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Accelerated repetitive transcranial magnetic stimulation does not influence grey matter volumes in regions related to alcohol relapse : an open-label exploratory study

(2018) DRUG AND ALCOHOL DEPENDENCE. 191. p.210-214
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The integrative neuroscience of behavioral control (Neuroscience)
Abstract
The application of repetitive transcranial magnetic stimulation (rTMS) to prevent relapse in alcohol addiction is currently being evaluated. However, how rTMS may influence the related brain processes is far from clear. Here we wanted to investigate whether baseline grey matter volume (GMV) can predict relapse and whether 15 accelerated high-frequency (HF)- rTMS sessions may influence GMV in areas related to relapse. Voxel-based morphometric (VBM) measurements were used to compare baseline GMV of 22 detoxified, hospitalized, alcohol dependent patients with 22 age and gender matched healthy control subjects. Only patients received 15 accelerated HF-rTMS sessions at the right dorsolateral prefrontal cortex (DLPFC) followed by VBM measurements. Relapse rates were assessed four weeks after the end of the stimulation protocol. At baseline, alcohol-dependent patients overall showed less GMV in diffuse brain areas compared to healthy controls. Relapsers compared to abstainers displayed larger GMV decreases, especially in brain midline structures, insular, hippocampal, and amygdalar areas. Accelerated HF-rTMS treatment had no significant effect on GMV in alcohol-dependent patients, regardless of the relapse state. Although an accelerated HF-rTMS treatment protocol did not influence GMV in alcohol-dependent patients, baseline GMV predicted future relapse.
Keywords
Accelerated HF-rTMS, Alcohol dependence, Voxel-based morphometry, VOXEL-BASED MORPHOMETRY, TREATMENT-RESISTANT DEPRESSION, NONINVASIVE BRAIN-STIMULATION, ANTERIOR CINGULATE CORTEX, HF-RTMS, DEPENDENT PATIENTS, HEAVY DRINKING, INSIGHTS, CONNECTIVITY, IMPACT

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Citation

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Chicago
Wu, Guo-Rong, Chris Baeken, Peter Van Schuerbeek, Johan De Mey, Minghua Bi, and Sarah Herremans. 2018. “Accelerated Repetitive Transcranial Magnetic Stimulation Does Not Influence Grey Matter Volumes in Regions Related to Alcohol Relapse : an Open-label Exploratory Study.” Drug and Alcohol Dependence 191: 210–214.
APA
Wu, G.-R., Baeken, C., Van Schuerbeek, P., De Mey, J., Bi, M., & Herremans, S. (2018). Accelerated repetitive transcranial magnetic stimulation does not influence grey matter volumes in regions related to alcohol relapse : an open-label exploratory study. DRUG AND ALCOHOL DEPENDENCE, 191, 210–214.
Vancouver
1.
Wu G-R, Baeken C, Van Schuerbeek P, De Mey J, Bi M, Herremans S. Accelerated repetitive transcranial magnetic stimulation does not influence grey matter volumes in regions related to alcohol relapse : an open-label exploratory study. DRUG AND ALCOHOL DEPENDENCE. 2018;191:210–4.
MLA
Wu, Guo-Rong et al. “Accelerated Repetitive Transcranial Magnetic Stimulation Does Not Influence Grey Matter Volumes in Regions Related to Alcohol Relapse : an Open-label Exploratory Study.” DRUG AND ALCOHOL DEPENDENCE 191 (2018): 210–214. Print.
@article{8575727,
  abstract     = {The application of repetitive transcranial magnetic stimulation (rTMS) to prevent relapse in alcohol addiction is currently being evaluated. However, how rTMS may influence the related brain processes is far from clear. Here we wanted to investigate whether baseline grey matter volume (GMV) can predict relapse and whether 15 accelerated high-frequency (HF)- rTMS sessions may influence GMV in areas related to relapse. Voxel-based morphometric (VBM) measurements were used to compare baseline GMV of 22 detoxified, hospitalized, alcohol dependent patients with 22 age and gender matched healthy control subjects. Only patients received 15 accelerated HF-rTMS sessions at the right dorsolateral prefrontal cortex (DLPFC) followed by VBM measurements. Relapse rates were assessed four weeks after the end of the stimulation protocol. At baseline, alcohol-dependent patients overall showed less GMV in diffuse brain areas compared to healthy controls. Relapsers compared to abstainers displayed larger GMV decreases, especially in brain midline structures, insular, hippocampal, and amygdalar areas. Accelerated HF-rTMS treatment had no significant effect on GMV in alcohol-dependent patients, regardless of the relapse state. Although an accelerated HF-rTMS treatment protocol did not influence GMV in alcohol-dependent patients, baseline GMV predicted future relapse.},
  author       = {Wu, Guo-Rong and Baeken, Chris and Van Schuerbeek, Peter and De Mey, Johan and Bi, Minghua and Herremans, Sarah},
  issn         = {0376-8716},
  journal      = {DRUG AND ALCOHOL DEPENDENCE},
  language     = {eng},
  pages        = {210--214},
  title        = {Accelerated repetitive transcranial magnetic stimulation does not influence grey matter volumes in regions related to alcohol relapse : an open-label exploratory study},
  url          = {http://dx.doi.org/10.1016/j.drugalcdep.2018.07.004},
  volume       = {191},
  year         = {2018},
}

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