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The emerging application of semi-quantitative and quantitative capillaroscopy in systemic sclerosis

(2018) MICROVASCULAR RESEARCH. 118. p.113-120
Author
Organization
Abstract
Systemic sclerosis (SSc) is a connective tissue disease with high morbidity and mortality, characterized by autoimmunity, obliterative vasculopathy involving mainly the microvasculature, and fibrosis. SSc-specific nailfold capillaroscopic changes have been defined, and nailfold capillaroscopy (NFC) is now unequivocally accepted to be a cornerstone for the early diagnosis of SSc. However, the use of NFC in patients already diagnosed with SSc is still not standardized. Several studies have shown that NFC abnormalities correlate with disease activity and severity and are predictive for disease worsening, such as occurrence of new digital ulcers. More importantly, successful treatment has been shown to diminish NFC abnormalities in severe SSc cases. These findings support the importance of NFC in monitoring patients with SSc and even its role as an outcome measure in SSc clinical trials. It is a matter of debate if Semi-quantitative and Quantitative NFC would be a more sensitive tool than qualitative NFC for meeting these objectives. This review is presenting the emerging application of Semiquantitative and Quantitative NFC in SSc and its potential benefits.
Keywords
CONNECTIVE-TISSUE DISEASE, ULCER RISK INDEX, NAILFOLD VIDEOCAPILLAROSCOPY ASSESSMENT, PULMONARY ARTERIAL-HYPERTENSION, FINGERTIP BLOOD PERFUSION, SEVERE ORGAN INVOLVEMENT, LONG-TERM TREATMENT, RAYNAUDS-PHENOMENON, DIGITAL ULCERS, MICROVASCULAR DAMAGE

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MLA
Mihai, Carina, et al. “The Emerging Application of Semi-Quantitative and Quantitative Capillaroscopy in Systemic Sclerosis.” MICROVASCULAR RESEARCH, vol. 118, 2018, pp. 113–20.
APA
Mihai, C., Smith, V., Dobrota, R., Gheorghiu, A. M., Cutolo, M., & Distler, O. (2018). The emerging application of semi-quantitative and quantitative capillaroscopy in systemic sclerosis. MICROVASCULAR RESEARCH, 118, 113–120.
Chicago author-date
Mihai, Carina, Vanessa Smith, Rucsandra Dobrota, Ana Maria Gheorghiu, Maurizio Cutolo, and Oliver Distler. 2018. “The Emerging Application of Semi-Quantitative and Quantitative Capillaroscopy in Systemic Sclerosis.” MICROVASCULAR RESEARCH 118: 113–20.
Chicago author-date (all authors)
Mihai, Carina, Vanessa Smith, Rucsandra Dobrota, Ana Maria Gheorghiu, Maurizio Cutolo, and Oliver Distler. 2018. “The Emerging Application of Semi-Quantitative and Quantitative Capillaroscopy in Systemic Sclerosis.” MICROVASCULAR RESEARCH 118: 113–120.
Vancouver
1.
Mihai C, Smith V, Dobrota R, Gheorghiu AM, Cutolo M, Distler O. The emerging application of semi-quantitative and quantitative capillaroscopy in systemic sclerosis. MICROVASCULAR RESEARCH. 2018;118:113–20.
IEEE
[1]
C. Mihai, V. Smith, R. Dobrota, A. M. Gheorghiu, M. Cutolo, and O. Distler, “The emerging application of semi-quantitative and quantitative capillaroscopy in systemic sclerosis,” MICROVASCULAR RESEARCH, vol. 118, pp. 113–120, 2018.
@article{8576159,
  abstract     = {Systemic sclerosis (SSc) is a connective tissue disease with high morbidity and mortality, characterized by autoimmunity, obliterative vasculopathy involving mainly the microvasculature, and fibrosis. SSc-specific nailfold capillaroscopic changes have been defined, and nailfold capillaroscopy (NFC) is now unequivocally accepted to be a cornerstone for the early diagnosis of SSc. However, the use of NFC in patients already diagnosed with SSc is still not standardized. Several studies have shown that NFC abnormalities correlate with disease activity and severity and are predictive for disease worsening, such as occurrence of new digital ulcers. More importantly, successful treatment has been shown to diminish NFC abnormalities in severe SSc cases. These findings support the importance of NFC in monitoring patients with SSc and even its role as an outcome measure in SSc clinical trials. It is a matter of debate if Semi-quantitative and Quantitative NFC would be a more sensitive tool than qualitative NFC for meeting these objectives. This review is presenting the emerging application of Semiquantitative and Quantitative NFC in SSc and its potential benefits.},
  author       = {Mihai, Carina and Smith, Vanessa and Dobrota, Rucsandra and Gheorghiu, Ana Maria and Cutolo, Maurizio and Distler, Oliver},
  issn         = {0026-2862},
  journal      = {MICROVASCULAR RESEARCH},
  keywords     = {CONNECTIVE-TISSUE DISEASE,ULCER RISK INDEX,NAILFOLD VIDEOCAPILLAROSCOPY ASSESSMENT,PULMONARY ARTERIAL-HYPERTENSION,FINGERTIP BLOOD PERFUSION,SEVERE ORGAN INVOLVEMENT,LONG-TERM TREATMENT,RAYNAUDS-PHENOMENON,DIGITAL ULCERS,MICROVASCULAR DAMAGE},
  language     = {eng},
  pages        = {113--120},
  title        = {The emerging application of semi-quantitative and quantitative capillaroscopy in systemic sclerosis},
  url          = {http://dx.doi.org/10.1016/j.mvr.2018.03.004},
  volume       = {118},
  year         = {2018},
}

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