@article{8570474,
  abstract     = {{Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.}},
  articleno    = {{eaap8757}},
  author       = {{Anttila, Verneri and Bulik-Sullivan, Brendan and Finucane, Hilary K and Walters, Raymond K and Bras, Jose and Duncan, Laramie and Escott-Price, Valentina and Falcone, Guido J and Gormley, Padhraig and Malik, Rainer and Patsopoulos, Nikolaos A and Ripke, Stephan and Wei, Zhi and Yu, Dongmei and Lee, Phil H and Turley, Patrick and Grenier-Boley, Benjamin and Chouraki, Vincent and Kamatani, Yoichiro and Berr, Claudine and Letenneur, Luc and Hannequin, Didier and Amouyel, Philippe and Boland, Anne and Deleuze, Jean-Francois and Duron, Emmanuelle and Vardarajan, Badri N and Reitz, Christiane and Goate, Alison M and Huentelman, Matthew J and Kamboh, M Ilyas and Larson, Eric B and Rogaeva, Ekaterina and St George-Hyslop, Peter and Hakonarson, Hakon and Kukull, Walter A and Farrer, Lindsay A and Barnes, Lisa L and Beach, Thomas G and Demirci, F Yesim and Head, Elizabeth and Hulette, Christine M and Jicha, Gregory A and Kauwe, John SK and Kaye, Jeffrey A and Leverenz, James B and Levey, Allan I and Lieberman, Andrew P and Pankratz, Vernon S and Poon, Wayne W and Quinn, Joseph F and Saykin, Andrew J and Schneider, Lon S and Smith, Amanda G and Sonnen, Joshua A and Stern, Robert A and Van Deerlin, Vivianna M and Van Eldik, Linda J and Harold, Denise and Russo, Giancarlo and Rubinsztein, David C and Bayer, Anthony and Tsolaki, Magda and Proitsi, Petra and Fox, Nick C and Hampel, Harald and Owen, Michael J and Mead, Simon and Passmore, Peter and Morgan, Kevin and Noethen, Markus M and Rossor, Martin and Lupton, Michelle K and Hoffmann, Per and Kornhuber, Johannes and Lawlor, Brian and McQuillin, Andrew and Al-Chalabi, Ammar and Bis, Joshua C and Ruiz, Agustin and Boada, Merce and Seshadri, Sudha and Beiser, Alexa and Rice, Kenneth and van der Lee, Sven J and De Jager, Philip L and Geschwind, Daniel H and Riemenschneider, Matthias and Riedel-Heller, Steffi and Rotter, Jerome I and Ransmayr, Gerhard and Hyman, Bradley T and Cruchaga, Carlos and Alegret, Montserrat and Winsvold, Bendik and Palta, Priit and Farh, Kai-How and Cuenca-Leon, Ester and Furlotte, Nicholas and Kurth, Tobias and Ligthart, Lannie and Terwindt, Gisela M and Freilinger, Tobias and Ran, Caroline and Gordon, Scott D and Borck, Guntram and Adams, Hieab HH and Lehtimaki, Terho and Wedenoja, Juho and Buring, Julie E and Schuerks, Markus and Hrafnsdottir, Maria and Hottenga, Jouke-Jan and Penninx, Brenda and Artto, Ville and Kaunisto, Mari and Vepsalainen, Salli and Martin, Nicholas G and Montgomery, Grant W and Kurki, Mitja I and Hamalainen, Eija and Huang, Hailiang and Huang, Jie and Sandor, Cynthia and Webber, Caleb and Muller-Myhsok, Bertram and Schreiber, Stefan and Salomaa, Veikko and Loehrer, Elizabeth and Goebel, Hartmut and Macaya, Alfons and Pozo-Rosich, Patricia and Hansen, Thomas and Werge, Thomas and Kaprio, Jaakko and Metspalu, Andres and Kubisch, Christian and Ferrari, Michel D and Belin, Andrea C and van den Maagdenberg, Arn MJM and Zwart, John-Anker and Boomsma, Dorret and