Advanced search
1 file | 427.44 KB

Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia

Author
Organization
Abstract
Background: Children with acute myeloid leukemia (AML) treated similarly show different toxicity and leukemic responses. We investigated associations between neutrophil recovery time after the first induction course, infection and relapse in children treated according to NOPHO-AML 2004 and DB AML-01. Procedure: Newly diagnosed patients with AML with bone marrow blast<5% between day 15 after the start of the treatment and the start of second induction course, and in complete remission after the second induction course were included (n=279). Neutrophil recovery time was defined as the time from the start of the course to the last day with absolute neutrophil count<0.5x10(9)/l. Linear and Cox regressions were used to investigate associations. Results: Neutrophil recovery time after the first induction course was positively associated with neutrophil recovery time after the remaining courses, and longer neutrophil recovery time (25 days) was associated with increased risk of grade 3-4 infections (hazard ratio 1.4, 95% confidence interval [CI], 1.1-1.8). Longer neutrophil recovery time after the first induction (>30 days) was associated with the increased risk of relapse (5-year cumulative incidence: 48% vs. 42%, hazard ratio 1.7, 95% CI, 1.1-2.6) for cases not treated with hematopoietic stem cell transplantation in first complete remission. Conclusion: Longer neutrophil recovery time after the first induction course was associated with grade 3-4 infections and relapse. If confirmed, this knowledge could be incorporated into risk stratification strategies in pediatric AML.
Keywords
ACUTE LYMPHOBLASTIC-LEUKEMIA, TREATMENT-RELATED MORTALITY, AML RESEARCH, GROUP, INDUCTION THERAPY, CANADIAN INFECTIONS, CHILDREN, PHARMACOKINETICS, CHILDHOOD, REMISSION, DEATHS, acute myeloid leukemia, infection, neutropenia, pediatric cancer, relapse

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 427.44 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Løhmann, Ditte JA, Peter H Asdahl, Jonas Abrahamsson, Shau-Yin Ha, Ólafur G Jónsson, Gertjan JL Kaspers, Minna Koskenvuo, et al. 2018. “Associations Between Neutrophil Recovery Time, Infections and Relapse in Pediatric Acute Myeloid Leukemia.” Pediatric Blood & Cancer 65 (9).
APA
Løhmann, D. J., Asdahl, P. H., Abrahamsson, J., Ha, S.-Y., Jónsson, Ó. G., Kaspers, G. J., Koskenvuo, M., et al. (2018). Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia. PEDIATRIC BLOOD & CANCER, 65(9).
Vancouver
1.
Løhmann DJ, Asdahl PH, Abrahamsson J, Ha S-Y, Jónsson ÓG, Kaspers GJ, et al. Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia. PEDIATRIC BLOOD & CANCER. 2018;65(9).
MLA
Løhmann, Ditte JA, Peter H Asdahl, Jonas Abrahamsson, et al. “Associations Between Neutrophil Recovery Time, Infections and Relapse in Pediatric Acute Myeloid Leukemia.” PEDIATRIC BLOOD & CANCER 65.9 (2018): n. pag. Print.
@article{8573376,
  abstract     = {Background: Children with acute myeloid leukemia (AML) treated similarly show different toxicity and leukemic responses. We investigated associations between neutrophil recovery time after the first induction course, infection and relapse in children treated according to NOPHO-AML 2004 and DB AML-01. 
Procedure: Newly diagnosed patients with AML with bone marrow blast{\textlangle}5\% between day 15 after the start of the treatment and the start of second induction course, and in complete remission after the second induction course were included (n=279). Neutrophil recovery time was defined as the time from the start of the course to the last day with absolute neutrophil count{\textlangle}0.5x10(9)/l. Linear and Cox regressions were used to investigate associations. 
Results: Neutrophil recovery time after the first induction course was positively associated with neutrophil recovery time after the remaining courses, and longer neutrophil recovery time (25 days) was associated with increased risk of grade 3-4 infections (hazard ratio 1.4, 95\% confidence interval [CI], 1.1-1.8). Longer neutrophil recovery time after the first induction ({\textrangle}30 days) was associated with the increased risk of relapse (5-year cumulative incidence: 48\% vs. 42\%, hazard ratio 1.7, 95\% CI, 1.1-2.6) for cases not treated with hematopoietic stem cell transplantation in first complete remission. 
Conclusion: Longer neutrophil recovery time after the first induction course was associated with grade 3-4 infections and relapse. If confirmed, this knowledge could be incorporated into risk stratification strategies in pediatric AML.},
  articleno    = {e27231},
  author       = {L{\o}hmann, Ditte JA and Asdahl, Peter H and Abrahamsson, Jonas and Ha, Shau-Yin and J{\'o}nsson, {\'O}lafur G and Kaspers, Gertjan JL and Koskenvuo, Minna and Lausen, Birgitte and De Moerloose, Barbara and Palle, Josefine and Zeller, Bernward and Hasle, Henrik},
  issn         = {1545-5009},
  journal      = {PEDIATRIC BLOOD \& CANCER},
  language     = {eng},
  number       = {9},
  pages        = {8},
  title        = {Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia},
  url          = {http://dx.doi.org/10.1002/pbc.27231},
  volume       = {65},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: