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Eliciting health state utilities from the general public for severe chronic pain

Author
Organization
Abstract
There is an absence of data on public preferences for health states (HSs) associated with severe chronic pain. The aim of this study was to develop accurate HS descriptions for severe chronic pain requiring intrathecal (IT) therapy and to derive utility weights that describe the health-related quality of life (HRQL) impact of chronic pain associated with malignant (MP) and non-malignant (NMP) aetiologies. Eight visual analogue scale pain index (VAS-PI) HSs were defined using ranges 0-40, 41-60, 61-80 and 81-100 applied to both MP and NMP. Additionally, eight HSs representing common adverse events associated with IT therapy were identified. The content and description of the HSs were ascertained by interviews with five United Kingdom clinical experts. In total, 16 HSs were compiled. These HS descriptions and HS questionnaires were administered to 102 members of the public, utilising a time trade off (TTO) approach to estimate utilities for the HSs. Participants generally were well matched to the general public in England and Wales, with some differences in mean age, race and education. A substantial decline in utility was observed with more severe VAS-PI values. The mean TTO utility values also decreased from mild pain to severe pain. Participants were able to differentiate between the side effects. The study shows a clear decrement in utility moving from different severity levels of severe chronic pain.
Keywords
Utility, Intrathecal, Severe chronic pain, Health state, Quality of life, LOW-BACK-PAIN, INTRATHECAL OPIOID DELIVERY, CALCIUM-CHANNEL BLOCKER, NONMALIGNANT PAIN, NEUROPATHIC PAIN, NATURAL-HISTORY, PRIMARY-CARE, CANCER PAIN, N-TYPE, ZICONOTIDE

Citation

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MLA
Eldabe, S et al. “Eliciting Health State Utilities from the General Public for Severe Chronic Pain.” EUROPEAN JOURNAL OF HEALTH ECONOMICS 11.3 (2009): 323–330. Print.
APA
Eldabe, S., Lloyd, A., Verdian, L., Meguro, M., Maclaine, G., & Dewilde, S. (2009). Eliciting health state utilities from the general public for severe chronic pain. EUROPEAN JOURNAL OF HEALTH ECONOMICS, 11(3), 323–330.
Chicago author-date
Eldabe, S, A Lloyd, L Verdian, M Meguro, G Maclaine, and Sarah Dewilde. 2009. “Eliciting Health State Utilities from the General Public for Severe Chronic Pain.” European Journal of Health Economics 11 (3): 323–330.
Chicago author-date (all authors)
Eldabe, S, A Lloyd, L Verdian, M Meguro, G Maclaine, and Sarah Dewilde. 2009. “Eliciting Health State Utilities from the General Public for Severe Chronic Pain.” European Journal of Health Economics 11 (3): 323–330.
Vancouver
1.
Eldabe S, Lloyd A, Verdian L, Meguro M, Maclaine G, Dewilde S. Eliciting health state utilities from the general public for severe chronic pain. EUROPEAN JOURNAL OF HEALTH ECONOMICS. 2009;11(3):323–30.
IEEE
[1]
S. Eldabe, A. Lloyd, L. Verdian, M. Meguro, G. Maclaine, and S. Dewilde, “Eliciting health state utilities from the general public for severe chronic pain,” EUROPEAN JOURNAL OF HEALTH ECONOMICS, vol. 11, no. 3, pp. 323–330, 2009.
@article{8579780,
  abstract     = {There is an absence of data on public preferences for health states (HSs) associated with severe chronic pain. The aim of this study was to develop accurate HS descriptions for severe chronic pain requiring intrathecal (IT) therapy and to derive utility weights that describe the health-related quality of life (HRQL) impact of chronic pain associated with malignant (MP) and non-malignant (NMP) aetiologies. 
Eight visual analogue scale pain index (VAS-PI) HSs were defined using ranges 0-40, 41-60, 61-80 and 81-100 applied to both MP and NMP. Additionally, eight HSs representing common adverse events associated with IT therapy were identified. The content and description of the HSs were ascertained by interviews with five United Kingdom clinical experts. In total, 16 HSs were compiled. These HS descriptions and HS questionnaires were administered to 102 members of the public, utilising a time trade off (TTO) approach to estimate utilities for the HSs. 
Participants generally were well matched to the general public in England and Wales, with some differences in mean age, race and education. A substantial decline in utility was observed with more severe VAS-PI values. The mean TTO utility values also decreased from mild pain to severe pain. Participants were able to differentiate between the side effects. 
The study shows a clear decrement in utility moving from different severity levels of severe chronic pain.},
  author       = {Eldabe, S and Lloyd, A and Verdian, L and Meguro, M and Maclaine, G and Dewilde, Sarah},
  issn         = {1618-7598},
  journal      = {EUROPEAN JOURNAL OF HEALTH ECONOMICS},
  keywords     = {Utility,Intrathecal,Severe chronic pain,Health state,Quality of life,LOW-BACK-PAIN,INTRATHECAL OPIOID DELIVERY,CALCIUM-CHANNEL BLOCKER,NONMALIGNANT PAIN,NEUROPATHIC PAIN,NATURAL-HISTORY,PRIMARY-CARE,CANCER PAIN,N-TYPE,ZICONOTIDE},
  language     = {eng},
  number       = {3},
  pages        = {323--330},
  title        = {Eliciting health state utilities from the general public for severe chronic pain},
  url          = {http://dx.doi.org/10.1007/s10198-009-0178-x},
  volume       = {11},
  year         = {2009},
}

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