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Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma

(2018) BIOLOGY OF THE CELL. 110(8). p.178-195
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Abstract
Background: InformationTumor stroma remodeling is a key feature of malignant tumors and can promote cancer progression. Laminins are major constituents of basement membranes that physically separate the epithelium from the underlying stroma. Results: By employing mouse models expressing high and low levels of the laminin 1 chain (LM1), we highlighted its implication in a tumor-stroma crosstalk, thus leading to increased colon tumor incidence, angiogenesis and tumor growth. The underlying mechanism involves attraction of carcinoma-associated fibroblasts by LM1, VEGFA expression triggered by the complex integrin 21-CXCR4 and binding of VEGFA to LM-111, which in turn promotes angiogenesis, tumor cell survival and proliferation. A gene signature comprising LAMA1, ITGB1, ITGA2, CXCR4 and VEGFA has negative predictive value in colon cancer. Conclusions: Together, we have identified VEGFA, CXCR4 and 21 integrin downstream of LM1 in colon cancer as of bad prognostic value for patient survival. Significance: This information opens novel opportunities for diagnosis and treatment of colon cancer.
Keywords
cancer-associated cancer, colorectal cancer, Laminin 1, tumour angiogenesis, vascular endothelial growth factor, ENDOTHELIAL GROWTH-FACTOR, CHEMOKINE RECEPTOR CXCR4, RETINAL VASCULAR DEVELOPMENT, EXTRACELLULAR-MATRIX, ALPHA-1 CHAIN, CEREBELLAR DYSPLASIA, BASEMENT-MEMBRANES, PANCREATIC-CANCER, CELL-ADHESION, TUMOR-CELL

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Chicago
Mammadova-Bach, Elmina, Tristan Rupp, Caroline Spenlé, Ivo Jivkov, Pattabhiraman Shankaranarayanan, Annick Klein, Laura Pisarsky, et al. 2018. “Laminin Α1 Orchestrates VEGFA Functions in the Ecosystem of Colorectal Carcinoma.” Biology of the Cell 110 (8): 178–195.
APA
Mammadova-Bach, E., Rupp, T., Spenlé, C., Jivkov, I., Shankaranarayanan, P., Klein, A., Pisarsky, L., et al. (2018). Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. BIOLOGY OF THE CELL, 110(8), 178–195.
Vancouver
1.
Mammadova-Bach E, Rupp T, Spenlé C, Jivkov I, Shankaranarayanan P, Klein A, et al. Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. BIOLOGY OF THE CELL. 2018;110(8):178–95.
MLA
Mammadova-Bach, Elmina, Tristan Rupp, Caroline Spenlé, et al. “Laminin Α1 Orchestrates VEGFA Functions in the Ecosystem of Colorectal Carcinoma.” BIOLOGY OF THE CELL 110.8 (2018): 178–195. Print.
@article{8572193,
  abstract     = {Background: InformationTumor stroma remodeling is a key feature of malignant tumors and can promote cancer progression. Laminins are major constituents of basement membranes that physically separate the epithelium from the underlying stroma. 
Results: By employing mouse models expressing high and low levels of the laminin 1 chain (LM1), we highlighted its implication in a tumor-stroma crosstalk, thus leading to increased colon tumor incidence, angiogenesis and tumor growth. The underlying mechanism involves attraction of carcinoma-associated fibroblasts by LM1, VEGFA expression triggered by the complex integrin 21-CXCR4 and binding of VEGFA to LM-111, which in turn promotes angiogenesis, tumor cell survival and proliferation. A gene signature comprising LAMA1, ITGB1, ITGA2, CXCR4 and VEGFA has negative predictive value in colon cancer. 
Conclusions: Together, we have identified VEGFA, CXCR4 and 21 integrin downstream of LM1 in colon cancer as of bad prognostic value for patient survival. 
Significance: This information opens novel opportunities for diagnosis and treatment of colon cancer.},
  author       = {Mammadova-Bach, Elmina and Rupp, Tristan and Spenlé, Caroline and Jivkov, Ivo and Shankaranarayanan, Pattabhiraman and Klein, Annick and Pisarsky, Laura and Méchine-Neuville, Agnès and Cremel, Gérard and Kedinger, Michèle and De Wever, Olivier and Ambartsumian, Noona and Robine, Sylvie and Pencreach, Erwan and Guenot, Dominique and Simon-Assmann, Patricia and Goetz, Jacky G and Orend, Gertraud and Lefebvre, Olivier},
  issn         = {0248-4900},
  journal      = {BIOLOGY OF THE CELL},
  keywords     = {cancer-associated cancer,colorectal cancer,Laminin 1,tumour angiogenesis,vascular endothelial growth factor,ENDOTHELIAL GROWTH-FACTOR,CHEMOKINE RECEPTOR CXCR4,RETINAL VASCULAR DEVELOPMENT,EXTRACELLULAR-MATRIX,ALPHA-1 CHAIN,CEREBELLAR DYSPLASIA,BASEMENT-MEMBRANES,PANCREATIC-CANCER,CELL-ADHESION,TUMOR-CELL},
  language     = {eng},
  number       = {8},
  pages        = {178--195},
  title        = {Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma},
  url          = {http://dx.doi.org/10.1111/boc.201800007},
  volume       = {110},
  year         = {2018},
}

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