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Assessing tumor-infiltrating lymphocytes in solid tumors : a practical review for pathologists and proposal for a standardized method from the International Immunooncology Biomarkers Working Group, part 1 : assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research

(2017) ADVANCES IN ANATOMIC PATHOLOGY. 24(5). p.235-251
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Abstract
Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.
Keywords
lymphocytes, tumor-infiltrating, biomarkers, cancer, immunotherapy, pathology, CELL LUNG-CANCER, REGULATORY T-CELLS, TERTIARY LYMPHOID STRUCTURES, NODE MELANOMA METASTASES, COLORECTAL-CANCER, PD-1 BLOCKADE, PROGNOSTIC-SIGNIFICANCE, MEDULLARY CARCINOMA, ESTROGEN-RECEPTOR, SPATIAL HETEROGENEITY

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MLA
Hendry, Shona, Roberto Salgado, Thomas Gevaert, et al. “Assessing Tumor-infiltrating Lymphocytes in Solid Tumors : a Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group, Part 1 : Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research.” ADVANCES IN ANATOMIC PATHOLOGY 24.5 (2017): 235–251. Print.
APA
Hendry, S., Salgado, R., Gevaert, T., Russell, P. A., John, T., Thapa, B., Christie, M., et al. (2017). Assessing tumor-infiltrating lymphocytes in solid tumors : a practical review for pathologists and proposal for a standardized method from the International Immunooncology Biomarkers Working Group, part 1 : assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research. ADVANCES IN ANATOMIC PATHOLOGY, 24(5), 235–251.
Chicago author-date
Hendry, Shona, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, Bibhusal Thapa, Michael Christie, et al. 2017. “Assessing Tumor-infiltrating Lymphocytes in Solid Tumors : a Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group, Part 1 : Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research.” Advances in Anatomic Pathology 24 (5): 235–251.
Chicago author-date (all authors)
Hendry, Shona, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen Van de Vijver, M.V Estrada, Paula I Gonzalez-Ericsson, Melinda Sanders, Benjamin Solomon, Cinzia Solinas, Gert GGM Van den Eynden, Yves Allory, Matthias Preusser, Johannes Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra Demaria, Fraser Symmans, Paolo Nuciforo, Laura Comerma, EA Thompson, Sunil Lakhani, Seong-Rim Kim, Stuart Schnitt, Cecile Colpaert, Christos Sotiriou, Stefan J Scherer, Michail Ignatiadis, Sunil Badve, Robert H Pierce, Giuseppe Viale, Nicolas Sirtaine, Frederique Penault-Llorca, Tomohagu Sugie, Susan Fineberg, Soonmyung Paik, Ashok Srinivasan, Andrea Richardson, Yihong Wang, Ewa Chmielik, Jane Brock, Douglas B Johnson, Justin Balko, Stephan Wienert, Veerle Bossuyt, Stefan Michiels, Nils Ternes, Nicole Burchardi, Stephen J Luen, Peter Savas, Frederick Klauschen, Peter H Watson, Brad H Nelson, Carmen Criscitiello, Sandra O’Toole, Denis Larsimont, Roland de Wind, Giuseppe Curigliano, Fabrice André, Magali Lacroix-Triki, Mark van de Vijver, Federico Rojo, Giuseppe Floris, Shahinaz Bedri, Joseph Sparano, David Rimm, Torsten Nielsen, Zuzana Kos, Stephen Hewitt, Baljit Singh, Gelareh Farshid, Sibylle Loibl, Kimberly H Allison, Nadine Tung, Sylvia Adams, Karen Willard-Gallo, Hugo M Horlings, Leena Gandhi, Andre Moreira, Fred Hirsch, Maria V Dieci, Maria Urbanowicz, Iva Brcic, Konstanty Korski, Fabien Gaire, Hartmut Koeppen, Amy Lo, Jennifer Giltnane, Marlon C Rebelatto, Keith E Steele, Jiping Zha, Kenneth Emancipator, Jonathan W Juco, Carsten Denkert, Jorge Reis-Filho, Sherene Loi, and Stephen B Fox. 2017. “Assessing Tumor-infiltrating Lymphocytes in Solid Tumors : a Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group, Part 1 : Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research.” Advances in Anatomic Pathology 24 (5): 235–251.
Vancouver
1.
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, et al. Assessing tumor-infiltrating lymphocytes in solid tumors : a practical review for pathologists and proposal for a standardized method from the International Immunooncology Biomarkers Working Group, part 1 : assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research. ADVANCES IN ANATOMIC PATHOLOGY. 2017;24(5):235–51.
IEEE
[1]
S. Hendry et al., “Assessing tumor-infiltrating lymphocytes in solid tumors : a practical review for pathologists and proposal for a standardized method from the International Immunooncology Biomarkers Working Group, part 1 : assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research,” ADVANCES IN ANATOMIC PATHOLOGY, vol. 24, no. 5, pp. 235–251, 2017.
@article{8577567,
  abstract     = {Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.},
  author       = {Hendry, Shona and Salgado, Roberto and Gevaert, Thomas and Russell, Prudence A and John, Tom and Thapa, Bibhusal and Christie, Michael and Van de Vijver, Koen and Estrada, M.V and Gonzalez-Ericsson, Paula I and Sanders, Melinda and Solomon, Benjamin and Solinas, Cinzia and Van den Eynden, Gert GGM and Allory, Yves and Preusser, Matthias and Hainfellner, Johannes and Pruneri, Giancarlo and Vingiani, Andrea and Demaria, Sandra and Symmans, Fraser and Nuciforo, Paolo and Comerma, Laura and Thompson, EA and Lakhani, Sunil and Kim, Seong-Rim and Schnitt, Stuart and Colpaert, Cecile and Sotiriou, Christos and Scherer, Stefan J and Ignatiadis, Michail and Badve, Sunil and Pierce, Robert H and Viale, Giuseppe and Sirtaine, Nicolas and Penault-Llorca, Frederique and Sugie, Tomohagu and Fineberg, Susan and Paik, Soonmyung and Srinivasan, Ashok and Richardson, Andrea and Wang, Yihong and Chmielik, Ewa and Brock, Jane and Johnson, Douglas B and Balko, Justin and Wienert, Stephan and Bossuyt, Veerle and Michiels, Stefan and Ternes, Nils and Burchardi, Nicole and Luen, Stephen J and Savas, Peter and Klauschen, Frederick and Watson, Peter H and Nelson, Brad H and Criscitiello, Carmen and O’Toole, Sandra and Larsimont, Denis and de Wind, Roland and Curigliano, Giuseppe and André, Fabrice and Lacroix-Triki, Magali and van de Vijver, Mark and Rojo, Federico and Floris, Giuseppe and Bedri, Shahinaz and Sparano, Joseph and Rimm, David and Nielsen, Torsten and Kos, Zuzana and Hewitt, Stephen and Singh, Baljit and Farshid, Gelareh and Loibl, Sibylle and Allison, Kimberly H and Tung, Nadine and Adams, Sylvia and Willard-Gallo, Karen and Horlings, Hugo M and Gandhi, Leena and Moreira, Andre and Hirsch, Fred and Dieci, Maria V and Urbanowicz, Maria and Brcic, Iva and Korski, Konstanty and Gaire, Fabien and Koeppen, Hartmut and Lo, Amy and Giltnane, Jennifer and Rebelatto, Marlon C and Steele, Keith E and Zha, Jiping and Emancipator, Kenneth and Juco, Jonathan W and Denkert, Carsten and Reis-Filho, Jorge and Loi, Sherene and Fox, Stephen B},
  issn         = {1072-4109},
  journal      = {ADVANCES IN ANATOMIC PATHOLOGY},
  keywords     = {lymphocytes,tumor-infiltrating,biomarkers,cancer,immunotherapy,pathology,CELL LUNG-CANCER,REGULATORY T-CELLS,TERTIARY LYMPHOID STRUCTURES,NODE MELANOMA METASTASES,COLORECTAL-CANCER,PD-1 BLOCKADE,PROGNOSTIC-SIGNIFICANCE,MEDULLARY CARCINOMA,ESTROGEN-RECEPTOR,SPATIAL HETEROGENEITY},
  language     = {eng},
  number       = {5},
  pages        = {235--251},
  title        = {Assessing tumor-infiltrating lymphocytes in solid tumors : a practical review for pathologists and proposal for a standardized method from the International Immunooncology Biomarkers Working Group, part 1 : assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research},
  url          = {http://dx.doi.org/10.1097/pap.0000000000000162},
  volume       = {24},
  year         = {2017},
}

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