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Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections

(1999) INFECTION AND IMMUNITY. 67(6). p.3128-3132
Author
Organization
Abstract
In order to evaluate during experimental Trypanosoma br brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha(-/-)) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites, In the TNF-alpha(-/-) mice, the peak levels of parasitemia were strongly increased compared to the peak levels recorded in wild-type mice. The increased parasite burden did not reflect differences in clearance efficacy or in production of T. brucei-specific immunoglobulin M (IgM) and IgG antibodies. Trypanosome-mediated immunopathological features, such as lymph node-associated immunosuppression and lipopolysaccharide hypersensitivity, were found to be greatly reduced in infected TNF-alpha(-/-) mice. These results demonstrate that, during trypanosome infections, TNF-alpha is a key mediator involved in both parasitemia control and infection-associated pathology.
Keywords
AFRICAN TRYPANOSOMIASIS, IMMUNOSUPPRESSION, INVOLVEMENT, SEVERITY, DISEASE, MICE

Citation

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Chicago
Magez, Stefan, Magdalena Radwanska, A Beschin, K Sekikawa, and P De Baetselier. 1999. “Tumor Necrosis Factor Alpha Is a Key Mediator in the Regulation of Experimental Trypanosoma Brucei Infections.” Infection and Immunity 67 (6): 3128–3132.
APA
Magez, S., Radwanska, M., Beschin, A., Sekikawa, K., & De Baetselier, P. (1999). Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections. INFECTION AND IMMUNITY, 67(6), 3128–3132.
Vancouver
1.
Magez S, Radwanska M, Beschin A, Sekikawa K, De Baetselier P. Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections. INFECTION AND IMMUNITY. 1999;67(6):3128–32.
MLA
Magez, Stefan et al. “Tumor Necrosis Factor Alpha Is a Key Mediator in the Regulation of Experimental Trypanosoma Brucei Infections.” INFECTION AND IMMUNITY 67.6 (1999): 3128–3132. Print.
@article{8572075,
  abstract     = {In order to evaluate during experimental Trypanosoma br brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha(-/-)) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites, In the TNF-alpha(-/-) mice, the peak levels of parasitemia were strongly increased compared to the peak levels recorded in wild-type mice. The increased parasite burden did not reflect differences in clearance efficacy or in production of T. brucei-specific immunoglobulin M (IgM) and IgG antibodies. Trypanosome-mediated immunopathological features, such as lymph node-associated immunosuppression and lipopolysaccharide hypersensitivity, were found to be greatly reduced in infected TNF-alpha(-/-) mice. These results demonstrate that, during trypanosome infections, TNF-alpha is a key mediator involved in both parasitemia control and infection-associated pathology.},
  author       = {Magez, Stefan and Radwanska, Magdalena and Beschin, A and Sekikawa, K and De Baetselier, P},
  issn         = {0019-9567},
  journal      = {INFECTION AND IMMUNITY},
  language     = {eng},
  number       = {6},
  pages        = {3128--3132},
  title        = {Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections},
  volume       = {67},
  year         = {1999},
}

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