@inproceedings{8578930,
  abstract     = {{Aquatic and terrestrial ecosystems are exposed to radionuclides through planned discharges or accidental releases linked with the nuclear industry activities. Over the past decade, ecosystems protection against ionizing radiation has become a growing public, regulatory and scientific concern. Nowadays, ecological risk assessment for ionizing radiation is based on a majority of radiotoxocity tests under acute doses and short exposure time, far from realistic environmental conditions in which natural biota are actually exposed. Recently, studies in daphnids at chronic low doses have been conducted over several generations in order to understand the long-term effects of low doses of gamma radiation and explore the contribution of underlying molecular mechanisms, such as DNA alterations. In this context, radio-induced epigenetic modifications have never been investigated in invertebrate species although ionizing radiation were shown to induce changes in DNA methylation patterns and gene expression. This suggests that epigenetic modifications might be inherited across generations. In this context, the present study examines the potential transmission of epigenetic alterations caused by a life-long gamma irradiation to their non-irradiated progeny up to the third generation, using the microcrustacean Daphnia magna as a model organism. The aim of our study is to test whether effects on survival, growth and reproduction observed in daphnids exposed to gamma radiation (in generation referred as F0) might persist in their non-exposed offspring generations (referred as F1, F2 and F3) and whether it might be linked to modifications of DNA methylation patterns inherited across generations. Results showed significant effects of gamma radiation on fecundity only for the highest dose rate and no effect at organism level seemed to last across non-exposed generations. However, effects on DNA methylation at low dose rate and across generations are not excluded. Our study will give a better insight in the effect of ionizing radiation on epigenetic processes, their heritability across generation and their link to organism level effects.}},
  author       = {{Trijau, Marie and Asselman, Jana and Armant, Olivier and Adam-Guillermin, Christelle and De Schamphelaere, Karel and Alonzo, Frederic}},
  booktitle    = {{SETAC Europe, 27th Annual meeting, Abstracts}},
  language     = {{eng}},
  location     = {{Brussels, Belgium}},
  title        = {{Transgenerational effects and epigenetic inheritance following a chronic external gamma irradiation in Daphnia magna}},
  year         = {{2017}},
}