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Insights in particulate matter-induced allergic airway inflammation : focus on the epithelium

Katrien De Grove (UGent) , Sharen Provoost (UGent) , Guy Brusselle (UGent) , Guy Joos (UGent) and Tania Maes (UGent)
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Abstract
Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. In this review, we focus on the role of the lung epithelium and specifically highlight multiple cytokines in PM-induced respiratory responses. We describe the available literature on the topic including invitro studies, findings in humans (ie observations in human cohorts, human controlled exposure and exvivo studies) and invivo animal studies. In brief, it has been shown that exposure to PM modulates the airway epithelium and promotes the production of several cytokines, including IL-1, IL-6, IL-8, IL-25, IL-33, TNF-, TSLP and GM-CSF. Further, we propose that PM-induced type 2-promoting cytokines are important mediators in the acute and aggravating effects of PM on airway inflammation. Targeting these cytokines could therefore be a new approach in the treatment of asthma.
Keywords
DIESEL EXHAUST PARTICLES, THYMIC STROMAL LYMPHOPOIETIN, NF-KAPPA-B, ASTHMATIC BRONCHIAL EPITHELIUM, CELLS IN-VITRO, NUCLEOTIDE-BINDING, DOMAIN, MURINE STRAIN DIFFERENCES, INNATE LYMPHOID-CELLS, SAN-JOAQUIN, VALLEY, S-TRANSFERASE M1, Asthma, Allergens, Air pollution, Particulate matter, Airway epithelium, Epithelial cytokines

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Chicago
De Grove, Katrien, Sharen Provoost, Guy Brusselle, Guy Joos, and Tania Maes. 2018. “Insights in Particulate Matter-induced Allergic Airway Inflammation : Focus on the Epithelium.” Clinical and Experimental Allergy 48 (7): 773–786.
APA
De Grove, K., Provoost, S., Brusselle, G., Joos, G., & Maes, T. (2018). Insights in particulate matter-induced allergic airway inflammation : focus on the epithelium. CLINICAL AND EXPERIMENTAL ALLERGY, 48(7), 773–786.
Vancouver
1.
De Grove K, Provoost S, Brusselle G, Joos G, Maes T. Insights in particulate matter-induced allergic airway inflammation : focus on the epithelium. CLINICAL AND EXPERIMENTAL ALLERGY. 2018;48(7):773–86.
MLA
De Grove, Katrien, Sharen Provoost, Guy Brusselle, et al. “Insights in Particulate Matter-induced Allergic Airway Inflammation : Focus on the Epithelium.” CLINICAL AND EXPERIMENTAL ALLERGY 48.7 (2018): 773–786. Print.
@article{8570015,
  abstract     = {Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. In this review, we focus on the role of the lung epithelium and specifically highlight multiple cytokines in PM-induced respiratory responses. We describe the available literature on the topic including invitro studies, findings in humans (ie observations in human cohorts, human controlled exposure and exvivo studies) and invivo animal studies. In brief, it has been shown that exposure to PM modulates the airway epithelium and promotes the production of several cytokines, including IL-1, IL-6, IL-8, IL-25, IL-33, TNF-, TSLP and GM-CSF. Further, we propose that PM-induced type 2-promoting cytokines are important mediators in the acute and aggravating effects of PM on airway inflammation. Targeting these cytokines could therefore be a new approach in the treatment of asthma.},
  author       = {De Grove, Katrien and Provoost, Sharen and Brusselle, Guy and Joos, Guy and Maes, Tania},
  issn         = {0954-7894},
  journal      = {CLINICAL AND EXPERIMENTAL ALLERGY},
  language     = {eng},
  number       = {7},
  pages        = {773--786},
  title        = {Insights in particulate matter-induced allergic airway inflammation : focus on the epithelium},
  url          = {http://dx.doi.org/10.1111/cea.13178},
  volume       = {48},
  year         = {2018},
}

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