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Open surgery versus primary radiotherapy in T4b sinonasal carcinoma

Jens Debacker (UGent) , Wouter Huvenne (UGent) , Katrien Bonte (UGent) , Wilfried De Neve (UGent) , Philippe Deron (UGent) , Piet Ost (UGent) , Thibaut Van Zele (UGent) , Hubert Vermeersch (UGent) and Fréderic Duprez (UGent)
(2018) B-ENT. 14(2). p.93-99
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Organization
Abstract
Objectives: We evaluated the outcome after primary open surgery with adjuvant intensity modulated radiotherapy (IMRT) compared with primary IMRT in patients diagnosed with T4b sinonasal carcinoma. Methodology: Between 1998 and 2016, 20 patients with T4b sinonasal adenocarcinoma were treated with primary IMRT (n=10) with a high dose to achieve maximal locoregional control or adjuvant IMRT following open surgery (n=10). Results: With a median follow-up of 13.2 months, overall survival rates at 1 and 3 years were 55.0% and 15.2%. respectively; disease-specific survival rates were 47.8% and 23.9%. respectively; and disease-free survival rates were 45.0% and 22.5%, respectively. No significant differences were found between primary surgery and primary IMRT. Conclusions: Based on our limited, though homogeneous, patient cohort of cT4b sinonasal adenocarcinomas, we did not detect differences in outcome between primary surgery followed by adjuvant IMRT vs. primary IMRT. Thus, we have chosen to avoid open surgery, due to the bad prognosis and its invasiveness, by performing organ-sparing IMRT as the primary treatment for these patients.
Keywords
Intensity-modulated radiotherapy, paranasal sinus neoplasms, adenocarcinoma, head and neck cancer, QUALITY-OF-LIFE, TERM-FOLLOW-UP, NASAL CAVITY, ENDOSCOPIC RESECTION, PARANASAL SINUS, SKULL BASE, LEPTOMENINGEAL CARCINOMATOSIS, CRANIOFACIAL RESECTION, MALIGNANT-TUMORS, ADENOCARCINOMA

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Chicago
Debacker, Jens, Wouter Huvenne, Katrien Bonte, Wilfried De Neve, Philippe Deron, Piet Ost, Thibaut Van Zele, Hubert Vermeersch, and Fréderic Duprez. 2018. “Open Surgery Versus Primary Radiotherapy in T4b Sinonasal Carcinoma.” B-ent 14 (2): 93–99.
APA
Debacker, J., Huvenne, W., Bonte, K., De Neve, W., Deron, P., Ost, P., Van Zele, T., et al. (2018). Open surgery versus primary radiotherapy in T4b sinonasal carcinoma. B-ENT, 14(2), 93–99.
Vancouver
1.
Debacker J, Huvenne W, Bonte K, De Neve W, Deron P, Ost P, et al. Open surgery versus primary radiotherapy in T4b sinonasal carcinoma. B-ENT. 2018;14(2):93–9.
MLA
Debacker, Jens, Wouter Huvenne, Katrien Bonte, et al. “Open Surgery Versus Primary Radiotherapy in T4b Sinonasal Carcinoma.” B-ENT 14.2 (2018): 93–99. Print.
@article{8569196,
  abstract     = {Objectives: We evaluated the outcome after primary open surgery with adjuvant intensity modulated radiotherapy (IMRT) compared with primary IMRT in patients diagnosed with T4b sinonasal carcinoma. 
Methodology: Between 1998 and 2016, 20 patients with T4b sinonasal adenocarcinoma were treated with primary IMRT (n=10) with a high dose to achieve maximal locoregional control or adjuvant IMRT following open surgery (n=10). 
Results: With a median follow-up of 13.2 months, overall survival rates at 1 and 3 years were 55.0% and 15.2%. respectively; disease-specific survival rates were 47.8% and 23.9%. respectively; and disease-free survival rates were 45.0% and 22.5%, respectively. No significant differences were found between primary surgery and primary IMRT. 
Conclusions: Based on our limited, though homogeneous, patient cohort of cT4b sinonasal adenocarcinomas, we did not detect differences in outcome between primary surgery followed by adjuvant IMRT vs. primary IMRT. Thus, we have chosen to avoid open surgery, due to the bad prognosis and its invasiveness, by performing organ-sparing IMRT as the primary treatment for these patients.},
  author       = {Debacker, Jens and Huvenne, Wouter and Bonte, Katrien and De Neve, Wilfried and Deron, Philippe and Ost, Piet and Van Zele, Thibaut and Vermeersch, Hubert and Duprez, Fréderic},
  issn         = {1781-782X},
  journal      = {B-ENT},
  keywords     = {Intensity-modulated radiotherapy,paranasal sinus neoplasms,adenocarcinoma,head and neck cancer,QUALITY-OF-LIFE,TERM-FOLLOW-UP,NASAL CAVITY,ENDOSCOPIC RESECTION,PARANASAL SINUS,SKULL BASE,LEPTOMENINGEAL CARCINOMATOSIS,CRANIOFACIAL RESECTION,MALIGNANT-TUMORS,ADENOCARCINOMA},
  language     = {eng},
  number       = {2},
  pages        = {93--99},
  title        = {Open surgery versus primary radiotherapy in T4b sinonasal carcinoma},
  volume       = {14},
  year         = {2018},
}

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