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Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection

Francis Combes (UGent) , Séan Mc Cafferty (UGent) , Evelyne Meyer (UGent) and Niek Sanders (UGent)
(2018) NEOPLASIA. 20(8). p.848-856
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Abstract
Solid tumors frequently coexist with a degree of local chronic inflammation. Recruited myeloid cells can therefore be considered as interesting vehicles for tumor-targeted delivery of therapeutic agents. Using in vivo imaging, the short-term accumulation of systemically injected monocytes, macrophages and myeloid-derived suppressor cells (MDSCs) was compared in mice bearing fat pad mammary carcinomas. Monocytes and macrophages demonstrated almost identical in vivo and ex vivo distribution patterns with maximal tumor-associated accumulation seen 48 hours after injection that remained stable over the 4-day follow-up period. However, a substantial accumulation of both cell types was also seen in the liver, spleen and lungs albeit decreasing over time in all three locations. The MDSCs exhibited a similar distribution pattern as the monocytes and macrophages, but demonstrated a better relative on-target fraction over time. Overall, our findings highlight off-target cell accumulation as a major obstacle in the use of myeloid cells as vehicles for therapeutic tumor-targeted agents and indicate that their short-term on-target accumulation is mainly of nonspecific nature.
Keywords
MAMMARY-CARCINOMA 4T1, ORBITAL VENOUS SINUS, CANCER GENE-THERAPY, BREAST-CANCER, BEARING MICE, MOUSE MODEL, INFILTRATING MACROPHAGES, IMMUNE CELLS, MICROENVIRONMENT, DELIVERY

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Citation

Please use this url to cite or link to this publication:

MLA
Combes, Francis, Séan Mc Cafferty, Evelyne Meyer, et al. “Off-target and Tumor-specific Accumulation of Monocytes, Macrophages and Myeloid-derived Suppressor Cells After Systemic Injection.” NEOPLASIA 20.8 (2018): 848–856. Print.
APA
Combes, Francis, Mc Cafferty, S., Meyer, E., & Sanders, N. (2018). Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection. NEOPLASIA, 20(8), 848–856.
Chicago author-date
Combes, Francis, Séan Mc Cafferty, Evelyne Meyer, and Niek Sanders. 2018. “Off-target and Tumor-specific Accumulation of Monocytes, Macrophages and Myeloid-derived Suppressor Cells After Systemic Injection.” Neoplasia 20 (8): 848–856.
Chicago author-date (all authors)
Combes, Francis, Séan Mc Cafferty, Evelyne Meyer, and Niek Sanders. 2018. “Off-target and Tumor-specific Accumulation of Monocytes, Macrophages and Myeloid-derived Suppressor Cells After Systemic Injection.” Neoplasia 20 (8): 848–856.
Vancouver
1.
Combes F, Mc Cafferty S, Meyer E, Sanders N. Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection. NEOPLASIA. 2018;20(8):848–56.
IEEE
[1]
F. Combes, S. Mc Cafferty, E. Meyer, and N. Sanders, “Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection,” NEOPLASIA, vol. 20, no. 8, pp. 848–856, 2018.
@article{8578976,
  abstract     = {Solid tumors frequently coexist with a degree of local chronic inflammation. Recruited myeloid cells can therefore be considered as interesting vehicles for tumor-targeted delivery of therapeutic agents. Using in vivo imaging, the short-term accumulation of systemically injected monocytes, macrophages and myeloid-derived suppressor cells (MDSCs) was compared in mice bearing fat pad mammary carcinomas. Monocytes and macrophages demonstrated almost identical in vivo and ex vivo distribution patterns with maximal tumor-associated accumulation seen 48 hours after injection that remained stable over the 4-day follow-up period. However, a substantial accumulation of both cell types was also seen in the liver, spleen and lungs albeit decreasing over time in all three locations. The MDSCs exhibited a similar distribution pattern as the monocytes and macrophages, but demonstrated a better relative on-target fraction over time. Overall, our findings highlight off-target cell accumulation as a major obstacle in the use of myeloid cells as vehicles for therapeutic tumor-targeted agents and indicate that their short-term on-target accumulation is mainly of nonspecific nature.},
  author       = {Combes, Francis and Mc Cafferty, Séan and Meyer, Evelyne and Sanders, Niek},
  issn         = {1476-5586},
  journal      = {NEOPLASIA},
  keywords     = {MAMMARY-CARCINOMA 4T1,ORBITAL VENOUS SINUS,CANCER GENE-THERAPY,BREAST-CANCER,BEARING MICE,MOUSE MODEL,INFILTRATING MACROPHAGES,IMMUNE CELLS,MICROENVIRONMENT,DELIVERY},
  language     = {eng},
  number       = {8},
  pages        = {848--856},
  title        = {Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection},
  url          = {http://dx.doi.org/10.1016/j.neo.2018.06.005},
  volume       = {20},
  year         = {2018},
}

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