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TNF-alpha plays a key role in the regulation of the experimental infection with Trypanosoma brucei

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Abstract
Over the past years, TNF-alpha-induction was shown to be associated with the clinical severity of African trypanosome infections. In this context, a profound study was made in order to analyze (i) the components involved in infection-associated TNF-alpha induction, and (ii) the possible effect of TNF-alpha on the trypanosome itself. Results showed that the variant surface glycoprotein (VSG), released from the trypanosome surface by the activation of a phospholipase C, triggers TNF-alpha secretion by macrophages. On the other hand, the membrane-bound GPI/VSG was found to induce a LPS hypersensitivity in macrophages. Close analysis of the effects of trypanosomiasis-associated TNF-alpha induction in vivo, revealed that TNF-alpha is crucial for the control of the level of parasitaemia. Moreover, it was demonstrated that TNF-alpha exerts a direct in vitro trypanolytic activity on trypanosomes when isolated during the peak stage of infection. Finally, TNF-alpha was found to play a crucial role in the trypanosomiasis-associated induction of suppressive macrophages. Together, these results indicate that trypanosome-induced TNF-alpha-production might play a key role in the infection-associated immunopathology and immunosuppression, and in the outcome of natural trypanosome infections.

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Chicago
Magez, Stefan, A Beschin, Magdalena Radwanska, and P De Baetselier. 1998. “TNF-alpha Plays a Key Role in the Regulation of the Experimental Infection with Trypanosoma Brucei.” In ICOPA IX : 9th International Congress of Parasitology, ed. I Tada, S Kojima, and M Tsuji, 591–595. Bologna, Italy: Medimond.
APA
Magez, S., Beschin, A., Radwanska, M., & De Baetselier, P. (1998). TNF-alpha plays a key role in the regulation of the experimental infection with Trypanosoma brucei. In I. Tada, S. Kojima, & M. Tsuji (Eds.), ICOPA IX : 9th international congress of parasitology (pp. 591–595). Presented at the 9th International congress of Parasitology (ICOPA IX), Bologna, Italy: Medimond.
Vancouver
1.
Magez S, Beschin A, Radwanska M, De Baetselier P. TNF-alpha plays a key role in the regulation of the experimental infection with Trypanosoma brucei. In: Tada I, Kojima S, Tsuji M, editors. ICOPA IX : 9th international congress of parasitology. Bologna, Italy: Medimond; 1998. p. 591–5.
MLA
Magez, Stefan et al. “TNF-alpha Plays a Key Role in the Regulation of the Experimental Infection with Trypanosoma Brucei.” ICOPA IX : 9th International Congress of Parasitology. Ed. I Tada, S Kojima, & M Tsuji. Bologna, Italy: Medimond, 1998. 591–595. Print.
@inproceedings{8572084,
  abstract     = {Over the past years, TNF-alpha-induction was shown to be associated with the clinical severity of African trypanosome infections. In this context, a profound study was made in order to analyze (i) the components involved in infection-associated TNF-alpha induction, and (ii) the possible effect of TNF-alpha on the trypanosome itself. Results showed that the variant surface glycoprotein (VSG), released from the trypanosome surface by the activation of a phospholipase C, triggers TNF-alpha secretion by macrophages. On the other hand, the membrane-bound GPI/VSG was found to induce a LPS hypersensitivity in macrophages. Close analysis of the effects of trypanosomiasis-associated TNF-alpha induction in vivo, revealed that TNF-alpha is crucial for the control of the level of parasitaemia. Moreover, it was demonstrated that TNF-alpha exerts a direct in vitro trypanolytic activity on trypanosomes when isolated during the peak stage of infection. Finally, TNF-alpha was found to play a crucial role in the trypanosomiasis-associated induction of suppressive macrophages. Together, these results indicate that trypanosome-induced TNF-alpha-production might play a key role in the infection-associated immunopathology and immunosuppression, and in the outcome of natural trypanosome infections.},
  author       = {Magez, Stefan and Beschin, A and Radwanska, Magdalena and De Baetselier, P},
  booktitle    = {ICOPA IX : 9th international congress of parasitology},
  editor       = {Tada, I and Kojima, S and Tsuji, M},
  isbn         = {9788832308242},
  language     = {eng},
  location     = {Chiba, Japan},
  pages        = {591--595},
  publisher    = {Medimond},
  title        = {TNF-alpha plays a key role in the regulation of the experimental infection with Trypanosoma brucei},
  year         = {1998},
}

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