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L1CAM expression in endometrial carcinomas : an ENITEC collaboration study

(2016) BRITISH JOURNAL OF CANCER. 115(6). p.716-724
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Abstract
Background: Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas. Methods: The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when >10% of the tumour cells expressed L1CAM. The association between L1CAM expression and several clincopathological characteristics and disease outcome was calculated. Results: In all, L1CAM was expressed in 10% of the 935 stage I EECs, 18% of the 160 advanced stage EECs, and 75% of the 104 NEECs. The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the EECs, but not in the NEECs. Conclusions: The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs. It is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. The value of L1CAM expression in the preoperative selection of high-risk endometrial carcinomas should be studied.
Keywords
endometrial cancer, endometrioid, non-endometrioid, L1CAM, immunohistochemistry, CELL-ADHESION MOLECULE, NF-KAPPA-B, UP-REGULATION, PROGNOSTIC-SIGNIFICANCE, CANCER PROGRESSION, POOR-PROGNOSIS, OVARIAN-CANCER, BREAST-CANCER, L1 EXPRESSION, SOLUBLE FORM

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MLA
van der Putten, Louis JM, Nicole CM Visser, Koen Van de Vijver, et al. “L1CAM Expression in Endometrial Carcinomas : an ENITEC Collaboration Study.” BRITISH JOURNAL OF CANCER 115.6 (2016): 716–724. Print.
APA
van der Putten, L. J., Visser, N. C., Van de Vijver, K., Santacana, M., Bronsert, P., Bulten, J., Hirschfeld, M., et al. (2016). L1CAM expression in endometrial carcinomas : an ENITEC collaboration study. BRITISH JOURNAL OF CANCER, 115(6), 716–724.
Chicago author-date
van der Putten, Louis JM, Nicole CM Visser, Koen Van de Vijver, Maria Santacana, Peter Bronsert, Johan Bulten, Marc Hirschfeld, et al. 2016. “L1CAM Expression in Endometrial Carcinomas : an ENITEC Collaboration Study.” British Journal of Cancer 115 (6): 716–724.
Chicago author-date (all authors)
van der Putten, Louis JM, Nicole CM Visser, Koen Van de Vijver, Maria Santacana, Peter Bronsert, Johan Bulten, Marc Hirschfeld, Eva Colas, Antonio Gil-Moreno, Angel Garcia, Gemma Mancebo, Fransesc Alameda, Jone Trovik, Reidun K Kopperud, Jutta Huvila, Stefanie Schrauwen, Martin Koskas, Francine Walker, Vit Weinberger, Lubos Minar, Eva Jandakova, Marc PLM Snijders, Saskia van den Berg-van Erp, Xavier Matias-Guiu, Helga B Salvesen, Frederic Amant, Leon FAG Massuger, and Johanna MA Pijnenborg. 2016. “L1CAM Expression in Endometrial Carcinomas : an ENITEC Collaboration Study.” British Journal of Cancer 115 (6): 716–724.
Vancouver
1.
van der Putten LJ, Visser NC, Van de Vijver K, Santacana M, Bronsert P, Bulten J, et al. L1CAM expression in endometrial carcinomas : an ENITEC collaboration study. BRITISH JOURNAL OF CANCER. 2016;115(6):716–24.
IEEE
[1]
L. J. van der Putten et al., “L1CAM expression in endometrial carcinomas : an ENITEC collaboration study,” BRITISH JOURNAL OF CANCER, vol. 115, no. 6, pp. 716–724, 2016.
@article{8578550,
  abstract     = {Background: Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas. 
Methods: The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when >10% of the tumour cells expressed L1CAM. The association between L1CAM expression and several clincopathological characteristics and disease outcome was calculated. 
Results: In all, L1CAM was expressed in 10% of the 935 stage I EECs, 18% of the 160 advanced stage EECs, and 75% of the 104 NEECs. The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the EECs, but not in the NEECs. 
Conclusions: The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs. It is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. The value of L1CAM expression in the preoperative selection of high-risk endometrial carcinomas should be studied.},
  author       = {van der Putten, Louis JM and Visser, Nicole CM and Van de Vijver, Koen and Santacana, Maria and Bronsert, Peter and Bulten, Johan and Hirschfeld, Marc and Colas, Eva and Gil-Moreno, Antonio and Garcia, Angel and Mancebo, Gemma and Alameda, Fransesc and Trovik, Jone and Kopperud, Reidun K and Huvila, Jutta and Schrauwen, Stefanie and Koskas, Martin and Walker, Francine and Weinberger, Vit and Minar, Lubos and Jandakova, Eva and Snijders, Marc PLM and van den Berg-van Erp, Saskia and Matias-Guiu, Xavier and Salvesen, Helga B and Amant, Frederic and Massuger, Leon FAG and Pijnenborg, Johanna MA},
  issn         = {0007-0920},
  journal      = {BRITISH JOURNAL OF CANCER},
  keywords     = {endometrial cancer,endometrioid,non-endometrioid,L1CAM,immunohistochemistry,CELL-ADHESION MOLECULE,NF-KAPPA-B,UP-REGULATION,PROGNOSTIC-SIGNIFICANCE,CANCER PROGRESSION,POOR-PROGNOSIS,OVARIAN-CANCER,BREAST-CANCER,L1 EXPRESSION,SOLUBLE FORM},
  language     = {eng},
  number       = {6},
  pages        = {716--724},
  title        = {L1CAM expression in endometrial carcinomas : an ENITEC collaboration study},
  url          = {http://dx.doi.org/10.1038/bjc.2016.235},
  volume       = {115},
  year         = {2016},
}

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