Eriksson, Nicholas and Olesen, Jes and Chasman, Daniel I and Nyholt, Dale R and Avbersek, Andreja and Baum, Larry and Berkovic, Samuel and Bradfield, Jonathan and Buono, Russell and Catarino, Claudia B and Cossette, Patrick and De Jonghe, Peter and Depondt, Chantal and Dlugos, Dennis and Ferraro, Thomas N and French, Jacqueline and Hjalgrim, Helle and Jamnadas-Khoda, Jennifer and Kalviainen, Reetta and Kunz, Wolfram S and Lerche, Holger and Leu, Costin and Lindhout, Dick and Lo, Warren and Lowenstein, Daniel and McCormack, Mark and Moller, Rikke S and Molloy, Anne and Ng, Ping-Wing and Oliver, Karen and Privitera, Michael and Radtke, Rodney and Ruppert, Ann-Kathrin and Sander, Thomas and Schachter, Steven and Schankin, Christoph and Scheffer, Ingrid and Schoch, Susanne and Sisodiya, Sanjay M and Smith, Philip and Sperling, Michael and Striano, Pasquale and Surges, Rainer and Thomas, G Neil and Visscher, Frank and Whelan, Christopher D and Zara, Federico and Heinzen, Erin L and Marson, Anthony and Becker, Felicitas and Stroink, Hans and Zimprich, Fritz and Gasser, Thomas and Gibbs, Raphael and Heutink, Peter and Martinez, Maria and Morris, Huw R and Sharma, Manu and Ryten, Mina and Mok, Kin Y and Pulit, Sara and Bevan, Steve and Holliday, Elizabeth and Attia, John and Battey, Thomas and Boncoraglio, Giorgio and Thijs, Vincent and Chen, Wei-Min and Mitchell, Braxton and Rothwell, Peter and Sharma, Pankaj and Sudlow, Cathie and Vicente, Astrid and Markus, Hugh and Kourkoulis, Christina and Pera, Joana and Raffeld, Miriam and Silliman, Scott and Perica, Vesna Boraska and Thornton, Laura M and Huckins, Laura M and Rayner, N William and Lewis, Cathryn M and Gratacos, Monica and Rybakowski, Filip and Keski-Rahkonen, Anna and Raevuori, Anu and Hudson, James I and Reichborn-Kjennerud, Ted and Monteleone, Palmiero and Karwautz, Andreas and Mannik, Katrin and Baker, Jessica H and O'Toole, Julie K and Trace, Sara E and Davis, Oliver SP and Helder, Sietske G and Ehrlich, Stefan and Herpertz-Dahlmann, Beate and Danner, Unna N and van Elburg, Annemarie A and Clementi, Maurizio and Forzan, Monica and Docampo, Elisa and Lissowska, Jolanta and Hauser, Joanna and Tortorella, Alfonso and Maj, Mario and Gonidakis, Fragiskos and Tziouvas, Konstantinos and Papezova, Hana and Yilmaz, Zeynep and Wagner, Gudrun and Cohen-Woods, Sarah and Herms, Stefan and Julia, Antonio and Rabionet, Raquel and Dick, Danielle M and Ripatti, Samuli and Andreassen, Ole A and Espeseth, Thomas and Lundervold, Astri J and Steen, Vidar M and Pinto, Dalila and Scherer, Stephen W and Aschauer, Harald and Schosser, Alexandra and Alfredsson, Lars and Padyukov, Leonid and Halmi, Katherine A and Mitchell, James and Strober, Michael and Bergen, Andrew W and Kaye, Walter and Szatkiewicz, Jin Peng and Cormand, Bru and Antoni Ramos-Quiroga, Josep and Sanchez-Mora, Cristina and Ribases, Marta and Casas, Miguel and Hervas, Amaia and Jesus Arranz, Maria and Haavik, Jan and Zayats, Tetyana and Johansson, Stefan and Williams, Nigel and Dempfle, Astrid and Rothenberger, Aribert and Kuntsi, Jonna and Oades, Robert D and Banaschewski, Tobias and Franke, Barbara and