Zeb2 expression is a conserved feature of macrophages. Using Clec4f-cre, Itgax-cre, and Fcgr1-cre mice to target five different macrophage populations, we found that loss of ZEB2 resulted in macrophage disappearance from the tissues, coupled with their subsequent replenishment from bone-marrow precursors in open niches. Mechanistically, we found that ZEB2 functioned to maintain the tissue-specific identities of macrophages. In Kupffer cells, ZEB2 achieved this by regulating expression of the transcription factor LXR alpha, removal of which recapitulated the loss of Kupffer cell identity and disappearance. Thus, ZEB2 expression is required in macrophages to preserve their tissue-specific identities.
Keywords
COLONY-STIMULATING FACTOR, DENDRITIC CELLS, RESIDENT MACROPHAGES, IN-VIVO, MOUSE, HOMEOSTASIS, MONOCYTES, MICE, DIFFERENTIATION, EXPRESSION

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MLA
Scott, Charlotte, et al. “The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.” IMMUNITY, vol. 49, no. 2, 2018, pp. 312–25, doi:10.1016/j.immuni.2018.07.004.
APA
Scott, C., T’Jonck, W., Martens, L., Todorov, H., Sichien, D., Soen, B., … Guilliams, M. (2018). The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages. IMMUNITY, 49(2), 312–325. https://doi.org/10.1016/j.immuni.2018.07.004
Chicago author-date
Scott, Charlotte, Wouter T’Jonck, Liesbet Martens, Helena Todorov, Dorine Sichien, Bieke Soen, Johnny Bonnardel, et al. 2018. “The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.” IMMUNITY 49 (2): 312–25. https://doi.org/10.1016/j.immuni.2018.07.004.
Chicago author-date (all authors)
Scott, Charlotte, Wouter T’Jonck, Liesbet Martens, Helena Todorov, Dorine Sichien, Bieke Soen, Johnny Bonnardel, Sofie De Prijck, Niels Vandamme, Robrecht Cannoodt, Wouter Saelens, Bavo Vanneste, Wendy Toussaint, Pieter De Bleser, Nozomi Takahashi, Peter Vandenabeele, Sandrine Henri, Clare Pridans, David A Hume, Bart Lambrecht, Patrick De Baetselier, Simon WF Milling, Jo A Van Ginderachter, Bernard Malissen, Geert Berx, Alain Beschin, Yvan Saeys, and Martin Guilliams. 2018. “The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.” IMMUNITY 49 (2): 312–325. doi:10.1016/j.immuni.2018.07.004.
Vancouver
1.
Scott C, T’Jonck W, Martens L, Todorov H, Sichien D, Soen B, et al. The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages. IMMUNITY. 2018;49(2):312–25.
IEEE
[1]
C. Scott et al., “The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages,” IMMUNITY, vol. 49, no. 2, pp. 312–325, 2018.
@article{8581148,
  abstract     = {{Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages remain largely unknown. The transcription factor ZEB2 is best described for its role in epithelial to mesenchymal transition; however, its role within the immune system is only now being elucidated. We show here that Zeb2 expression is a conserved feature of macrophages. Using Clec4f-cre, Itgax-cre, and Fcgr1-cre mice to target five different macrophage populations, we found that loss of ZEB2 resulted in macrophage disappearance from the tissues, coupled with their subsequent replenishment from bone-marrow precursors in open niches. Mechanistically, we found that ZEB2 functioned to maintain the tissue-specific identities of macrophages. In Kupffer cells, ZEB2 achieved this by regulating expression of the transcription factor LXR alpha, removal of which recapitulated the loss of Kupffer cell identity and disappearance. Thus, ZEB2 expression is required in macrophages to preserve their tissue-specific identities.}},
  author       = {{Scott, Charlotte and T'Jonck, Wouter and Martens, Liesbet and Todorov, Helena and Sichien, Dorine and Soen, Bieke and Bonnardel, Johnny and De Prijck, Sofie and Vandamme, Niels and Cannoodt, Robrecht and Saelens, Wouter and Vanneste, Bavo and Toussaint, Wendy and De Bleser, Pieter and Takahashi, Nozomi and Vandenabeele, Peter and Henri, Sandrine and Pridans, Clare and Hume, David A and Lambrecht, Bart and De Baetselier, Patrick and Milling, Simon WF and Van Ginderachter, Jo A and Malissen, Bernard and Berx, Geert and Beschin, Alain and Saeys, Yvan and Guilliams, Martin}},
  issn         = {{1074-7613}},
  journal      = {{IMMUNITY}},
  keywords     = {{COLONY-STIMULATING FACTOR,DENDRITIC CELLS,RESIDENT MACROPHAGES,IN-VIVO,MOUSE,HOMEOSTASIS,MONOCYTES,MICE,DIFFERENTIATION,EXPRESSION}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{312--325}},
  title        = {{The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages}},
  url          = {{http://dx.doi.org/10.1016/j.immuni.2018.07.004}},
  volume       = {{49}},
  year         = {{2018}},
}
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