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Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study

(2019) EUROPEAN JOURNAL OF NUTRITION. 58(5). p.1947-1960
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Abstract
Aim: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. Methods: In 618 adolescents (13-17years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGF beta-1, C-reactive protein, TNF-alpha, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. Results: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGF beta-1, GGT, and ALT. Conclusion: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.
Keywords
Low-grade inflammation, Adiposity, Mediterranean diet score, Adolescents, POLYUNSATURATED FATTY-ACIDS, GAMMA-GLUTAMYL-TRANSFERASE, HEALTHY LIFE-STYLE, MEDITERRANEAN DIET, ALANINE AMINOTRANSFERASE, EUROPEAN ADOLESCENTS, LIVER-DISEASE, BODY-FAT, INCREASED RISK, CHILDREN

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Citation

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MLA
Arouca, Aline, et al. “Diet as Moderator in the Association of Adiposity with Inflammatory Biomarkers among Adolescents in the HELENA Study.” EUROPEAN JOURNAL OF NUTRITION, vol. 58, no. 5, 2019, pp. 1947–60.
APA
Arouca, A., Moreno, L. A., Gonzalez-Gil, E. M., Marcos, A., Widhalm, K., Molnár, D., … Michels, N. (2019). Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study. EUROPEAN JOURNAL OF NUTRITION, 58(5), 1947–1960.
Chicago author-date
Arouca, Aline, Luis A Moreno, Esther M Gonzalez-Gil, Ascensión Marcos, Kurt Widhalm, Dénes Molnár, Yannis Manios, et al. 2019. “Diet as Moderator in the Association of Adiposity with Inflammatory Biomarkers among Adolescents in the HELENA Study.” EUROPEAN JOURNAL OF NUTRITION 58 (5): 1947–60.
Chicago author-date (all authors)
Arouca, Aline, Luis A Moreno, Esther M Gonzalez-Gil, Ascensión Marcos, Kurt Widhalm, Dénes Molnár, Yannis Manios, Frederic Gottrand, Anthony Kafatos, Mathilde Kersting, Michael Sjöström, Francisco J Amaro-Gahete, Marika Ferrari, Inge Huybrechts, Marcela Gonzalez-Gross, Stefaan De Henauw, and Nathalie Michels. 2019. “Diet as Moderator in the Association of Adiposity with Inflammatory Biomarkers among Adolescents in the HELENA Study.” EUROPEAN JOURNAL OF NUTRITION 58 (5): 1947–1960.
Vancouver
1.
Arouca A, Moreno LA, Gonzalez-Gil EM, Marcos A, Widhalm K, Molnár D, et al. Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study. EUROPEAN JOURNAL OF NUTRITION. 2019;58(5):1947–60.
IEEE
[1]
A. Arouca et al., “Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study,” EUROPEAN JOURNAL OF NUTRITION, vol. 58, no. 5, pp. 1947–1960, 2019.
@article{8571655,
  abstract     = {Aim: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. 
Methods: In 618 adolescents (13-17years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGF beta-1, C-reactive protein, TNF-alpha, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. 
Results: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGF beta-1, GGT, and ALT. 
Conclusion: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.},
  author       = {Arouca, Aline and Moreno, Luis A and Gonzalez-Gil, Esther M and Marcos, Ascensión and Widhalm, Kurt and Molnár, Dénes and Manios, Yannis and Gottrand, Frederic and Kafatos, Anthony and Kersting, Mathilde and Sjöström, Michael and Amaro-Gahete, Francisco J and Ferrari, Marika and Huybrechts, Inge and Gonzalez-Gross, Marcela and De Henauw, Stefaan and Michels, Nathalie},
  issn         = {1436-6207},
  journal      = {EUROPEAN JOURNAL OF NUTRITION},
  keywords     = {Low-grade inflammation,Adiposity,Mediterranean diet score,Adolescents,POLYUNSATURATED FATTY-ACIDS,GAMMA-GLUTAMYL-TRANSFERASE,HEALTHY LIFE-STYLE,MEDITERRANEAN DIET,ALANINE AMINOTRANSFERASE,EUROPEAN ADOLESCENTS,LIVER-DISEASE,BODY-FAT,INCREASED RISK,CHILDREN},
  language     = {eng},
  number       = {5},
  pages        = {1947--1960},
  title        = {Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study},
  url          = {http://dx.doi.org/10.1007/s00394-018-1749-3},
  volume       = {58},
  year         = {2019},
}

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