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Minimising conformational bias in fluoroprolines through vicinal difluorination

(2018) CHEMICAL COMMUNICATIONS. 54(40). p.5118-5121
Author
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Abstract
Monofluorination at the proline 4-position results in conformational effects, which is exploited for a range of applications. However, this conformational distortion is a hindrance when the natural proline conformation is important. Here we introduce (3S,4R)-3,4-difluoroproline, in which the individual fluorine atoms instil opposite conformational effects, as a suitable probe for fluorine NMR studies.
Keywords
AMINO-ACIDS, F-19 NMR, STABILITY, COLLAGEN, PROLINE, PEPTIDE, PROTEINS, CANCER, TOOLS

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Citation

Please use this url to cite or link to this publication:

MLA
Hofman, Gert-Jan et al. “Minimising Conformational Bias in Fluoroprolines Through Vicinal Difluorination.” CHEMICAL COMMUNICATIONS 54.40 (2018): 5118–5121. Print.
APA
Hofman, G.-J., Ottoy, E., Light, M. E., Kieffer, B., Kuprov, I., Martins, J., Sinnaeve, D., et al. (2018). Minimising conformational bias in fluoroprolines through vicinal difluorination. CHEMICAL COMMUNICATIONS, 54(40), 5118–5121.
Chicago author-date
Hofman, Gert-Jan, Emile Ottoy, Mark E Light, Bruno Kieffer, Ilya Kuprov, José Martins, Davy Sinnaeve, and Bruno Linclau. 2018. “Minimising Conformational Bias in Fluoroprolines Through Vicinal Difluorination.” Chemical Communications 54 (40): 5118–5121.
Chicago author-date (all authors)
Hofman, Gert-Jan, Emile Ottoy, Mark E Light, Bruno Kieffer, Ilya Kuprov, José Martins, Davy Sinnaeve, and Bruno Linclau. 2018. “Minimising Conformational Bias in Fluoroprolines Through Vicinal Difluorination.” Chemical Communications 54 (40): 5118–5121.
Vancouver
1.
Hofman G-J, Ottoy E, Light ME, Kieffer B, Kuprov I, Martins J, et al. Minimising conformational bias in fluoroprolines through vicinal difluorination. CHEMICAL COMMUNICATIONS. 2018;54(40):5118–21.
IEEE
[1]
G.-J. Hofman et al., “Minimising conformational bias in fluoroprolines through vicinal difluorination,” CHEMICAL COMMUNICATIONS, vol. 54, no. 40, pp. 5118–5121, 2018.
@article{8573550,
  abstract     = {Monofluorination at the proline 4-position results in conformational effects, which is exploited for a range of applications. However, this conformational distortion is a hindrance when the natural proline conformation is important. Here we introduce (3S,4R)-3,4-difluoroproline, in which the individual fluorine atoms instil opposite conformational effects, as a suitable probe for fluorine NMR studies.},
  author       = {Hofman, Gert-Jan and Ottoy, Emile and Light, Mark E and Kieffer, Bruno and Kuprov, Ilya and Martins, José and Sinnaeve, Davy and Linclau, Bruno},
  issn         = {1359-7345},
  journal      = {CHEMICAL COMMUNICATIONS},
  keywords     = {AMINO-ACIDS,F-19 NMR,STABILITY,COLLAGEN,PROLINE,PEPTIDE,PROTEINS,CANCER,TOOLS},
  language     = {eng},
  number       = {40},
  pages        = {5118--5121},
  title        = {Minimising conformational bias in fluoroprolines through vicinal difluorination},
  url          = {http://dx.doi.org/10.1039/c8cc01493k},
  volume       = {54},
  year         = {2018},
}

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