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Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease : behavioral and neural studies

Ahmed A. Moustafa, Srinivasa Chakravarthy, Joseph R. Phillips, Jacob J. Crouse, Ankur Gupta, Michael J. Frank, Julie Hall (UGent) and Marjan Jahanshahi
(2016) REVIEWS IN THE NEUROSCIENCES. 27(5). p.535-548
Author
Organization
Abstract
Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (tremor, bradykinesia/akinesia, and rigidity), PD patients also show other motor deficits, including gait disturbance, speech deficits, and impaired handwriting. However, along with these key motor symptoms, PD patients also experience cognitive deficits in attention, executive function, working memory, and learning. Recent evidence suggests that these motor and cognitive deficits of PD are not completely dissociable, as aspects of cognitive dysfunction can impact motor performance in PD. In this article, we provide a review of behavioral and neural studies on the associations between motor symptoms and cognitive deficits in PD, specifically akinesia/bradykinesia, tremor, gait, handwriting, precision grip, and speech production. This review paves the way for providing a framework for understanding how treatment of cognitive dysfunction, for example cognitive rehabilitation programs, may in turn influence the motor symptoms of PD.
Keywords
akinesia, bradykinesia, cognitive dysfunction, cognitive training, freezing of gait, grip force, Parkinson's disease, postural instability, tremor, IMPULSE CONTROL DISORDERS, DEEP BRAIN-STIMULATION, GRAY-MATTER ATROPHY, BASAL GANGLIA, WORKING-MEMORY, POSTURAL INSTABILITY, COMPUTATIONAL MODEL, SUBTHALAMIC NUCLEUS, PREFRONTAL CORTEX, RESTING TREMOR

Citation

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MLA
Moustafa, Ahmed A., et al. “Interrelations between Cognitive Dysfunction and Motor Symptoms of Parkinson’s Disease : Behavioral and Neural Studies.” REVIEWS IN THE NEUROSCIENCES, vol. 27, no. 5, 2016, pp. 535–48, doi:10.1515/revneuro-2015-0070.
APA
Moustafa, A. A., Chakravarthy, S., Phillips, J. R., Crouse, J. J., Gupta, A., Frank, M. J., … Jahanshahi, M. (2016). Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease : behavioral and neural studies. REVIEWS IN THE NEUROSCIENCES, 27(5), 535–548. https://doi.org/10.1515/revneuro-2015-0070
Chicago author-date
Moustafa, Ahmed A., Srinivasa Chakravarthy, Joseph R. Phillips, Jacob J. Crouse, Ankur Gupta, Michael J. Frank, Julie Hall, and Marjan Jahanshahi. 2016. “Interrelations between Cognitive Dysfunction and Motor Symptoms of Parkinson’s Disease : Behavioral and Neural Studies.” REVIEWS IN THE NEUROSCIENCES 27 (5): 535–48. https://doi.org/10.1515/revneuro-2015-0070.
Chicago author-date (all authors)
Moustafa, Ahmed A., Srinivasa Chakravarthy, Joseph R. Phillips, Jacob J. Crouse, Ankur Gupta, Michael J. Frank, Julie Hall, and Marjan Jahanshahi. 2016. “Interrelations between Cognitive Dysfunction and Motor Symptoms of Parkinson’s Disease : Behavioral and Neural Studies.” REVIEWS IN THE NEUROSCIENCES 27 (5): 535–548. doi:10.1515/revneuro-2015-0070.
Vancouver
1.
Moustafa AA, Chakravarthy S, Phillips JR, Crouse JJ, Gupta A, Frank MJ, et al. Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease : behavioral and neural studies. REVIEWS IN THE NEUROSCIENCES. 2016;27(5):535–48.
IEEE
[1]
A. A. Moustafa et al., “Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease : behavioral and neural studies,” REVIEWS IN THE NEUROSCIENCES, vol. 27, no. 5, pp. 535–548, 2016.
@article{8578274,
  abstract     = {{Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (tremor, bradykinesia/akinesia, and rigidity), PD patients also show other motor deficits, including gait disturbance, speech deficits, and impaired handwriting. However, along with these key motor symptoms, PD patients also experience cognitive deficits in attention, executive function, working memory, and learning. Recent evidence suggests that these motor and cognitive deficits of PD are not completely dissociable, as aspects of cognitive dysfunction can impact motor performance in PD. In this article, we provide a review of behavioral and neural studies on the associations between motor symptoms and cognitive deficits in PD, specifically akinesia/bradykinesia, tremor, gait, handwriting, precision grip, and speech production. This review paves the way for providing a framework for understanding how treatment of cognitive dysfunction, for example cognitive rehabilitation programs, may in turn influence the motor symptoms of PD.}},
  author       = {{Moustafa, Ahmed A. and Chakravarthy, Srinivasa and Phillips, Joseph R. and Crouse, Jacob J. and Gupta, Ankur and Frank, Michael J. and Hall, Julie and Jahanshahi, Marjan}},
  issn         = {{0334-1763}},
  journal      = {{REVIEWS IN THE NEUROSCIENCES}},
  keywords     = {{akinesia,bradykinesia,cognitive dysfunction,cognitive training,freezing of gait,grip force,Parkinson's disease,postural instability,tremor,IMPULSE CONTROL DISORDERS,DEEP BRAIN-STIMULATION,GRAY-MATTER ATROPHY,BASAL GANGLIA,WORKING-MEMORY,POSTURAL INSTABILITY,COMPUTATIONAL MODEL,SUBTHALAMIC NUCLEUS,PREFRONTAL CORTEX,RESTING TREMOR}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{535--548}},
  title        = {{Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease : behavioral and neural studies}},
  url          = {{http://doi.org/10.1515/revneuro-2015-0070}},
  volume       = {{27}},
  year         = {{2016}},
}
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