Advanced search

Case-control study of environmental risk factors for Parkinson's disease in Belgium

(2003) EUROPEAN JOURNAL OF EPIDEMIOLOGY. 18(12). p.1133-1142
Author
Organization
Abstract
The aetiology of Parkinson's disease ( PD) is unknown and said to be multifactorial. We report on a retrospective epidemiological case control study, performed in Flanders during a 3- year period, investigating known and potential environmental risk factors for PD by means of questionnaires. We investigated 423 prevalent patients and 205 spouse-controls. We found familial occurrence in 15% of the patients, a mean age of onset of 58 years, and a clear male preponderance ( male/ female ratio 1.53). Our results suggest more nulliparity among female PD patients ( 95% CI: 1.08 - 5.76). We found a discrete clustering of patients in areas with intensive metallurgic activity. Patients were more frequently employed in metallurgy than controls ( 95% CI: 1.04 - 9.20). Furthermore, patients were clearly more exposed to zinc ( 95% CI: 1.51 - 90.90) and toluene ( 95% CI: 1.03 - 58.82). Male patients report more prostatectomy- surgery ( 95% CI: 1.54 - 17.24).
Keywords
diet, gender, organophosphates and comorbidity, pesticides, smoking, MESENCEPHALIC DOPAMINERGIC-NEURONS, DOSE-RESPONSE RELATIONSHIP, MITOCHONDRIAL DYSFUNCTION, DIETARY ANTIOXIDANTS, OXIDATIVE STRESS, EXPOSURE, ETIOLOGY, EPIDEMIOLOGY, PESTICIDES, ESTRADIOL

Citation

Please use this url to cite or link to this publication:

Chicago
Pals, P, B Van Everbroeck, B Grubben, MK Viaene, R Dom, C van der Linden, Patrick Santens, JJ Martin, and P Cras. 2003. “Case-control Study of Environmental Risk Factors for Parkinson’s Disease in Belgium.” European Journal of Epidemiology 18 (12): 1133–1142.
APA
Pals, P., Van Everbroeck, B., Grubben, B., Viaene, M., Dom, R., van der Linden, C., Santens, P., et al. (2003). Case-control study of environmental risk factors for Parkinson’s disease in Belgium. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 18(12), 1133–1142.
Vancouver
1.
Pals P, Van Everbroeck B, Grubben B, Viaene M, Dom R, van der Linden C, et al. Case-control study of environmental risk factors for Parkinson’s disease in Belgium. EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2003;18(12):1133–42.
MLA
Pals, P, B Van Everbroeck, B Grubben, et al. “Case-control Study of Environmental Risk Factors for Parkinson’s Disease in Belgium.” EUROPEAN JOURNAL OF EPIDEMIOLOGY 18.12 (2003): 1133–1142. Print.
@article{8572643,
  abstract     = {The aetiology of Parkinson's disease ( PD) is unknown and said to be multifactorial. We report on a retrospective epidemiological case control study, performed in Flanders during a 3- year period, investigating known and potential environmental risk factors for PD by means of questionnaires. We investigated 423 prevalent patients and 205 spouse-controls. We found familial occurrence in 15\% of the patients, a mean age of onset of 58 years, and a clear male preponderance ( male/ female ratio 1.53). Our results suggest more nulliparity among female PD patients ( 95\% CI: 1.08 - 5.76). We found a discrete clustering of patients in areas with intensive metallurgic activity. Patients were more frequently employed in metallurgy than controls ( 95\% CI: 1.04 - 9.20). Furthermore, patients were clearly more exposed to zinc ( 95\% CI: 1.51 - 90.90) and toluene ( 95\% CI: 1.03 - 58.82). Male patients report more prostatectomy- surgery ( 95\% CI: 1.54 - 17.24).},
  author       = {Pals, P and Van Everbroeck, B and Grubben, B and Viaene, MK and Dom, R and van der Linden, C and Santens, Patrick and Martin, JJ and Cras, P},
  issn         = {0393-2990},
  journal      = {EUROPEAN JOURNAL OF EPIDEMIOLOGY},
  language     = {eng},
  number       = {12},
  pages        = {1133--1142},
  title        = {Case-control study of environmental risk factors for Parkinson's disease in Belgium},
  url          = {http://dx.doi.org/10.1023/b:ejep.0000006639.05690.92},
  volume       = {18},
  year         = {2003},
}

Altmetric
View in Altmetric
Web of Science
Times cited: