@article{8579841,
  abstract     = {{We investigated whether balance control in young TBI patients can be promoted by an S-week balance raining program and whether this is associated with neitroplastic alterations in brain structure. The cerebellum and cerebellar peduncles were selected as regions of interest because of their importance in postural control as well as their vulnerability to brain injury. Young patients with moderate to severe TBI and typically developing (TD) subjects participated in balance training using PC-based portable balancers with storage of training data and real-time visual feedback. An additional control group of TD subjects did not attend balance training. Mean diffusivity and fractional anisotropy were determined with diffusion MRI scans and were acquired before, during (4 weeks) and at completion of training (8 weeks) together with balance assessments on the EquiTest (R) System (NeuroCom) which included the Sensory Organization Test, Rhythmic Weight Shift and Limits of Stability protocols. Following training, TBI patients showed significant improvements on all EquiTest protocols, as well as a significant increase in mean diffusivity in the inferior cerebellar peduncle. Moreover, in both training groups, diffusion metrics in the cerebellum and or cerebellar peduncles at baseline were predictive of the amount of performance increase after training. Finally, amount of training-induced improvement on the Rhythmic Weight Shift test in TBI patients was positively correlated with amount of change in fractional anisotropy in the inferior cerebellar peduncle. This suggests that training-induced plastic changes in balance control are associated with alterations in the cerebellar white matter microstructure in TBI patients.}},
  author       = {{Drijkoningen, David and Caeyenberghs, Karen and Leunissen, Inge and Vander Linden, Catharine and Leemans, Alexander and Sunaert, Stefan and Duysens, Jacques and Swinnen, Stephan P}},
  issn         = {{2213-1582}},
  journal      = {{NEUROIMAGE-CLINICAL}},
  keywords     = {{Brain injury,Cerebellum,Diffusion tensor imaging,Plasticity,Balance control training,MILD HEAD-INJURY,VOXEL-BASED MORPHOMETRY,WII FIT,PARKINSONS-DISEASE,MOTOR-PERFORMANCE,WATER DIFFUSION,BALANCE BOARD,CHILDREN,PLASTICITY,MRI}},
  language     = {{eng}},
  pages        = {{240--251}},
  title        = {{Training-induced improvements in postural control are accompanied by alterations in cerebellar white matter in brain injured patients}},
  url          = {{http://doi.org/10.1016/j.nicl.2014.12.006}},
  volume       = {{7}},
  year         = {{2015}},
}

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