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Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population : results from the population-based Rotterdam Study

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Abstract
Pulmonary hypertension is associated with increased mortality and morbidity in the elderly population. Heart failure is a common cause of pulmonary hypertension. Yet, the relation between left heart parameters reflective of subclinical cardiac dysfunction and increased filling pressures, and pulmonary arterial pressures in the elderly population remains elusive. Within the population-based Rotterdam Study, 2592 unselected participants with a mean age of 72.6 years (61.4% women) had complete echocardiography data available. We studied the cross-sectional associations of left heart structure and systolic and diastolic function with echocardiographically measured pulmonary artery systolic pressure. Mean pulmonary artery systolic pressure was 25.4 mmHg. After multivariable-adjustment measures of both structure and function were independently associated with pulmonary artery systolic pressure: E/A ratio [0.63 mmHg (95% CI 0.35-0.91) per 1-SD increase], left atrial diameter [0.79 mmHg (0.50-1.09) per 1-SD increase], E/E' ratio [1.27 mmHg (0.92-1.61) per 1-SD increase], left ventricular volume [0.62 mmHg (0.25-0.98) per 1-SD increase], fractional shortening [0.45 mmHg (0.17-0.74) per 1-SD increase], aortic root diameter [-0.43 mmHg (-0.72 to -0.14) per 1-SD increase], mitral valve deceleration time [-0.31 mmHg (-0.57 to -0.05) per 1-SD increase], and E' [1.04 mmHg (0.66-1.42) per 1-SD increase]. Results did not materially differ when restricting the analyses to participants free of symptoms of shortness of breath. Structural and functional echocardiographic parameters of subclinical cardiac dysfunction and increased filling pressures are associated with pulmonary arterial pressures in the unselected general ageing population.
Keywords
VENTRICULAR DIASTOLIC FUNCTION, ECHOCARDIOGRAPHIC-ASSESSMENT, DOPPLER-ECHOCARDIOGRAPHY, EUROPEAN ASSOCIATION, AMERICAN SOCIETY, RIGHT, HEART, HYPERTENSION, UPDATE, DETERMINANTS, GUIDELINES, Echocardiography, Pulmonary artery systolic pressure, Pulmonary, hypertension, Heart failure, Epidemiology, Population-based

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Chicago
Billar, Ryan J, Maarten JG Leening, Daphne Merkus, Guy Brusselle, Albert Hofman, Bruno Hch Stricker, H Ardeschir Ghofrani, Oscar H Franco, Henning Gall, and Janine F Felix. 2018. “Measures of Subclinical Cardiac Dysfunction and Increased Filling Pressures Associate with Pulmonary Arterial Pressure in the General Population : Results from the Population-based Rotterdam Study.” European Journal of Epidemiology 33 (4): 403–413.
APA
Billar, R. J., Leening, M. J., Merkus, D., Brusselle, G., Hofman, A., Stricker, B. Hc., Ghofrani, H. A., et al. (2018). Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population : results from the population-based Rotterdam Study. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 33(4), 403–413.
Vancouver
1.
Billar RJ, Leening MJ, Merkus D, Brusselle G, Hofman A, Stricker BHc, et al. Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population : results from the population-based Rotterdam Study. EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2018;33(4):403–13.
MLA
Billar, Ryan J et al. “Measures of Subclinical Cardiac Dysfunction and Increased Filling Pressures Associate with Pulmonary Arterial Pressure in the General Population : Results from the Population-based Rotterdam Study.” EUROPEAN JOURNAL OF EPIDEMIOLOGY 33.4 (2018): 403–413. Print.
@article{8570034,
  abstract     = {Pulmonary hypertension is associated with increased mortality and morbidity in the elderly population. Heart failure is a common cause of pulmonary hypertension. Yet, the relation between left heart parameters reflective of subclinical cardiac dysfunction and increased filling pressures, and pulmonary arterial pressures in the elderly population remains elusive. Within the population-based Rotterdam Study, 2592 unselected participants with a mean age of 72.6 years (61.4% women) had complete echocardiography data available. We studied the cross-sectional associations of left heart structure and systolic and diastolic function with echocardiographically measured pulmonary artery systolic pressure. Mean pulmonary artery systolic pressure was 25.4 mmHg. After multivariable-adjustment measures of both structure and function were independently associated with pulmonary artery systolic pressure: E/A ratio [0.63 mmHg (95% CI 0.35-0.91) per 1-SD increase], left atrial diameter [0.79 mmHg (0.50-1.09) per 1-SD increase], E/E' ratio [1.27 mmHg (0.92-1.61) per 1-SD increase], left ventricular volume [0.62 mmHg (0.25-0.98) per 1-SD increase], fractional shortening [0.45 mmHg (0.17-0.74) per 1-SD increase], aortic root diameter [-0.43 mmHg (-0.72 to -0.14) per 1-SD increase], mitral valve deceleration time [-0.31 mmHg (-0.57 to -0.05) per 1-SD increase], and E' [1.04 mmHg (0.66-1.42) per 1-SD increase]. Results did not materially differ when restricting the analyses to participants free of symptoms of shortness of breath. Structural and functional echocardiographic parameters of subclinical cardiac dysfunction and increased filling pressures are associated with pulmonary arterial pressures in the unselected general ageing population.},
  author       = {Billar, Ryan J and Leening, Maarten JG and Merkus, Daphne and Brusselle, Guy and Hofman, Albert and Stricker, Bruno HCh and Ghofrani, H Ardeschir and Franco, Oscar H and Gall, Henning and Felix, Janine F},
  issn         = {0393-2990},
  journal      = {EUROPEAN JOURNAL OF EPIDEMIOLOGY},
  keywords     = {VENTRICULAR DIASTOLIC FUNCTION,ECHOCARDIOGRAPHIC-ASSESSMENT,DOPPLER-ECHOCARDIOGRAPHY,EUROPEAN ASSOCIATION,AMERICAN SOCIETY,RIGHT,HEART,HYPERTENSION,UPDATE,DETERMINANTS,GUIDELINES,Echocardiography,Pulmonary artery systolic pressure,Pulmonary,hypertension,Heart failure,Epidemiology,Population-based},
  language     = {eng},
  number       = {4},
  pages        = {403--413},
  title        = {Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population : results from the population-based Rotterdam Study},
  url          = {http://dx.doi.org/10.1007/s10654-017-0341-0},
  volume       = {33},
  year         = {2018},
}

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