Advanced search
1 file | 3.60 MB Add to list

Molecular actions of PPARα in lipid metabolism and inflammation

(2018) ENDOCRINE REVIEWS. 39(5). p.760-802
Author
Organization
Abstract
Peroxisome proliferator-activated receptor a (PPAR alpha) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPAR alpha also exhibits marked anti-inflammatory capacities. The first-generation PPAR alpha agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPAR alpha works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.
Keywords
PROLIFERATOR-ACTIVATED-RECEPTOR, FATTY-ACID OXIDATION, RETINOID-X-RECEPTOR, TYPE-2 DIABETES-MELLITUS, APOLIPOPROTEIN-C-III, NF-KAPPA-B, CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE, PALMITOYLTRANSFERASE-I GENE, LIPOPROTEIN-LIPASE ACTIVITY, CORONARY-ARTERY-DISEASE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 3.60 MB

Citation

Please use this url to cite or link to this publication:

MLA
Bougarne, Nadia et al. “Molecular Actions of PPARα in Lipid Metabolism and Inflammation.” ENDOCRINE REVIEWS 39.5 (2018): 760–802. Print.
APA
Bougarne, N., Weyers, B., Desmet, S., Deckers, J., Ray, D. W., Staels, B., & De Bosscher, K. (2018). Molecular actions of PPARα in lipid metabolism and inflammation. ENDOCRINE REVIEWS, 39(5), 760–802.
Chicago author-date
Bougarne, Nadia, Basiel Weyers, Sofie Desmet, Julie Deckers, David W Ray, Bart Staels, and Karolien De Bosscher. 2018. “Molecular Actions of PPARα in Lipid Metabolism and Inflammation.” Endocrine Reviews 39 (5): 760–802.
Chicago author-date (all authors)
Bougarne, Nadia, Basiel Weyers, Sofie Desmet, Julie Deckers, David W Ray, Bart Staels, and Karolien De Bosscher. 2018. “Molecular Actions of PPARα in Lipid Metabolism and Inflammation.” Endocrine Reviews 39 (5): 760–802.
Vancouver
1.
Bougarne N, Weyers B, Desmet S, Deckers J, Ray DW, Staels B, et al. Molecular actions of PPARα in lipid metabolism and inflammation. ENDOCRINE REVIEWS. 2018;39(5):760–802.
IEEE
[1]
N. Bougarne et al., “Molecular actions of PPARα in lipid metabolism and inflammation,” ENDOCRINE REVIEWS, vol. 39, no. 5, pp. 760–802, 2018.
@article{8577093,
  abstract     = {Peroxisome proliferator-activated receptor a (PPAR alpha) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPAR alpha also exhibits marked anti-inflammatory capacities. The first-generation PPAR alpha agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPAR alpha works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.},
  author       = {Bougarne, Nadia and Weyers, Basiel and Desmet, Sofie and Deckers, Julie and Ray, David W and Staels, Bart and De Bosscher, Karolien},
  issn         = {0163-769X},
  journal      = {ENDOCRINE REVIEWS},
  keywords     = {PROLIFERATOR-ACTIVATED-RECEPTOR,FATTY-ACID OXIDATION,RETINOID-X-RECEPTOR,TYPE-2 DIABETES-MELLITUS,APOLIPOPROTEIN-C-III,NF-KAPPA-B,CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE,PALMITOYLTRANSFERASE-I GENE,LIPOPROTEIN-LIPASE ACTIVITY,CORONARY-ARTERY-DISEASE},
  language     = {eng},
  number       = {5},
  pages        = {760--802},
  title        = {Molecular actions of PPARα in lipid metabolism and inflammation},
  url          = {http://dx.doi.org/10.1210/er.2018-00064},
  volume       = {39},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: