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Abstract
Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite the existence of more than 14,000 scientific publications describing DNA methylation-based biomarkers and their clinical associations in cancer, only 14 of these biomarkers have been translated into a commercially available clinical test. Methodological and experimental obstacles are both major causes of this disparity, but the genomic location of a DNA methylation-based biomarker is an intrinsic and essential property that also has an important and often overlooked role. Here, we examine the importance of the location of DNA methylation for the development of cancer biomarkers, and take a detailed look at the genomic location and other relevant characteristics of the various biomarkers with commercially available tests. We also emphasize the value of publicly available databases for the development of DNA methylation-based biomarkers and the importance of accurate reporting of the full methodological details of research findings.
Keywords
CPG ISLAND HYPERMETHYLATION, CHRONIC LYMPHOCYTIC-LEUKEMIA, PROSTATE-CANCER, PROMOTER METHYLATION, COLORECTAL-CANCER, GSTP1 METHYLATION, GENE-EXPRESSION, GASTRIC-CANCER, BLADDER-CANCER, CELL CARCINOMA

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MLA
Koch, Alexander, Sophie C Joosten, Zheng Feng, et al. “Analysis of DNA Methylation in Cancer : Location Revisited.” NATURE REVIEWS CLINICAL ONCOLOGY 15.7 (2018): 459–466. Print.
APA
Koch, Alexander, Joosten, S. C., Feng, Z., de Ruijter, T. C., Draht, M. X., Melotte, V., Smits, K. M., et al. (2018). Analysis of DNA methylation in cancer : location revisited. NATURE REVIEWS CLINICAL ONCOLOGY, 15(7), 459–466.
Chicago author-date
Koch, Alexander, Sophie C Joosten, Zheng Feng, Tim C de Ruijter, Muriel X Draht, Veerle Melotte, Kim M Smits, et al. 2018. “Analysis of DNA Methylation in Cancer : Location Revisited.” Nature Reviews Clinical Oncology 15 (7): 459–466.
Chicago author-date (all authors)
Koch, Alexander, Sophie C Joosten, Zheng Feng, Tim C de Ruijter, Muriel X Draht, Veerle Melotte, Kim M Smits, Jurgen Veeck, James G Herman, Leander Van Neste, Wim Van Criekinge, Tim De Meyer, and Manon van Engeland. 2018. “Analysis of DNA Methylation in Cancer : Location Revisited.” Nature Reviews Clinical Oncology 15 (7): 459–466.
Vancouver
1.
Koch A, Joosten SC, Feng Z, de Ruijter TC, Draht MX, Melotte V, et al. Analysis of DNA methylation in cancer : location revisited. NATURE REVIEWS CLINICAL ONCOLOGY. 2018;15(7):459–66.
IEEE
[1]
A. Koch et al., “Analysis of DNA methylation in cancer : location revisited,” NATURE REVIEWS CLINICAL ONCOLOGY, vol. 15, no. 7, pp. 459–466, 2018.
@article{8575173,
  abstract     = {Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite the existence of more than 14,000 scientific publications describing DNA methylation-based biomarkers and their clinical associations in cancer, only 14 of these biomarkers have been translated into a commercially available clinical test. Methodological and experimental obstacles are both major causes of this disparity, but the genomic location of a DNA methylation-based biomarker is an intrinsic and essential property that also has an important and often overlooked role. Here, we examine the importance of the location of DNA methylation for the development of cancer biomarkers, and take a detailed look at the genomic location and other relevant characteristics of the various biomarkers with commercially available tests. We also emphasize the value of publicly available databases for the development of DNA methylation-based biomarkers and the importance of accurate reporting of the full methodological details of research findings.},
  author       = {Koch, Alexander and Joosten, Sophie C and Feng, Zheng and de Ruijter, Tim C and Draht, Muriel X and Melotte, Veerle and Smits, Kim M and Veeck, Jurgen and Herman, James G and Van Neste, Leander and Van Criekinge, Wim and De Meyer, Tim and van Engeland, Manon},
  issn         = {1759-4774},
  journal      = {NATURE REVIEWS CLINICAL ONCOLOGY},
  keywords     = {CPG ISLAND HYPERMETHYLATION,CHRONIC LYMPHOCYTIC-LEUKEMIA,PROSTATE-CANCER,PROMOTER METHYLATION,COLORECTAL-CANCER,GSTP1 METHYLATION,GENE-EXPRESSION,GASTRIC-CANCER,BLADDER-CANCER,CELL CARCINOMA},
  language     = {eng},
  number       = {7},
  pages        = {459--466},
  title        = {Analysis of DNA methylation in cancer : location revisited},
  url          = {http://dx.doi.org/10.1038/s41571-018-0004-4},
  volume       = {15},
  year         = {2018},
}

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