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Probing plant receptor kinase functions with labeled ligands

Isha Sharma (UGent) and Eugenia Russinova (UGent)
(2018) PLANT AND CELL PHYSIOLOGY. 59(8). p.1520-1527
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Organization
Abstract
Plant cells rely on numerous membrane-localized receptor kinases for communication with each other as well as with the environment to ensure coordinated growth, development and survival. Additionally, several families of small secreted peptides have been identified in plants that possibly regulate various developmental processes through activation of specific membrane receptor kinases. In research efforts to elucidate the underlying signaling processes in plants, it has become obvious that knowledge of both the extracellular ligand and its corresponding receptor(s) is a prerequisite to understand cell communication. Of more than 1,000 orphan peptides in plants, only a few have been functionally characterized and paired with their respective receptors. Here, we discuss recent advances made in the field of receptor-ligand pairing and visualization in plant cells by means of chemically labeled ligands. We summarize and compare various chemical strategies from the mammalian field that can be employed to extend our understanding of the plant receptor kinase functions in plants.
Keywords
CELL-SURFACE RECEPTORS, LIVING CELLS, IN-VIVO, PATTERN-RECOGNITION, SIGNALING PEPTIDES, STRUCTURAL INSIGHT, CRYSTAL-STRUCTURE, ARABIDOPSIS, BINDING, IDENTIFICATION, Chemical cross-linking, Ligands, Receptor kinases, Signaling peptides, Synthetic peptides

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Citation

Please use this url to cite or link to this publication:

MLA
Sharma, Isha, and Eugenia Russinova. “Probing Plant Receptor Kinase Functions with Labeled Ligands.” PLANT AND CELL PHYSIOLOGY 59.8 (2018): 1520–1527. Print.
APA
Sharma, I., & Russinova, E. (2018). Probing plant receptor kinase functions with labeled ligands. PLANT AND CELL PHYSIOLOGY, 59(8), 1520–1527.
Chicago author-date
Sharma, Isha, and Eugenia Russinova. 2018. “Probing Plant Receptor Kinase Functions with Labeled Ligands.” Plant and Cell Physiology 59 (8): 1520–1527.
Chicago author-date (all authors)
Sharma, Isha, and Eugenia Russinova. 2018. “Probing Plant Receptor Kinase Functions with Labeled Ligands.” Plant and Cell Physiology 59 (8): 1520–1527.
Vancouver
1.
Sharma I, Russinova E. Probing plant receptor kinase functions with labeled ligands. PLANT AND CELL PHYSIOLOGY. 2018;59(8):1520–7.
IEEE
[1]
I. Sharma and E. Russinova, “Probing plant receptor kinase functions with labeled ligands,” PLANT AND CELL PHYSIOLOGY, vol. 59, no. 8, pp. 1520–1527, 2018.
@article{8577885,
  abstract     = {Plant cells rely on numerous membrane-localized receptor kinases for communication with each other as well as with the environment to ensure coordinated growth, development and survival. Additionally, several families of small secreted peptides have been identified in plants that possibly regulate various developmental processes through activation of specific membrane receptor kinases. In research efforts to elucidate the underlying signaling processes in plants, it has become obvious that knowledge of both the extracellular ligand and its corresponding receptor(s) is a prerequisite to understand cell communication. Of more than 1,000 orphan peptides in plants, only a few have been functionally characterized and paired with their respective receptors. Here, we discuss recent advances made in the field of receptor-ligand pairing and visualization in plant cells by means of chemically labeled ligands. We summarize and compare various chemical strategies from the mammalian field that can be employed to extend our understanding of the plant receptor kinase functions in plants.},
  author       = {Sharma, Isha and Russinova, Eugenia},
  issn         = {0032-0781},
  journal      = {PLANT AND CELL PHYSIOLOGY},
  keywords     = {CELL-SURFACE RECEPTORS,LIVING CELLS,IN-VIVO,PATTERN-RECOGNITION,SIGNALING PEPTIDES,STRUCTURAL INSIGHT,CRYSTAL-STRUCTURE,ARABIDOPSIS,BINDING,IDENTIFICATION,Chemical cross-linking,Ligands,Receptor kinases,Signaling peptides,Synthetic peptides},
  language     = {eng},
  number       = {8},
  pages        = {1520--1527},
  title        = {Probing plant receptor kinase functions with labeled ligands},
  url          = {http://dx.doi.org/10.1093/pcp/pcy092},
  volume       = {59},
  year         = {2018},
}

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