A combination of xylooligosaccharides and a polyphenol blend affect microbial composition and activity in the distal colon exerting immunomodulating properties on human cells
- Author
- Pieter Van den Abbeele, Cindy Duysburgh, T Alan Jiang, Marco Rebaza, Iris Pinheiro and Massimo Marzorati (UGent)
- Organization
- Abstract
- A validated in vitro gut model (i.e. SHIME (R)), coupled with co-cultures of epithelial cells and macrophages, was used to investigate the prebiotic potential and immune modulation of long-term administration of a xylooligosaccharides/polyphenols blend. The blend was well fermented along the entire colon leading to increased production of butyrate (+7 mmol/L) in the ascending colon; acetate, propionate and butyrate (approx. +4 mmol/L each) in the transverse colon; propionate (+4.1 mmol/L) in the descending colon. The treatment led to a decrease in ammonium and increased lactate levels in the ascending colon, which correlated with an increase in lactobacilli and bifidobacteria (+2.5 Log/mL). Additionally, the propionate-producing Akkermansia muciniphila increased in the lumen of the proximal colon (up to 7.15 log/mL). Finally, it was observed a protective effect on Caco-2 barrier function in the distal colon and pronounced immune activating properties. The generated data support a possible role in protecting against obesity-related adverse effects.
- Keywords
- XOS, Polyphenols, Prebiotic, SHIME, Akkermansia, Obesity, RED WINE/GRAPE JUICE, CHAIN FATTY-ACIDS, REAL-TIME PCR, AKKERMANSIA-MUCINIPHILA, CHLOROGENIC ACID, BARRIER FUNCTION, NONDIGESTIBLE OLIGOSACCHARIDES, INTESTINAL ENVIRONMENT, XYLO-OLIGOSACCHARIDES, PREBIOTIC PROPERTIES
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8579750
- MLA
- Van den Abbeele, Pieter, et al. “A Combination of Xylooligosaccharides and a Polyphenol Blend Affect Microbial Composition and Activity in the Distal Colon Exerting Immunomodulating Properties on Human Cells.” JOURNAL OF FUNCTIONAL FOODS, vol. 47, 2018, pp. 163–71, doi:10.1016/j.jff.2018.05.053.
- APA
- Van den Abbeele, P., Duysburgh, C., Jiang, T. A., Rebaza, M., Pinheiro, I., & Marzorati, M. (2018). A combination of xylooligosaccharides and a polyphenol blend affect microbial composition and activity in the distal colon exerting immunomodulating properties on human cells. JOURNAL OF FUNCTIONAL FOODS, 47, 163–171. https://doi.org/10.1016/j.jff.2018.05.053
- Chicago author-date
- Van den Abbeele, Pieter, Cindy Duysburgh, T Alan Jiang, Marco Rebaza, Iris Pinheiro, and Massimo Marzorati. 2018. “A Combination of Xylooligosaccharides and a Polyphenol Blend Affect Microbial Composition and Activity in the Distal Colon Exerting Immunomodulating Properties on Human Cells.” JOURNAL OF FUNCTIONAL FOODS 47: 163–71. https://doi.org/10.1016/j.jff.2018.05.053.
- Chicago author-date (all authors)
- Van den Abbeele, Pieter, Cindy Duysburgh, T Alan Jiang, Marco Rebaza, Iris Pinheiro, and Massimo Marzorati. 2018. “A Combination of Xylooligosaccharides and a Polyphenol Blend Affect Microbial Composition and Activity in the Distal Colon Exerting Immunomodulating Properties on Human Cells.” JOURNAL OF FUNCTIONAL FOODS 47: 163–171. doi:10.1016/j.jff.2018.05.053.
- Vancouver
- 1.Van den Abbeele P, Duysburgh C, Jiang TA, Rebaza M, Pinheiro I, Marzorati M. A combination of xylooligosaccharides and a polyphenol blend affect microbial composition and activity in the distal colon exerting immunomodulating properties on human cells. JOURNAL OF FUNCTIONAL FOODS. 2018;47:163–71.
- IEEE
- [1]P. Van den Abbeele, C. Duysburgh, T. A. Jiang, M. Rebaza, I. Pinheiro, and M. Marzorati, “A combination of xylooligosaccharides and a polyphenol blend affect microbial composition and activity in the distal colon exerting immunomodulating properties on human cells,” JOURNAL OF FUNCTIONAL FOODS, vol. 47, pp. 163–171, 2018.
@article{8579750,
abstract = {{A validated in vitro gut model (i.e. SHIME (R)), coupled with co-cultures of epithelial cells and macrophages, was used to investigate the prebiotic potential and immune modulation of long-term administration of a xylooligosaccharides/polyphenols blend. The blend was well fermented along the entire colon leading to increased production of butyrate (+7 mmol/L) in the ascending colon; acetate, propionate and butyrate (approx. +4 mmol/L each) in the transverse colon; propionate (+4.1 mmol/L) in the descending colon. The treatment led to a decrease in ammonium and increased lactate levels in the ascending colon, which correlated with an increase in lactobacilli and bifidobacteria (+2.5 Log/mL). Additionally, the propionate-producing Akkermansia muciniphila increased in the lumen of the proximal colon (up to 7.15 log/mL). Finally, it was observed a protective effect on Caco-2 barrier function in the distal colon and pronounced immune activating properties. The generated data support a possible role in protecting against obesity-related adverse effects.}},
author = {{Van den Abbeele, Pieter and Duysburgh, Cindy and Jiang, T Alan and Rebaza, Marco and Pinheiro, Iris and Marzorati, Massimo}},
issn = {{1756-4646}},
journal = {{JOURNAL OF FUNCTIONAL FOODS}},
keywords = {{XOS,Polyphenols,Prebiotic,SHIME,Akkermansia,Obesity,RED WINE/GRAPE JUICE,CHAIN FATTY-ACIDS,REAL-TIME PCR,AKKERMANSIA-MUCINIPHILA,CHLOROGENIC ACID,BARRIER FUNCTION,NONDIGESTIBLE OLIGOSACCHARIDES,INTESTINAL ENVIRONMENT,XYLO-OLIGOSACCHARIDES,PREBIOTIC PROPERTIES}},
language = {{eng}},
pages = {{163--171}},
title = {{A combination of xylooligosaccharides and a polyphenol blend affect microbial composition and activity in the distal colon exerting immunomodulating properties on human cells}},
url = {{http://doi.org/10.1016/j.jff.2018.05.053}},
volume = {{47}},
year = {{2018}},
}
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