Transgenerational inheritance of DNA hypomethylation in Daphnia magna in response to salinity stress
- Author
- Guilherme Jeremias, João Barbosa, Sergio Marques, Karel De Schamphelaere (UGent) , Filip Van Nieuwerburgh (UGent) , Dieter Deforce (UGent) , Fernando Gonçalves, Joana Pereira and Jana Asselman (UGent)
- Organization
- Abstract
- Epigenetic mechanisms have been found to play important roles in environmental stress response and regulation. These can, theoretically, be transmitted to future unexposed generations, yet few studies have shown persisting stress-induced transgenerational effects, particularly in invertebrates. Here, we focus on the aquatic microcrustacean Daphnia, a parthenogenetic model species, and its response to salinity stress. Salinity is a serious threat to freshwater ecosystems and a relevant form of environmental perturbation affecting freshwater ecosystems. We exposed one generation of D. magna to high levels of salinity (F0) and found that the exposure provoked specific methylation patterns that were transferred to the three consequent nonexposed generations (F1, F2, and F3). This was the case for the hypomethylation of six protein-coding genes with important roles in the organisms' response to environmental change: DNA damage repair, cytoskeleton organization, and protein synthesis. This suggests that epigenetic changes in Daphnia are particularly targeted to genes involved in coping with general cellular stress responses. Our results highlight that epigenetic marks are affected by environmental stressors and can be transferred to subsequent unexposed generations. Epigenetic marks could therefore prove to be useful indicators of past or historic pollution in this parthenogenetic model system. Furthermore, no life history costs seem to be associated with the maintenance of hypomethylation across unexposed generations in Daphnia following a single stress exposure.
- Keywords
- LIFE-HISTORY RESPONSES, GENE BODY METHYLATION, ROAD SALT, DIFFERENTIAL METHYLATION, EPIGENETIC INHERITANCE, SIMOCEPHALUS-VETULUS, ARABIDOPSIS-THALIANA, GENOME-WIDE, COENZYME-Q, TOLERANCE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8570919
- MLA
- Jeremias, Guilherme, João Barbosa, Sergio Marques, et al. “Transgenerational Inheritance of DNA Hypomethylation in Daphnia Magna in Response to Salinity Stress.” ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.17 (2018): 10114–10123. Print.
- APA
- Jeremias, G., Barbosa, J., Marques, S., De Schamphelaere, K., Van Nieuwerburgh, F., Deforce, D., Gonçalves, F., et al. (2018). Transgenerational inheritance of DNA hypomethylation in Daphnia magna in response to salinity stress. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 52(17), 10114–10123.
- Chicago author-date
- Jeremias, Guilherme, João Barbosa, Sergio Marques, Karel De Schamphelaere, Filip Van Nieuwerburgh, Dieter Deforce, Fernando Gonçalves, Joana Pereira, and Jana Asselman. 2018. “Transgenerational Inheritance of DNA Hypomethylation in Daphnia Magna in Response to Salinity Stress.” Environmental Science & Technology 52 (17): 10114–10123.
- Chicago author-date (all authors)
- Jeremias, Guilherme, João Barbosa, Sergio Marques, Karel De Schamphelaere, Filip Van Nieuwerburgh, Dieter Deforce, Fernando Gonçalves, Joana Pereira, and Jana Asselman. 2018. “Transgenerational Inheritance of DNA Hypomethylation in Daphnia Magna in Response to Salinity Stress.” Environmental Science & Technology 52 (17): 10114–10123.
- Vancouver
- 1.Jeremias G, Barbosa J, Marques S, De Schamphelaere K, Van Nieuwerburgh F, Deforce D, et al. Transgenerational inheritance of DNA hypomethylation in Daphnia magna in response to salinity stress. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2018;52(17):10114–23.
- IEEE
- [1]G. Jeremias et al., “Transgenerational inheritance of DNA hypomethylation in Daphnia magna in response to salinity stress,” ENVIRONMENTAL SCIENCE & TECHNOLOGY, vol. 52, no. 17, pp. 10114–10123, 2018.
@article{8570919,
abstract = {Epigenetic mechanisms have been found to play important roles in environmental stress response and regulation. These can, theoretically, be transmitted to future unexposed generations, yet few studies have shown persisting stress-induced transgenerational effects, particularly in invertebrates. Here, we focus on the aquatic microcrustacean Daphnia, a parthenogenetic model species, and its response to salinity stress. Salinity is a serious threat to freshwater ecosystems and a relevant form of environmental perturbation affecting freshwater ecosystems. We exposed one generation of D. magna to high levels of salinity (F0) and found that the exposure provoked specific methylation patterns that were transferred to the three consequent nonexposed generations (F1, F2, and F3). This was the case for the hypomethylation of six protein-coding genes with important roles in the organisms' response to environmental change: DNA damage repair, cytoskeleton organization, and protein synthesis. This suggests that epigenetic changes in Daphnia are particularly targeted to genes involved in coping with general cellular stress responses. Our results highlight that epigenetic marks are affected by environmental stressors and can be transferred to subsequent unexposed generations. Epigenetic marks could therefore prove to be useful indicators of past or historic pollution in this parthenogenetic model system. Furthermore, no life history costs seem to be associated with the maintenance of hypomethylation across unexposed generations in Daphnia following a single stress exposure.},
author = {Jeremias, Guilherme and Barbosa, João and Marques, Sergio and De Schamphelaere, Karel and Van Nieuwerburgh, Filip and Deforce, Dieter and Gonçalves, Fernando and Pereira, Joana and Asselman, Jana},
issn = {0013-936X},
journal = {ENVIRONMENTAL SCIENCE & TECHNOLOGY},
keywords = {LIFE-HISTORY RESPONSES,GENE BODY METHYLATION,ROAD SALT,DIFFERENTIAL METHYLATION,EPIGENETIC INHERITANCE,SIMOCEPHALUS-VETULUS,ARABIDOPSIS-THALIANA,GENOME-WIDE,COENZYME-Q,TOLERANCE},
language = {eng},
number = {17},
pages = {10114--10123},
title = {Transgenerational inheritance of DNA hypomethylation in Daphnia magna in response to salinity stress},
url = {http://dx.doi.org/10.1021/acs.est.8b03225},
volume = {52},
year = {2018},
}
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