Molecular actions of PPARα in lipid metabolism and inflammation
- Author
- Nadia Bougarne, Basiel Weyers, Sofie Desmet (UGent) , Julie Deckers (UGent) , David W Ray, Bart Staels and Karolien De Bosscher (UGent)
- Organization
- Abstract
- Peroxisome proliferator-activated receptor a (PPAR alpha) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPAR alpha also exhibits marked anti-inflammatory capacities. The first-generation PPAR alpha agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPAR alpha works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.
- Keywords
- PROLIFERATOR-ACTIVATED-RECEPTOR, FATTY-ACID OXIDATION, RETINOID-X-RECEPTOR, TYPE-2 DIABETES-MELLITUS, APOLIPOPROTEIN-C-III, NF-KAPPA-B, CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE, PALMITOYLTRANSFERASE-I GENE, LIPOPROTEIN-LIPASE ACTIVITY, CORONARY-ARTERY-DISEASE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8577093
- MLA
- Bougarne, Nadia, et al. “Molecular Actions of PPARα in Lipid Metabolism and Inflammation.” ENDOCRINE REVIEWS, vol. 39, no. 5, 2018, pp. 760–802, doi:10.1210/er.2018-00064.
- APA
- Bougarne, N., Weyers, B., Desmet, S., Deckers, J., Ray, D. W., Staels, B., & De Bosscher, K. (2018). Molecular actions of PPARα in lipid metabolism and inflammation. ENDOCRINE REVIEWS, 39(5), 760–802. https://doi.org/10.1210/er.2018-00064
- Chicago author-date
- Bougarne, Nadia, Basiel Weyers, Sofie Desmet, Julie Deckers, David W Ray, Bart Staels, and Karolien De Bosscher. 2018. “Molecular Actions of PPARα in Lipid Metabolism and Inflammation.” ENDOCRINE REVIEWS 39 (5): 760–802. https://doi.org/10.1210/er.2018-00064.
- Chicago author-date (all authors)
- Bougarne, Nadia, Basiel Weyers, Sofie Desmet, Julie Deckers, David W Ray, Bart Staels, and Karolien De Bosscher. 2018. “Molecular Actions of PPARα in Lipid Metabolism and Inflammation.” ENDOCRINE REVIEWS 39 (5): 760–802. doi:10.1210/er.2018-00064.
- Vancouver
- 1.Bougarne N, Weyers B, Desmet S, Deckers J, Ray DW, Staels B, et al. Molecular actions of PPARα in lipid metabolism and inflammation. ENDOCRINE REVIEWS. 2018;39(5):760–802.
- IEEE
- [1]N. Bougarne et al., “Molecular actions of PPARα in lipid metabolism and inflammation,” ENDOCRINE REVIEWS, vol. 39, no. 5, pp. 760–802, 2018.
@article{8577093,
abstract = {{Peroxisome proliferator-activated receptor a (PPAR alpha) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPAR alpha also exhibits marked anti-inflammatory capacities. The first-generation PPAR alpha agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPAR alpha works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.}},
author = {{Bougarne, Nadia and Weyers, Basiel and Desmet, Sofie and Deckers, Julie and Ray, David W and Staels, Bart and De Bosscher, Karolien}},
issn = {{0163-769X}},
journal = {{ENDOCRINE REVIEWS}},
keywords = {{PROLIFERATOR-ACTIVATED-RECEPTOR,FATTY-ACID OXIDATION,RETINOID-X-RECEPTOR,TYPE-2 DIABETES-MELLITUS,APOLIPOPROTEIN-C-III,NF-KAPPA-B,CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE,PALMITOYLTRANSFERASE-I GENE,LIPOPROTEIN-LIPASE ACTIVITY,CORONARY-ARTERY-DISEASE}},
language = {{eng}},
number = {{5}},
pages = {{760--802}},
title = {{Molecular actions of PPARα in lipid metabolism and inflammation}},
url = {{http://doi.org/10.1210/er.2018-00064}},
volume = {{39}},
year = {{2018}},
}
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