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Impaired rich club and increased local connectivity in children with traumatic brain injury : local support for the rich?

(2018) HUMAN BRAIN MAPPING . 39(7). p.2800-2811
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Abstract
Recent evidence has shown the presence of a rich club in the brain, which constitutes a core network of highly interconnected and spatially distributed brain regions, important for high-order cognitive processes. This study aimed to map the rich club organization in 17 young patients with moderate to severe TBI (15.71 +/- 1.75 years) in the chronic stage of recovery and 17 age- and gender-matched controls. Probabilistic tractography was performed on diffusion weighted imaging data to construct the edges of the structural connectomes using number of streamlines as edge weight. In addition, the whole-brain network was divided into a rich club network, a local network and a feeder network connecting the latter two. Functional outcome was measured with a parent questionnaire for executive functioning. Our results revealed a significantly decreased rich club organization (p values<.05) and impaired executive functioning (p<.001) in young patients with TBI compared with controls. Specifically, we observed reduced density values in all three subnetworks (p values<.005) and a reduced mean strength in the rich club network (p=.013) together with an increased mean strength in the local network (p=.002) in patients with TBI. This study provides new insights into the nature of TBI-induced brain network alterations and supports the hypothesis that the local subnetwork tries to compensate for the biologically costly subnetwork of rich club nodes after TBI.
Keywords
diffusion-weighted imaging, graph theory, rich club, structural connectivity, traumatic brain injury, HUMAN CEREBRAL-CORTEX, STATE FUNCTIONAL CONNECTIVITY, STRUCTURAL CONNECTIVITY, DIFFUSION MRI, SPHERICAL-DECONVOLUTION, HUMAN CONNECTOME, SMALL-WORLD, ORGANIZATION, NETWORKS, IMAGES

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Chicago
Verhelst, Helena, Catharine Vander Linden, Toon De Pauw, Guy Vingerhoets, and Karen Caeyenberghs. 2018. “Impaired Rich Club and Increased Local Connectivity in Children with Traumatic Brain Injury : Local Support for the Rich?” Human Brain Mapping 39 (7): 2800–2811.
APA
Verhelst, H., Vander Linden, C., De Pauw, T., Vingerhoets, G., & Caeyenberghs, K. (2018). Impaired rich club and increased local connectivity in children with traumatic brain injury : local support for the rich? HUMAN BRAIN MAPPING , 39(7), 2800–2811.
Vancouver
1.
Verhelst H, Vander Linden C, De Pauw T, Vingerhoets G, Caeyenberghs K. Impaired rich club and increased local connectivity in children with traumatic brain injury : local support for the rich? HUMAN BRAIN MAPPING . 2018;39(7):2800–11.
MLA
Verhelst, Helena et al. “Impaired Rich Club and Increased Local Connectivity in Children with Traumatic Brain Injury : Local Support for the Rich?” HUMAN BRAIN MAPPING 39.7 (2018): 2800–2811. Print.
@article{8569987,
  abstract     = {Recent evidence has shown the presence of a rich club in the brain, which constitutes a core network of highly interconnected and spatially distributed brain regions, important for high-order cognitive processes. This study aimed to map the rich club organization in 17 young patients with moderate to severe TBI (15.71 +/- 1.75 years) in the chronic stage of recovery and 17 age- and gender-matched controls. Probabilistic tractography was performed on diffusion weighted imaging data to construct the edges of the structural connectomes using number of streamlines as edge weight. In addition, the whole-brain network was divided into a rich club network, a local network and a feeder network connecting the latter two. Functional outcome was measured with a parent questionnaire for executive functioning. Our results revealed a significantly decreased rich club organization (p values{\textlangle}.05) and impaired executive functioning (p{\textlangle}.001) in young patients with TBI compared with controls. Specifically, we observed reduced density values in all three subnetworks (p values{\textlangle}.005) and a reduced mean strength in the rich club network (p=.013) together with an increased mean strength in the local network (p=.002) in patients with TBI. This study provides new insights into the nature of TBI-induced brain network alterations and supports the hypothesis that the local subnetwork tries to compensate for the biologically costly subnetwork of rich club nodes after TBI.},
  author       = {Verhelst, Helena and Vander Linden, Catharine and De Pauw, Toon and Vingerhoets, Guy and Caeyenberghs, Karen},
  issn         = {1065-9471},
  journal      = {HUMAN BRAIN MAPPING },
  language     = {eng},
  number       = {7},
  pages        = {2800--2811},
  title        = {Impaired rich club and increased local connectivity in children with traumatic brain injury : local support for the rich?},
  url          = {http://dx.doi.org/10.1002/hbm.24041},
  volume       = {39},
  year         = {2018},
}

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