Advanced search
1 file | 926.95 KB Add to list

Modelling upper respiratory tract diseases : getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies

Author
Organization
Project
ProCure: Defining the future of probiotics for upper respiratory tract diseases
Abstract
Chronic rhinosinusitis (CRS) is a chronic inflammation of the mucosa of the nose and paranasal sinuses affecting approximately 11% of the adult population in Europe. Inadequate immune responses, as well as a dysbiosis of the sinonasal microbiota, have been put forward as aetiological factors of the disease. However, despite the prevalence of this disease, there is no consensus on the aetiology and mechanisms of pathogenesis of CRS. Further research requires in vitro models mimicking the healthy and diseased host environment along with the sinonasal microbiota. This review aims to provide an overview of CRS model systems and proposes in vitro modelling strategies to conduct mechanistic research in an ecological framework on the sinonasal microbiota and its interactions with the host in health and CRS.
Keywords
STAPHYLOCOCCUS-AUREUS BIOFILMS, TASTE RECEPTOR T2R38, NASAL POLYPS, UPPER AIRWAY, SINUS SURGERY, PSEUDOMONAS-AERUGINOSA, HAEMOPHILUS-INFLUENZAE, SINONASAL MICROBIOTA, IMMUNE-RESPONSES, EPITHELIAL-CELLS

Downloads

  • DeRudder 2018 ReviewCRSModels.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 926.95 KB

Citation

Please use this url to cite or link to this publication:

MLA
De Rudder, Charlotte, Marta Calatayud Arroyo, Sarah Lebeer, et al. “Modelling Upper Respiratory Tract Diseases : Getting Grips on Host-microbe Interactions in Chronic Rhinosinusitis Using in Vitro Technologies.” MICROBIOME 6 (2018): n. pag. Print.
APA
De Rudder, C., Calatayud Arroyo, M., Lebeer, S., & Van de Wiele, T. (2018). Modelling upper respiratory tract diseases : getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies. MICROBIOME, 6.
Chicago author-date
De Rudder, Charlotte, Marta Calatayud Arroyo, Sarah Lebeer, and Tom Van de Wiele. 2018. “Modelling Upper Respiratory Tract Diseases : Getting Grips on Host-microbe Interactions in Chronic Rhinosinusitis Using in Vitro Technologies.” Microbiome 6.
Chicago author-date (all authors)
De Rudder, Charlotte, Marta Calatayud Arroyo, Sarah Lebeer, and Tom Van de Wiele. 2018. “Modelling Upper Respiratory Tract Diseases : Getting Grips on Host-microbe Interactions in Chronic Rhinosinusitis Using in Vitro Technologies.” Microbiome 6.
Vancouver
1.
De Rudder C, Calatayud Arroyo M, Lebeer S, Van de Wiele T. Modelling upper respiratory tract diseases : getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies. MICROBIOME. 2018;6.
IEEE
[1]
C. De Rudder, M. Calatayud Arroyo, S. Lebeer, and T. Van de Wiele, “Modelling upper respiratory tract diseases : getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies,” MICROBIOME, vol. 6, 2018.
@article{8573200,
  abstract     = {Chronic rhinosinusitis (CRS) is a chronic inflammation of the mucosa of the nose and paranasal sinuses affecting approximately 11% of the adult population in Europe. Inadequate immune responses, as well as a dysbiosis of the sinonasal microbiota, have been put forward as aetiological factors of the disease. However, despite the prevalence of this disease, there is no consensus on the aetiology and mechanisms of pathogenesis of CRS. Further research requires in vitro models mimicking the healthy and diseased host environment along with the sinonasal microbiota. This review aims to provide an overview of CRS model systems and proposes in vitro modelling strategies to conduct mechanistic research in an ecological framework on the sinonasal microbiota and its interactions with the host in health and CRS.},
  articleno    = {75},
  author       = {De Rudder, Charlotte and Calatayud Arroyo, Marta and Lebeer, Sarah and Van de Wiele, Tom},
  issn         = {2049-2618},
  journal      = {MICROBIOME},
  keywords     = {STAPHYLOCOCCUS-AUREUS BIOFILMS,TASTE RECEPTOR T2R38,NASAL POLYPS,UPPER AIRWAY,SINUS SURGERY,PSEUDOMONAS-AERUGINOSA,HAEMOPHILUS-INFLUENZAE,SINONASAL MICROBIOTA,IMMUNE-RESPONSES,EPITHELIAL-CELLS},
  language     = {eng},
  pages        = {13},
  title        = {Modelling upper respiratory tract diseases : getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies},
  url          = {http://dx.doi.org/10.1186/s40168-018-0462-z},
  volume       = {6},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: