Advanced search
1 file | 1.50 MB

Recent advances in devices for vagus nerve stimulation

Ann Mertens (UGent) , Robrecht Raedt (UGent) , Stefanie Gadeyne (UGent) , Evelien Carrette (UGent) , Paul Boon (UGent) and Kristl Vonck (UGent)
Author
Organization
Abstract
Introduction: Vagus nerve stimulation (VNS) has become a valuable treatment option for refractory epilepsy and depression. To improve clinical efficacy and minimize side effects, novel device technology for VNS is under development and investigation.Areas covered: For epilepsy, the AspireSR (R), and SenTiva VNS therapy systems are the two most recently developed VNS devices. These novel devices have implemented a closed-loop approach and contain a cardiac based seizure detection algorithm. The mechanism of action of VNS remains to be further elucidated, but as preclinical research reveals VNS induced effects on brain plasticity, the autonomic nervous system and the inflammatory response, the indications of VNS are expanding. VNS devices are currently being investigated for stroke rehabilitation, treatment of chronic heart failure and rheumatoid arthritis. Recently devices to noninvasively affect vagus nerve functioning have been developed, with the aim of achieving similar effects without the drawbacks of a surgical procedure and continuous stimulation. Expert commentary: Several animal and human trials have shown promising results with minimal adverse events. However, further research needs to be conducted to validate the use of these devices and decide on optimal stimulation parameters.
Keywords
Epilepsy, heart failure, neuromodulation, noninvasive, rheumatoid arthritis, stroke, transcutaneous, vagus nerve stimulation, CHRONIC HEART-FAILURE, CHRONIC CLUSTER HEADACHE, DRUG-RESISTANT EPILEPSY, REFRACTORY EPILEPSY, ELECTRICAL-STIMULATION, HEALTHY-VOLUNTEERS, ICTAL TACHYCARDIA, SEIZURE DETECTION, AURICULAR BRANCH, HF TRIAL

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.50 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Mertens, Ann, Robrecht Raedt, Stefanie Gadeyne, Evelien Carrette, Paul Boon, and Kristl Vonck. 2018. “Recent Advances in Devices for Vagus Nerve Stimulation.” Expert Review of Medical Devices 15 (8): 527–539.
APA
Mertens, Ann, Raedt, R., Gadeyne, S., Carrette, E., Boon, P., & Vonck, K. (2018). Recent advances in devices for vagus nerve stimulation. EXPERT REVIEW OF MEDICAL DEVICES, 15(8), 527–539.
Vancouver
1.
Mertens A, Raedt R, Gadeyne S, Carrette E, Boon P, Vonck K. Recent advances in devices for vagus nerve stimulation. EXPERT REVIEW OF MEDICAL DEVICES. 2018;15(8):527–39.
MLA
Mertens, Ann et al. “Recent Advances in Devices for Vagus Nerve Stimulation.” EXPERT REVIEW OF MEDICAL DEVICES 15.8 (2018): 527–539. Print.
@article{8574565,
  abstract     = {Introduction: Vagus nerve stimulation (VNS) has become a valuable treatment option for refractory epilepsy and depression. To improve clinical efficacy and minimize side effects, novel device technology for VNS is under development and investigation.Areas covered: For epilepsy, the AspireSR (R), and SenTiva VNS therapy systems are the two most recently developed VNS devices. These novel devices have implemented a closed-loop approach and contain a cardiac based seizure detection algorithm. The mechanism of action of VNS remains to be further elucidated, but as preclinical research reveals VNS induced effects on brain plasticity, the autonomic nervous system and the inflammatory response, the indications of VNS are expanding. VNS devices are currently being investigated for stroke rehabilitation, treatment of chronic heart failure and rheumatoid arthritis. Recently devices to noninvasively affect vagus nerve functioning have been developed, with the aim of achieving similar effects without the drawbacks of a surgical procedure and continuous stimulation.
Expert commentary: Several animal and human trials have shown promising results with minimal adverse events. However, further research needs to be conducted to validate the use of these devices and decide on optimal stimulation parameters.},
  author       = {Mertens, Ann and Raedt, Robrecht and Gadeyne, Stefanie and Carrette, Evelien and Boon, Paul and Vonck, Kristl},
  issn         = {1743-4440},
  journal      = {EXPERT REVIEW OF MEDICAL DEVICES},
  keywords     = {Epilepsy,heart failure,neuromodulation,noninvasive,rheumatoid arthritis,stroke,transcutaneous,vagus nerve stimulation,CHRONIC HEART-FAILURE,CHRONIC CLUSTER HEADACHE,DRUG-RESISTANT EPILEPSY,REFRACTORY EPILEPSY,ELECTRICAL-STIMULATION,HEALTHY-VOLUNTEERS,ICTAL TACHYCARDIA,SEIZURE DETECTION,AURICULAR BRANCH,HF TRIAL},
  language     = {eng},
  number       = {8},
  pages        = {527--539},
  title        = {Recent advances in devices for vagus nerve stimulation},
  url          = {http://dx.doi.org/10.1080/17434440.2018.1507732},
  volume       = {15},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: