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Pharmacological strategies for manipulating plant Ca2+ signalling

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Abstract
Calcium is one of the most pleiotropic second messengers in all living organisms. However, signalling specificity is encoded via spatio-temporally regulated signatures that act with surgical precision to elicit highly specific cellular responses. How this is brought about remains a big challenge in the plant field, in part due to a lack of specific tools to manipulate/interrogate the plant Ca2+ toolkit. In many cases, researchers resort to tools that were optimized in animal cells. However, the obviously large evolutionary distance between plants and animals implies that there is a good chance observed effects may not be specific to the intended plant target. Here, we provide an overview of pharmacological strategies that are commonly used to activate or inhibit plant Ca2+ signalling. We focus on highlighting modes of action where possible, and warn for potential pitfalls. Together, this review aims at guiding plant researchers through the Ca2+ pharmacology swamp.
Keywords
DEPENDENT PROTEIN-KINASE, PLASMA-MEMBRANE CA2+-ATPASE, CALMODULIN-BINDING PROTEINS, ACTIVATED CALCIUM-CHANNELS, ARABIDOPSIS, GUARD-CELLS, RECEPTOR-LIKE GENE, CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE, THALIANA CULTURED-CELLS, LILY POLLEN TUBES, RUTHENIUM RED, calcium, Ca2+ channel, Ca2+ ATPase, calmodulin, Ca2+ chelator, Ca2+, ionophore

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  • De Vriese et al. (2018) International Journal of Molecular Sciences 19,1506.pdf
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Chicago
De Vriese, Kjell, Alexandra Costantini, Tom Beeckman, and Steffen Vanneste. 2018. “Pharmacological Strategies for Manipulating Plant Ca2+ Signalling.” International Journal of Molecular Sciences 19 (5).
APA
De Vriese, K., Costantini, A., Beeckman, T., & Vanneste, S. (2018). Pharmacological strategies for manipulating plant Ca2+ signalling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(5).
Vancouver
1.
De Vriese K, Costantini A, Beeckman T, Vanneste S. Pharmacological strategies for manipulating plant Ca2+ signalling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(5).
MLA
De Vriese, Kjell et al. “Pharmacological Strategies for Manipulating Plant Ca2+ Signalling.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.5 (2018): n. pag. Print.
@article{8567926,
  abstract     = {Calcium is one of the most pleiotropic second messengers in all living organisms. However, signalling specificity is encoded via spatio-temporally regulated signatures that act with surgical precision to elicit highly specific cellular responses. How this is brought about remains a big challenge in the plant field, in part due to a lack of specific tools to manipulate/interrogate the plant Ca2+ toolkit. In many cases, researchers resort to tools that were optimized in animal cells. However, the obviously large evolutionary distance between plants and animals implies that there is a good chance observed effects may not be specific to the intended plant target. Here, we provide an overview of pharmacological strategies that are commonly used to activate or inhibit plant Ca2+ signalling. We focus on highlighting modes of action where possible, and warn for potential pitfalls. Together, this review aims at guiding plant researchers through the Ca2+ pharmacology swamp.},
  articleno    = {1506},
  author       = {De Vriese, Kjell and Costantini, Alexandra and Beeckman, Tom and Vanneste, Steffen},
  issn         = {1422-0067},
  journal      = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
  keywords     = {DEPENDENT PROTEIN-KINASE,PLASMA-MEMBRANE CA2+-ATPASE,CALMODULIN-BINDING PROTEINS,ACTIVATED CALCIUM-CHANNELS,ARABIDOPSIS,GUARD-CELLS,RECEPTOR-LIKE GENE,CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE,THALIANA CULTURED-CELLS,LILY POLLEN TUBES,RUTHENIUM RED,calcium,Ca2+ channel,Ca2+ ATPase,calmodulin,Ca2+ chelator,Ca2+,ionophore},
  language     = {eng},
  number       = {5},
  pages        = {26},
  title        = {Pharmacological strategies for manipulating plant Ca2+ signalling},
  url          = {http://dx.doi.org/10.3390/ijms19051506},
  volume       = {19},
  year         = {2018},
}

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