Buitelaar, Jan K and Arias Vasquez, Alejandro and Doyle, Alysa E and Reif, Andreas and Lesch, Klaus-Peter and Freitag, Christine and Rivero, Olga and Palmason, Haukur and Romanos, Marcel and Langley, Kate and Rietschel, Marcella and Witt, Stephanie H and Dalsgaard, Soeren and Borglum, Anders D and Waldman, Irwin and Wilmot, Beth and Molly, Nikolas and Bau, Claiton HD and Crosbie, Jennifer and Schachar, Russell and K., Sandra and McGough, James J and Grevet, Eugenio H and Medland, Sarah E and Robinson, Elise and Weiss, Lauren A and Bacchelli, Elena and Bailey, Anthony and Bal, Vanessa and Battaglia, Agatino and Betancur, Catalina and Bolton, Patrick and Cantor, Rita and Celestino-Soper, Patricia and Dawson, Geraldine and De Rubeis, Silvia and Duque, Frederico and Green, Andrew and Klauck, Sabine M and Leboyer, Marion and Levitt, Pat and Maestrini, Elena and Mane, Shrikant and Moreno-De-Luca, Daniel and Parr, Jeremy and Regan, Regina and Reichenberg, Abraham and Sandin, Sven and Vorstman, Jacob and Wassink, Thomas and Wijsman, Ellen and Cook, Edwin and Santangelo, Susan and Delorme, Richard and Roge, Bernadette and Magalhaes, Tiago and Arking, Dan and Schulze, Thomas G and Thompson, Robert C and Strohmaier, Jana and Matthews, Keith and Melle, Ingrid and Morris, Derek and Blackwood, Douglas and McIntosh, Andrew and Bergen, Sarah E and Schalling, Martin and Jamain, Stephane and Maaser, Anna and Fischer, Sascha B and Reinbold, Celine S and Fullerton, Janice M and Guzman-Parra, Jose and Mayoral, Fermin and Schofield, Peter R and Cichon, Sven and Muhleisen, Thomas W and Degenhardt, Franziska and Schumacher, Johannes and Bauer, Michael and Mitchell, Philip B and Gershon, Elliot S and Rice, John and Potash, James B and Zandi, Peter P and Craddock, Nick and Ferrier, I Nicol and Alda, Martin and Rouleau, Guy A and Turecki, Gustavo and Ophoff, Roel and Pato, Carlos and Anjorin, Adebayo and Stahl, Eli and Leber, Markus and Czerski, Piotr M and Cruceanu, Cristiana and Jones, Ian R and Posthuma, Danielle and Andlauer, Till FM and Forstner, Andreas J and Streit, Fabian and Baune, Bernhard T and Air, Tracy and Sinnamon, Grant and Wray, Naomi R and MacIntyre, Donald J and Porteous, David and Homuth, Georg and Rivera, Margarita and Grove, Jakob and Middeldorp, Christel M and Hickie, Ian and Pergadia, Michele and Mehta, Divya and Smit, Johannes H and Jansen, Rick and de Geus, Eco and Dunn, Erin and Li, Qingqin S and Nauck, Matthias and Schoevers, Robert A and Beekman, Aartjan TF and Knowles, James A and Viktorin, Alexander and Arnold, Paul and Barr, Cathy L and Bedoya-Berrio, Gabriel and Bienvenu, O Joseph and Brentani, Helena and Burton, Christie and Camarena, Beatriz and Cappi, Carolina and Cath, Danielle and Cavallini, Maria and Cusi, Daniele and Darrow, Sabrina and Denys, Damiaan and Derks, Eske M and Dietrich, Andrea and Fernandez, Thomas and Figee, Martijn and Freimer, Nelson and Gerber, Gloria and Grados, Marco and Greenberg, Erica and Hanna, Gregory L and Hartmann, Andreas and Hirschtritt, Matthew E and Hoekstra, Pieter J and Huang, Alden and Huyser, Chaim and Illmann, Cornelia and Jenike, Michael and