Advanced search
1 file | 263.81 KB Add to list

On doubly robust estimation of the hazard difference

(2019) BIOMETRICS. 75(1). p.100-109
Author
Organization
Abstract
The estimation of conditional treatment effects in an observational study with a survival outcome typically involves fitting a hazards regression model adjusted for a high-dimensional covariate. Standard estimation of the treatment effect is then not entirely satisfactory, as the misspecification of the effect of this covariate may induce a large bias. Such misspecification is a particular concern when inferring the hazard difference, because it is difficult to postulate additive hazards models that guarantee non-negative hazards over the entire observed covariate range. We therefore consider a novel class of semiparametric additive hazards models which leave the effects of covariates unspecified. The efficient score under this model is derived. We then propose two different estimation approaches for the hazard difference (and hence also the relative chance of survival), both of which yield estimators that are doubly robust. The approaches are illustrated using simulation studies and data on right heart catheterization and mortality from the SUPPORT study.
Keywords
Additive hazards model, Causal inference, Doubly robust estimation, Lifetime and survival analysis, Semiparametric inference, MODELS, NONCOMPLIANCE, INFERENCE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 263.81 KB

Citation

Please use this url to cite or link to this publication:

MLA
Dukes, Oliver, et al. “On Doubly Robust Estimation of the Hazard Difference.” BIOMETRICS, vol. 75, no. 1, 2019, pp. 100–09.
APA
Dukes, O., Martinussen, T., Tchetgen Tchetgen, E. J., & Vansteelandt, S. (2019). On doubly robust estimation of the hazard difference. BIOMETRICS, 75(1), 100–109.
Chicago author-date
Dukes, Oliver, Torben Martinussen, Eric J Tchetgen Tchetgen, and Stijn Vansteelandt. 2019. “On Doubly Robust Estimation of the Hazard Difference.” BIOMETRICS 75 (1): 100–109.
Chicago author-date (all authors)
Dukes, Oliver, Torben Martinussen, Eric J Tchetgen Tchetgen, and Stijn Vansteelandt. 2019. “On Doubly Robust Estimation of the Hazard Difference.” BIOMETRICS 75 (1): 100–109.
Vancouver
1.
Dukes O, Martinussen T, Tchetgen Tchetgen EJ, Vansteelandt S. On doubly robust estimation of the hazard difference. BIOMETRICS. 2019;75(1):100–9.
IEEE
[1]
O. Dukes, T. Martinussen, E. J. Tchetgen Tchetgen, and S. Vansteelandt, “On doubly robust estimation of the hazard difference,” BIOMETRICS, vol. 75, no. 1, pp. 100–109, 2019.
@article{8577821,
  abstract     = {The estimation of conditional treatment effects in an observational study with a survival outcome typically involves fitting a hazards regression model adjusted for a high-dimensional covariate. Standard estimation of the treatment effect is then not entirely satisfactory, as the misspecification of the effect of this covariate may induce a large bias. Such misspecification is a particular concern when inferring the hazard difference, because it is difficult to postulate additive hazards models that guarantee non-negative hazards over the entire observed covariate range. We therefore consider a novel class of semiparametric additive hazards models which leave the effects of covariates unspecified. The efficient score under this model is derived. We then propose two different estimation approaches for the hazard difference (and hence also the relative chance of survival), both of which yield estimators that are doubly robust. The approaches are illustrated using simulation studies and data on right heart catheterization and mortality from the SUPPORT study.},
  author       = {Dukes, Oliver and Martinussen, Torben and Tchetgen Tchetgen, Eric J and Vansteelandt, Stijn},
  issn         = {0006-341X},
  journal      = {BIOMETRICS},
  keywords     = {Additive hazards model,Causal inference,Doubly robust estimation,Lifetime and survival analysis,Semiparametric inference,MODELS,NONCOMPLIANCE,INFERENCE},
  language     = {eng},
  number       = {1},
  pages        = {100--109},
  title        = {On doubly robust estimation of the hazard difference},
  url          = {http://dx.doi.org/10.1111/biom.12943},
  volume       = {75},
  year         = {2019},
}

Altmetric
View in Altmetric
Web of Science
Times cited: