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Brain structural and functional asymmetry in human situs inversus totalis

Guy Vingerhoets (UGent) , Xiang Li (UGent) , Lewis Hou, Stephanie Bogaert (UGent) , Helena Verhelst (UGent) , Robin Gerrits (UGent) , Roma Siugzdaite (UGent) and Neil Roberts
(2018) BRAIN STRUCTURE & FUNCTION. 223(4). p.1937-1952
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Abstract
Magnetic resonance imaging was used to investigate brain structural and functional asymmetries in 15 participants with complete visceral reversal (situs inversus totalis, SIT). Language-related brain structural and functional lateralization of SIT participants, including peri-Sylvian gray and white matter asymmetries and hemispheric language dominance, was similar to those of 15 control participants individually matched for sex, age, education, and handedness. In contrast, the SIT cohort showed reversal of the brain (Yakovlevian) torque (occipital petalia and occipital bending) compared to the control group. Secondary findings suggested different asymmetry patterns between SIT participants with (n = 6) or without (n = 9) primary ciliary dyskinesia (PCD, also known as Kartagener syndrome) although the small sample sizes warrant cautious interpretation. In particular, reversed brain torque was mainly due to the subgroup with PCD-unrelated SIT and this group also included 55% left handers, a ratio close to a random allocation of handedness. We conclude that complete visceral reversal has no effect on the lateralization of brain structural and functional asymmetries associated with language, but seems to reverse the typical direction of the brain torque in particular in participants that have SIT unrelated to PCD. The observed differences in asymmetry patterns of SIT groups with and without PCD seem to suggest that symmetry breaking of visceral laterality, brain torque, and language dominance rely on different mechanisms.
Keywords
Brain asymmetry, Situs inversus, Primary ciliary dyskinesia, Language dominance, Handedness, LANGUAGE LATERALIZATION, CEREBRAL LATERALIZATION, ARCUATE FASCICULUS, VERBAL FLUENCY, HANDEDNESS, SUBJECT, MRI, PATHWAYS, GENETICS, SPEECH

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MLA
Vingerhoets, Guy, et al. “Brain Structural and Functional Asymmetry in Human Situs Inversus Totalis.” BRAIN STRUCTURE & FUNCTION, vol. 223, no. 4, 2018, pp. 1937–52.
APA
Vingerhoets, G., Li, X., Hou, L., Bogaert, S., Verhelst, H., Gerrits, R., … Roberts, N. (2018). Brain structural and functional asymmetry in human situs inversus totalis. BRAIN STRUCTURE & FUNCTION, 223(4), 1937–1952.
Chicago author-date
Vingerhoets, Guy, Xiang Li, Lewis Hou, Stephanie Bogaert, Helena Verhelst, Robin Gerrits, Roma Siugzdaite, and Neil Roberts. 2018. “Brain Structural and Functional Asymmetry in Human Situs Inversus Totalis.” BRAIN STRUCTURE & FUNCTION 223 (4): 1937–52.
Chicago author-date (all authors)
Vingerhoets, Guy, Xiang Li, Lewis Hou, Stephanie Bogaert, Helena Verhelst, Robin Gerrits, Roma Siugzdaite, and Neil Roberts. 2018. “Brain Structural and Functional Asymmetry in Human Situs Inversus Totalis.” BRAIN STRUCTURE & FUNCTION 223 (4): 1937–1952.
Vancouver
1.
Vingerhoets G, Li X, Hou L, Bogaert S, Verhelst H, Gerrits R, et al. Brain structural and functional asymmetry in human situs inversus totalis. BRAIN STRUCTURE & FUNCTION. 2018;223(4):1937–52.
IEEE
[1]
G. Vingerhoets et al., “Brain structural and functional asymmetry in human situs inversus totalis,” BRAIN STRUCTURE & FUNCTION, vol. 223, no. 4, pp. 1937–1952, 2018.
@article{8568939,
  abstract     = {Magnetic resonance imaging was used to investigate brain structural and functional asymmetries in 15 participants with complete visceral reversal (situs inversus totalis, SIT). Language-related brain structural and functional lateralization of SIT participants, including peri-Sylvian gray and white matter asymmetries and hemispheric language dominance, was similar to those of 15 control participants individually matched for sex, age, education, and handedness. In contrast, the SIT cohort showed reversal of the brain (Yakovlevian) torque (occipital petalia and occipital bending) compared to the control group. Secondary findings suggested different asymmetry patterns between SIT participants with (n = 6) or without (n = 9) primary ciliary dyskinesia (PCD, also known as Kartagener syndrome) although the small sample sizes warrant cautious interpretation. In particular, reversed brain torque was mainly due to the subgroup with PCD-unrelated SIT and this group also included 55% left handers, a ratio close to a random allocation of handedness. We conclude that complete visceral reversal has no effect on the lateralization of brain structural and functional asymmetries associated with language, but seems to reverse the typical direction of the brain torque in particular in participants that have SIT unrelated to PCD. The observed differences in asymmetry patterns of SIT groups with and without PCD seem to suggest that symmetry breaking of visceral laterality, brain torque, and language dominance rely on different mechanisms.},
  author       = {Vingerhoets, Guy and Li, Xiang and Hou, Lewis and Bogaert, Stephanie and Verhelst, Helena and Gerrits, Robin and Siugzdaite, Roma and Roberts, Neil},
  issn         = {1863-2653},
  journal      = {BRAIN STRUCTURE & FUNCTION},
  keywords     = {Brain asymmetry,Situs inversus,Primary ciliary dyskinesia,Language dominance,Handedness,LANGUAGE LATERALIZATION,CEREBRAL LATERALIZATION,ARCUATE FASCICULUS,VERBAL FLUENCY,HANDEDNESS,SUBJECT,MRI,PATHWAYS,GENETICS,SPEECH},
  language     = {eng},
  number       = {4},
  pages        = {1937--1952},
  title        = {Brain structural and functional asymmetry in human situs inversus totalis},
  url          = {http://dx.doi.org/10.1007/s00429-017-1598-5},
  volume       = {223},
  year         = {2018},
}

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