Advanced search
1 file | 1.80 MB

Herpesvirus evasion of natural killer cells

Author
Organization
Abstract
Natural killer (NK) cells play an important role in the host response against viral infections and cancer development. They are able to kill virus-infected and tumor cells, and they produce different important cytokines that stimulate the antiviral and antitumor adaptive immune response, particularly interferon gamma. NK cells are of particular importance in herpesvirus infections, which is illustrated by systemic and life-threatening herpesvirus disease symptoms in patients with deficiencies in NK cell activity and by the myriad of reports describing herpesvirus NK cell evasion strategies. The latter is particularly obvious for cytomegaloviruses, but increasing evidence indicates that most, if not all, members of the herpesvirus family suppress NK cell activity to some extent. This review discusses the different NK cell evasion strategies described for herpesviruses and how this knowledge may translate to clinical applications.
Keywords
EBV, KSHV, NK cell, cytomegalovirus, evasion, herpesvirus, herpes simplex virus, natural killer cells, pseudorabies virus, VIRUS-INFECTED CELLS, CYTOMEGALOVIRUS UL16 GLYCOPROTEIN, MISSING SELF-RECOGNITION, NKG2D LIGAND EXPRESSION, VARICELLA-ZOSTER-VIRUS, I-RELATED MOLECULES, NK CELLS, HLA-E, MURINE CYTOMEGALOVIRUS, DOWN-REGULATION

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.80 MB

Citation

Please use this url to cite or link to this publication:

Chicago
De Pelsmaeker, Steffi, Nicolás Romero Rata, Massimo Vitale, and Herman Favoreel. 2018. “Herpesvirus Evasion of Natural Killer Cells.” Journal of Virology 92 (11).
APA
De Pelsmaeker, Steffi, Romero Rata, N., Vitale, M., & Favoreel, H. (2018). Herpesvirus evasion of natural killer cells. JOURNAL OF VIROLOGY, 92(11).
Vancouver
1.
De Pelsmaeker S, Romero Rata N, Vitale M, Favoreel H. Herpesvirus evasion of natural killer cells. JOURNAL OF VIROLOGY. 2018;92(11).
MLA
De Pelsmaeker, Steffi, Nicolás Romero Rata, Massimo Vitale, et al. “Herpesvirus Evasion of Natural Killer Cells.” JOURNAL OF VIROLOGY 92.11 (2018): n. pag. Print.
@article{8571475,
  abstract     = {Natural killer (NK) cells play an important role in the host response against viral infections and cancer development. They are able to kill virus-infected and tumor cells, and they produce different important cytokines that stimulate the antiviral and antitumor adaptive immune response, particularly interferon gamma. NK cells are of particular importance in herpesvirus infections, which is illustrated by systemic and life-threatening herpesvirus disease symptoms in patients with deficiencies in NK cell activity and by the myriad of reports describing herpesvirus NK cell evasion strategies. The latter is particularly obvious for cytomegaloviruses, but increasing evidence indicates that most, if not all, members of the herpesvirus family suppress NK cell activity to some extent. This review discusses the different NK cell evasion strategies described for herpesviruses and how this knowledge may translate to clinical applications.},
  articleno    = {e02105-17},
  author       = {De Pelsmaeker, Steffi and Romero Rata, Nicol{\'a}s and Vitale, Massimo and Favoreel, Herman},
  issn         = {0022-538X},
  journal      = {JOURNAL OF VIROLOGY},
  language     = {eng},
  number       = {11},
  pages        = {19},
  title        = {Herpesvirus evasion of natural killer cells},
  url          = {http://dx.doi.org/10.1128/jvi.02105-17},
  volume       = {92},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: