Advanced search
1 file | 844.53 KB Add to list

Importance of metastatic volume in prognostic models to predict survival in newly diagnosed metastatic prostate cancer

Sarah Buelens (UGent) , Elise De Bleser (UGent) , Bert Dhondt (UGent) , Wesley Verla (UGent) , Karel Decaestecker (UGent) , Piet Ost (UGent) , Valerie Fonteyne (UGent) , Kathia De Man (UGent) , Chloë Standaert (UGent) , Sylvie Rottey (UGent) , et al.
(2019) WORLD JOURNAL OF UROLOGY. 37(12). p.2565-2571
Author
Organization
Abstract
Purpose To explore the prognostic importance of metastatic volume in a contemporary daily practice cohort of patients with newly diagnosed metastatic hormone-naive prostate cancer (mHNPC) and to develop a pragmatic prognostic model to predict survival for these patients. Methods Since 2014, 113 patients with newly diagnosed mHNPC were prospectively registered. Statistical analysis was performed using SPSS 25.0 (TM) with two-sided p value < 0.05 indicating statistical significance. Univariate and multivariate cox regression analyses were performed to identify prognostic risk factors. Kaplan-Meier method with log-rank statistics was constructed to analyze difference in survival in the prognostic groups. Model performance was assessed using the Concordance-index (C-index) and cross-validated in R v3.4.1. High-volume mHNPC (HVD) was defined as the presence of visceral metastasis or >= 4 bone metastases with >= 1 appendicular lesion. Results Multivariate analysis identified HVD (p = 0.047) and elevated alkaline phosphatase (ALP) (p = 0.018) as independent prognostic risk factors for overall survival (OS). Consequently, three prognostic groups were created: a good (no risk factors), intermediate (1 risk factor) and poor prognosis group (2 risk factors). Median OS for the good, intermediate and poor prognosis group was not reached, 73 and 20 months (95% CI 9-31 months with p < 0.001 and Correspondence-index of 0.78), respectively. Conclusions We developed a pragmatic and qualitative prognostic model consisting of three prognostic risk groups for OS in a daily practice cohort of patients with newly diagnosed mHNPC. Independent prognostic risk factors included in the model were HVD and abnormal ALP.
Keywords
Alkaline phosphatase, Hormone-sensitive, Metastatic volume, Overall survival, Predictive model, Prostate cancer, ESTRO-SIOG GUIDELINES, CASTRATION, CARCINOMA, VALIDATION, NOMOGRAM

Downloads

  • (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 844.53 KB

Citation

Please use this url to cite or link to this publication:

MLA
Buelens, Sarah, et al. “Importance of Metastatic Volume in Prognostic Models to Predict Survival in Newly Diagnosed Metastatic Prostate Cancer.” WORLD JOURNAL OF UROLOGY, vol. 37, no. 12, 2019, pp. 2565–71, doi:10.1007/s00345-018-2449-6.
APA
Buelens, S., De Bleser, E., Dhondt, B., Verla, W., Decaestecker, K., Ost, P., … Lumen, N. (2019). Importance of metastatic volume in prognostic models to predict survival in newly diagnosed metastatic prostate cancer. WORLD JOURNAL OF UROLOGY, 37(12), 2565–2571. https://doi.org/10.1007/s00345-018-2449-6
Chicago author-date
Buelens, Sarah, Elise De Bleser, Bert Dhondt, Wesley Verla, Karel Decaestecker, Piet Ost, Valerie Fonteyne, et al. 2019. “Importance of Metastatic Volume in Prognostic Models to Predict Survival in Newly Diagnosed Metastatic Prostate Cancer.” WORLD JOURNAL OF UROLOGY 37 (12): 2565–71. https://doi.org/10.1007/s00345-018-2449-6.
Chicago author-date (all authors)
Buelens, Sarah, Elise De Bleser, Bert Dhondt, Wesley Verla, Karel Decaestecker, Piet Ost, Valerie Fonteyne, Kathia De Man, Chloë Standaert, Sylvie Rottey, and Nicolaas Lumen. 2019. “Importance of Metastatic Volume in Prognostic Models to Predict Survival in Newly Diagnosed Metastatic Prostate Cancer.” WORLD JOURNAL OF UROLOGY 37 (12): 2565–2571. doi:10.1007/s00345-018-2449-6.
Vancouver
1.
Buelens S, De Bleser E, Dhondt B, Verla W, Decaestecker K, Ost P, et al. Importance of metastatic volume in prognostic models to predict survival in newly diagnosed metastatic prostate cancer. WORLD JOURNAL OF UROLOGY. 2019;37(12):2565–71.
IEEE
[1]
S. Buelens et al., “Importance of metastatic volume in prognostic models to predict survival in newly diagnosed metastatic prostate cancer,” WORLD JOURNAL OF UROLOGY, vol. 37, no. 12, pp. 2565–2571, 2019.
@article{8571574,
  abstract     = {{Purpose To explore the prognostic importance of metastatic volume in a contemporary daily practice cohort of patients with newly diagnosed metastatic hormone-naive prostate cancer (mHNPC) and to develop a pragmatic prognostic model to predict survival for these patients.
Methods Since 2014, 113 patients with newly diagnosed mHNPC were prospectively registered. Statistical analysis was performed using SPSS 25.0 (TM) with two-sided p value < 0.05 indicating statistical significance. Univariate and multivariate cox regression analyses were performed to identify prognostic risk factors. Kaplan-Meier method with log-rank statistics was constructed to analyze difference in survival in the prognostic groups. Model performance was assessed using the Concordance-index (C-index) and cross-validated in R v3.4.1. High-volume mHNPC (HVD) was defined as the presence of visceral metastasis or >= 4 bone metastases with >= 1 appendicular lesion.
Results Multivariate analysis identified HVD (p = 0.047) and elevated alkaline phosphatase (ALP) (p = 0.018) as independent prognostic risk factors for overall survival (OS). Consequently, three prognostic groups were created: a good (no risk factors), intermediate (1 risk factor) and poor prognosis group (2 risk factors). Median OS for the good, intermediate and poor prognosis group was not reached, 73 and 20 months (95% CI 9-31 months with p < 0.001 and Correspondence-index of 0.78), respectively.
Conclusions We developed a pragmatic and qualitative prognostic model consisting of three prognostic risk groups for OS in a daily practice cohort of patients with newly diagnosed mHNPC. Independent prognostic risk factors included in the model were HVD and abnormal ALP.}},
  author       = {{Buelens, Sarah and De Bleser, Elise and Dhondt, Bert and Verla, Wesley and Decaestecker, Karel and Ost, Piet and Fonteyne, Valerie and De Man, Kathia and Standaert, Chloë and Rottey, Sylvie and Lumen, Nicolaas}},
  issn         = {{0724-4983}},
  journal      = {{WORLD JOURNAL OF UROLOGY}},
  keywords     = {{Alkaline phosphatase,Hormone-sensitive,Metastatic volume,Overall survival,Predictive model,Prostate cancer,ESTRO-SIOG GUIDELINES,CASTRATION,CARCINOMA,VALIDATION,NOMOGRAM}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2565--2571}},
  title        = {{Importance of metastatic volume in prognostic models to predict survival in newly diagnosed metastatic prostate cancer}},
  url          = {{http://dx.doi.org/10.1007/s00345-018-2449-6}},
  volume       = {{37}},
  year         = {{2019}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: