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Performance evaluation of the LightPath imaging system for intra-operative Cerenkov luminescence imaging

Esther Ciarrocchi, Christian Vanhove (UGent) , Benedicte Descamps (UGent) , Stef De Lombaerde, Stefaan Vandenberghe (UGent) and Nicola Belcari
(2018) PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS. 52. p.122-128
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Abstract
The performances of an intra-operative optical imaging system for Cerenkov luminescence imaging of resected tumor specimens were evaluated with phantom studies. The spatial resolution, the linearity of the measured signal with the activity concentration and the minimum detectable activity concentration were considered. A high linearity was observed over a broad range of activity concentration (R-2 >= 0.99 down to similar to 40 kBq/ml of F-18-FDG). For F-18-FDG activity distributions 2 mm deep in biological tissue, the measured detection limit was 8 kBq/ml and a spatial resolution of 2.5 mm was obtained. The detection limit of the imaging system is comparable with clinical activity concentrations in tumor specimens, and the spatial resolution is compatible with clinical requirements.
Keywords
Cerenkov luminescence imaging, Intra-operative imaging, Performance evaluation, Beta-emitting radiotracer, IN-VIVO, RADIOTRACERS, F-18-FDG

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MLA
Ciarrocchi, Esther, et al. “Performance Evaluation of the LightPath Imaging System for Intra-Operative Cerenkov Luminescence Imaging.” PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, vol. 52, 2018, pp. 122–28, doi:10.1016/j.ejmp.2018.07.005.
APA
Ciarrocchi, E., Vanhove, C., Descamps, B., De Lombaerde, S., Vandenberghe, S., & Belcari, N. (2018). Performance evaluation of the LightPath imaging system for intra-operative Cerenkov luminescence imaging. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 52, 122–128. https://doi.org/10.1016/j.ejmp.2018.07.005
Chicago author-date
Ciarrocchi, Esther, Christian Vanhove, Benedicte Descamps, Stef De Lombaerde, Stefaan Vandenberghe, and Nicola Belcari. 2018. “Performance Evaluation of the LightPath Imaging System for Intra-Operative Cerenkov Luminescence Imaging.” PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 52: 122–28. https://doi.org/10.1016/j.ejmp.2018.07.005.
Chicago author-date (all authors)
Ciarrocchi, Esther, Christian Vanhove, Benedicte Descamps, Stef De Lombaerde, Stefaan Vandenberghe, and Nicola Belcari. 2018. “Performance Evaluation of the LightPath Imaging System for Intra-Operative Cerenkov Luminescence Imaging.” PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 52: 122–128. doi:10.1016/j.ejmp.2018.07.005.
Vancouver
1.
Ciarrocchi E, Vanhove C, Descamps B, De Lombaerde S, Vandenberghe S, Belcari N. Performance evaluation of the LightPath imaging system for intra-operative Cerenkov luminescence imaging. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS. 2018;52:122–8.
IEEE
[1]
E. Ciarrocchi, C. Vanhove, B. Descamps, S. De Lombaerde, S. Vandenberghe, and N. Belcari, “Performance evaluation of the LightPath imaging system for intra-operative Cerenkov luminescence imaging,” PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, vol. 52, pp. 122–128, 2018.
@article{8570132,
  abstract     = {{The performances of an intra-operative optical imaging system for Cerenkov luminescence imaging of resected tumor specimens were evaluated with phantom studies. The spatial resolution, the linearity of the measured signal with the activity concentration and the minimum detectable activity concentration were considered. A high linearity was observed over a broad range of activity concentration (R-2 >= 0.99 down to similar to 40 kBq/ml of F-18-FDG). For F-18-FDG activity distributions 2 mm deep in biological tissue, the measured detection limit was 8 kBq/ml and a spatial resolution of 2.5 mm was obtained. The detection limit of the imaging system is comparable with clinical activity concentrations in tumor specimens, and the spatial resolution is compatible with clinical requirements.}},
  author       = {{Ciarrocchi, Esther and Vanhove, Christian and Descamps, Benedicte and De Lombaerde, Stef and Vandenberghe, Stefaan and Belcari, Nicola}},
  issn         = {{1120-1797}},
  journal      = {{PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS}},
  keywords     = {{Cerenkov luminescence imaging,Intra-operative imaging,Performance evaluation,Beta-emitting radiotracer,IN-VIVO,RADIOTRACERS,F-18-FDG}},
  language     = {{eng}},
  pages        = {{122--128}},
  title        = {{Performance evaluation of the LightPath imaging system for intra-operative Cerenkov luminescence imaging}},
  url          = {{http://doi.org/10.1016/j.ejmp.2018.07.005}},
  volume       = {{52}},
  year         = {{2018}},
}
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