Kuperman, Samuel and Leventhal, Bennett and Lochner, Christine and Lyon, Gholson J and Macciardi, Fabio and Madruga-Garrido, Marcos and Malaty, Irene A and Maras, Athanasios and McGrath, Lauren and Miguel, Euripedes C and Mir, Pablo and Nestadt, Gerald and Nicolini, Humberto and Okun, Michael S and Pakstis, Andrew and Paschou, Peristera and Piacentini, John and Pittenger, Christopher and Plessen, Kerstin and Ramensky, Vasily and Ramos, Eliana M and Reus, Victor and Richter, Margaret A and Riddle, Mark A and Robertson, Mary M and Roessner, Veit and Rosario, Maria and Samuels, Jack F and Sandor, Paul and Stein, Dan J and Tsetsos, Fotis and Van Nieuwerburgh, Filip and Weatherall, Sarah and Wendland, Jens R and Wolanczyk, Tomasz and Worbe, Yulia and Zai, Gwyneth and Goes, Fernando S and McLaughlin, Nicole and Nestadt, Paul S and Grabe, Hans-Jorgen and Depienne, Christel and Konkashbaev, Anuar and Lanzagorta, Nuria and Valencia-Duarte, Ana and Bramon, Elvira and Buccola, Nancy and Cahn, Wiepke and Cairns, Murray and Chong, Siow A and Cohen, David and Crespo-Facorro, Benedicto and Crowley, James and Davidson, Michael and DeLisi, Lynn and Dinan, Timothy and Donohoe, Gary and Drapeau, Elodie and Duan, Jubao and Haan, Lieuwe and Hougaard, David and Karachanak-Yankova, Sena and Khrunin, Andrey and Klovins, Janis and Kucinskas, Vaidutis and Keong, Jimmy Lee Chee and Limborska, Svetlana and Loughland, Carmel and Lonnqvist, Jouko and Maher, Brion and Mattheisen, Manuel and McDonald, Colm and Murphy, Kieran C and Nenadic, Igor and van Os, Jim and Pantelis, Christos and Pato, Michele and Petryshen, Tracey and Quested, Digby and Roussos, Panos and Sanders, Alan R and Schall, Ulrich and Schwab, Sibylle G and Sim, Kang and So, Hon-Cheong and Stoegmann, Elisabeth and Subramaniam, Mythily and Toncheva, Draga and Waddington, John and Walters, James and Weiser, Mark and Cheng, Wei and Cloninger, Robert and Curtis, David and Gejman, Pablo V and Henskens, Frans and Mattingsdal, Morten and Oh, Sang-Yun and Scott, Rodney and Webb, Bradley and Breen, Gerome and Churchhouse, Claire and Bulik, Cynthia M and Daly, Mark and Dichgans, Martin and Faraone, Stephen V and Guerreiro, Rita and Holmans, Peter and Kendler, Kenneth S and Koeleman, Bobby and Mathews, Carol A and Price, Alkes and Scharf, Jeremiah and Sklar, Pamela and Williams, Julie and Wood, Nicholas W and Cotsapas, Chris and Palotie, Aarno and Smoller, Jordan W and Sullivan, Patrick and Rosand, Jonathan and Corvin, Aiden and Neale, Benjamin M}},
  issn         = {{0036-8075}},
  journal      = {{SCIENCE}},
  keywords     = {{GENOME-WIDE ASSOCIATION,DEFICIT HYPERACTIVITY DISORDER,MAJOR,DEPRESSIVE DISORDER,POPULATION-BASED TWIN,LONG-TERM SURVIVAL,BODY-MASS INDEX,ALZHEIMERS-DISEASE,ANOREXIA-NERVOSA,BIPOLAR DISORDER,GENETIC CORRELATIONS}},
  language     = {{eng}},
  number       = {{6395}},
  pages        = {{12}},
  title        = {{Analysis of shared heritability in common disorders of the brain}},
  url          = {{http://doi.org/10.1126/science.aap8757}},
  volume       = {{360}},
  year         = {{2018}},
}

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