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Asthma and its comorbidities in middle-aged and older adults : the Rotterdam study

(2018) RESPIRATORY MEDICINE. 139. p.6-12
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Abstract
Background: Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort of adults 45 years of age and over. Methods: We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands. Pulmonary function measurements and comorbidities of the asthma cases were assessed at baseline and compared to those of the general population. Results: Out of 14,621 participants (mean age 65.5 years; 59% women), 524 subjects (31.5%males) had physician-diagnosed asthma at study entry, implicating an asthma prevalence of 3.6% [95% Confidence Interval (CI) 3.3%-3.9%] (2.8% in males and 4.2% in females). Asthmatic subjects had a significantly higher prevalence of obesity and depressive symptoms (Odds Ratio [OR]: 2,02 [95% CI 1,66-2,47] and [OR]: 2,01 [95% CI 1,52-2,66] respectively). Longer duration of asthma and current smoking were associated with lower lung function in asthmatic subjects. Conclusion: Four percent of middle-aged and older adults have physician-diagnosed asthma. These adult asthmatics suffer more frequently from obesity and depression than subjects without obstructive lung disease.
Keywords
OBSTRUCTIVE LUNG-DISEASE, ONSET ASTHMA, PREVALENCE, RISK, ASSOCIATION, MANAGEMENT, POPULATION, OBJECTIVES, DESIGN, UPDATE, Asthma, Older adults, Comorbidity, General population

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MLA
de Roos, Emmely, Lies Lahousse, Katia Verhamme, et al. “Asthma and Its Comorbidities in Middle-aged and Older Adults : the Rotterdam Study.” RESPIRATORY MEDICINE 139 (2018): 6–12. Print.
APA
de Roos, E., Lahousse, L., Verhamme, K., Braunstahl, G.-J., Ikram, M. A., in’t Veen, J. C., Stricker, B. Hc., et al. (2018). Asthma and its comorbidities in middle-aged and older adults : the Rotterdam study. RESPIRATORY MEDICINE, 139, 6–12.
Chicago author-date
de Roos, Emmely, Lies Lahousse, Katia Verhamme, Gert-Jan Braunstahl, M Arfan Ikram, Johannes CCM in’t Veen, Bruno Hch Stricker, and Guy Brusselle. 2018. “Asthma and Its Comorbidities in Middle-aged and Older Adults : the Rotterdam Study.” Respiratory Medicine 139: 6–12.
Chicago author-date (all authors)
de Roos, Emmely, Lies Lahousse, Katia Verhamme, Gert-Jan Braunstahl, M Arfan Ikram, Johannes CCM in’t Veen, Bruno Hch Stricker, and Guy Brusselle. 2018. “Asthma and Its Comorbidities in Middle-aged and Older Adults : the Rotterdam Study.” Respiratory Medicine 139: 6–12.
Vancouver
1.
de Roos E, Lahousse L, Verhamme K, Braunstahl G-J, Ikram MA, in’t Veen JC, et al. Asthma and its comorbidities in middle-aged and older adults : the Rotterdam study. RESPIRATORY MEDICINE. 2018;139:6–12.
IEEE
[1]
E. de Roos et al., “Asthma and its comorbidities in middle-aged and older adults : the Rotterdam study,” RESPIRATORY MEDICINE, vol. 139, pp. 6–12, 2018.
@article{8570020,
  abstract     = {Background: Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort of adults 45 years of age and over. 
Methods: We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands. Pulmonary function measurements and comorbidities of the asthma cases were assessed at baseline and compared to those of the general population. 
Results: Out of 14,621 participants (mean age 65.5 years; 59% women), 524 subjects (31.5%males) had physician-diagnosed asthma at study entry, implicating an asthma prevalence of 3.6% [95% Confidence Interval (CI) 3.3%-3.9%] (2.8% in males and 4.2% in females). Asthmatic subjects had a significantly higher prevalence of obesity and depressive symptoms (Odds Ratio [OR]: 2,02 [95% CI 1,66-2,47] and [OR]: 2,01 [95% CI 1,52-2,66] respectively). Longer duration of asthma and current smoking were associated with lower lung function in asthmatic subjects. 
Conclusion: Four percent of middle-aged and older adults have physician-diagnosed asthma. These adult asthmatics suffer more frequently from obesity and depression than subjects without obstructive lung disease.},
  author       = {de Roos, Emmely and Lahousse, Lies and Verhamme, Katia and Braunstahl, Gert-Jan and Ikram, M Arfan and in't Veen, Johannes CCM and Stricker, Bruno HCh and Brusselle, Guy},
  issn         = {0954-6111},
  journal      = {RESPIRATORY MEDICINE},
  keywords     = {OBSTRUCTIVE LUNG-DISEASE,ONSET ASTHMA,PREVALENCE,RISK,ASSOCIATION,MANAGEMENT,POPULATION,OBJECTIVES,DESIGN,UPDATE,Asthma,Older adults,Comorbidity,General population},
  language     = {eng},
  pages        = {6--12},
  title        = {Asthma and its comorbidities in middle-aged and older adults : the Rotterdam study},
  url          = {http://dx.doi.org/10.1016/j.rmed.2018.04.006},
  volume       = {139},
  year         = {2018},
}

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