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Effects of radiation on the metastatic process

Nora Sundahl (UGent) , Fréderic Duprez (UGent) , Piet Ost (UGent) , Wilfried De Neve (UGent) and Marcus Mareel (UGent)
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Abstract
Radiotherapy remains one of the corner stones in the treatment of various malignancies and often leads to an improvement in overall survival. Nonetheless, pre-clinical evidence indicates that radiation can entail pro-metastatic effects via multiple pathways. Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. However, the data remains ambiguous and clinical observations that unequivocally prove these findings are lacking. In this review we discuss the pre-clinical and clinical data on the local and systemic effect of irradiation on the metastatic process with an emphasis on the molecular pathways involved.
Keywords
EPITHELIAL-MESENCHYMAL TRANSITION, CELL LUNG-CANCER, CARBON-ION, IRRADIATION, GROWTH-FACTOR RECEPTOR, MATRIX-METALLOPROTEINASE INHIBITOR, WNT/BETA-CATENIN PATHWAY, RHO SIGNALING PATHWAY, INDUCED UP-REGULATION, EMT-LIKE PHENOTYPE, NF-KAPPA-B, Radiation, Radiotherapy, Invasion, Metastasis, Cancer

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Citation

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Chicago
Sundahl, Nora, Fréderic Duprez, Piet Ost, Wilfried De Neve, and Marcus Mareel. 2018. “Effects of Radiation on the Metastatic Process.” Molecular Medicine 24.
APA
Sundahl, N., Duprez, F., Ost, P., De Neve, W., & Mareel, M. (2018). Effects of radiation on the metastatic process. MOLECULAR MEDICINE, 24.
Vancouver
1.
Sundahl N, Duprez F, Ost P, De Neve W, Mareel M. Effects of radiation on the metastatic process. MOLECULAR MEDICINE. 2018;24.
MLA
Sundahl, Nora, Fréderic Duprez, Piet Ost, et al. “Effects of Radiation on the Metastatic Process.” MOLECULAR MEDICINE 24 (2018): n. pag. Print.
@article{8568329,
  abstract     = {Radiotherapy remains one of the corner stones in the treatment of various malignancies and often leads to an improvement in overall survival. Nonetheless, pre-clinical evidence indicates that radiation can entail pro-metastatic effects via multiple pathways. Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. However, the data remains ambiguous and clinical observations that unequivocally prove these findings are lacking. In this review we discuss the pre-clinical and clinical data on the local and systemic effect of irradiation on the metastatic process with an emphasis on the molecular pathways involved.},
  articleno    = {16},
  author       = {Sundahl, Nora and Duprez, Fréderic and Ost, Piet and De Neve, Wilfried and Mareel, Marcus},
  issn         = {1076-1551},
  journal      = {MOLECULAR MEDICINE},
  keywords     = {EPITHELIAL-MESENCHYMAL TRANSITION,CELL LUNG-CANCER,CARBON-ION,IRRADIATION,GROWTH-FACTOR RECEPTOR,MATRIX-METALLOPROTEINASE INHIBITOR,WNT/BETA-CATENIN PATHWAY,RHO SIGNALING PATHWAY,INDUCED UP-REGULATION,EMT-LIKE PHENOTYPE,NF-KAPPA-B,Radiation,Radiotherapy,Invasion,Metastasis,Cancer},
  language     = {eng},
  pages        = {20},
  title        = {Effects of radiation on the metastatic process},
  url          = {http://dx.doi.org/10.1186/s10020-018-0015-8},
  volume       = {24},
  year         = {2018},
}

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