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Regional alterations of cerebral [18F]FDG metabolism in the chronic unpredictable mild stress- and the repeated corticosterone depression model in rats

Nick Van Laeken (UGent) , Glenn Pauwelyn (UGent) , Robrecht Dockx (UGent) , Benedicte Descamps (UGent) , Boudewijn Brans (UGent) , Kathelijne Peremans (UGent) , Chris Baeken (UGent) , Ingeborg Goethals (UGent) , Christian Vanhove (UGent) and Filip De Vos (UGent)
(2018) JOURNAL OF NEURAL TRANSMISSION. 125(9). p.1381-1393
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Abstract
Preclinical research has been indispensable in the exploration of the neurological basis of major depressive disorder (MDD). The present study aimed to examine effects on regional brain activity of two frequently used depression models, the chronic unpredictable mild stress (CUMS)- and the chronic corticosterone (CORT) depression model. The CUMS and CORT depression model were induced by exposing male Long-Evans rats to a 4-week procedure of unpredictable mild stressors or a 3-week procedure of chronic corticosterone, respectively. Positron emission tomography with [F-18]FDG was performed to determine alterations in regional brain activity. In addition, depressive- and anxiety-like behaviour was assessed via the forced swim test and the open field test, respectively. The chronic CORT administration, but not the CUMS model, significantly induced depressive-like behaviour and elevated plasma corticosterone levels. Compared to control, induction of the CORT depression model resulted in a significantly reduced glucose consumption in the insular cortex and the striatum, and a significantly elevated consumption in the cerebellum and the midbrain. Induction of the CUMS model replicated the findings with respect to the activity in the striatum region, and cerebellum, but missed significance in the insular cortex and the midbrain. Based on the alterations in behaviour and regional [F-18]FDG uptake, a superior face validity and construct validity can be observed after induction of depression via chronic CORT injections, compared to the used CUMS paradigm.
Keywords
[F-18]FDG, Corticosterone, Chronic unpredictable mild stress, Cerebral glucose metabolism, Depression, Long-Evans rats, MAJOR DEPRESSION, ANIMAL-MODELS, GLUCOSE-METABOLISM, RODENT MODEL, BEHAVIOR, BRAIN, AMYGDALA, INVOLVEMENT, PATHOPHYSIOLOGY, EXPRESSION

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Chicago
Van Laeken, Nick, Glenn Pauwelyn, Robrecht Dockx, Benedicte Descamps, Boudewijn Brans, Kathelijne Peremans, Chris Baeken, Ingeborg Goethals, Christian Vanhove, and Filip De Vos. 2018. “Regional Alterations of Cerebral [18F]FDG Metabolism in the Chronic Unpredictable Mild Stress- and the Repeated Corticosterone Depression Model in Rats.” Journal of Neural Transmission 125 (9): 1381–1393.
APA
Van Laeken, N., Pauwelyn, G., Dockx, R., Descamps, B., Brans, B., Peremans, K., Baeken, C., et al. (2018). Regional alterations of cerebral [18F]FDG metabolism in the chronic unpredictable mild stress- and the repeated corticosterone depression model in rats. JOURNAL OF NEURAL TRANSMISSION, 125(9), 1381–1393.
Vancouver
1.
Van Laeken N, Pauwelyn G, Dockx R, Descamps B, Brans B, Peremans K, et al. Regional alterations of cerebral [18F]FDG metabolism in the chronic unpredictable mild stress- and the repeated corticosterone depression model in rats. JOURNAL OF NEURAL TRANSMISSION. 2018;125(9):1381–93.
MLA
Van Laeken, Nick, Glenn Pauwelyn, Robrecht Dockx, et al. “Regional Alterations of Cerebral [18F]FDG Metabolism in the Chronic Unpredictable Mild Stress- and the Repeated Corticosterone Depression Model in Rats.” JOURNAL OF NEURAL TRANSMISSION 125.9 (2018): 1381–1393. Print.
@article{8567704,
  abstract     = {Preclinical research has been indispensable in the exploration of the neurological basis of major depressive disorder (MDD). The present study aimed to examine effects on regional brain activity of two frequently used depression models, the chronic unpredictable mild stress (CUMS)- and the chronic corticosterone (CORT) depression model. The CUMS and CORT depression model were induced by exposing male Long-Evans rats to a 4-week procedure of unpredictable mild stressors or a 3-week procedure of chronic corticosterone, respectively. Positron emission tomography with [F-18]FDG was performed to determine alterations in regional brain activity. In addition, depressive- and anxiety-like behaviour was assessed via the forced swim test and the open field test, respectively. The chronic CORT administration, but not the CUMS model, significantly induced depressive-like behaviour and elevated plasma corticosterone levels. Compared to control, induction of the CORT depression model resulted in a significantly reduced glucose consumption in the insular cortex and the striatum, and a significantly elevated consumption in the cerebellum and the midbrain. Induction of the CUMS model replicated the findings with respect to the activity in the striatum region, and cerebellum, but missed significance in the insular cortex and the midbrain. Based on the alterations in behaviour and regional [F-18]FDG uptake, a superior face validity and construct validity can be observed after induction of depression via chronic CORT injections, compared to the used CUMS paradigm.},
  author       = {Van Laeken, Nick and Pauwelyn, Glenn and Dockx, Robrecht and Descamps, Benedicte and Brans, Boudewijn and Peremans, Kathelijne and Baeken, Chris and Goethals, Ingeborg and Vanhove, Christian and De Vos, Filip},
  issn         = {0300-9564},
  journal      = {JOURNAL OF NEURAL TRANSMISSION},
  keyword      = {[F-18]FDG,Corticosterone,Chronic unpredictable mild stress,Cerebral glucose metabolism,Depression,Long-Evans rats,MAJOR DEPRESSION,ANIMAL-MODELS,GLUCOSE-METABOLISM,RODENT MODEL,BEHAVIOR,BRAIN,AMYGDALA,INVOLVEMENT,PATHOPHYSIOLOGY,EXPRESSION},
  language     = {eng},
  number       = {9},
  pages        = {1381--1393},
  title        = {Regional alterations of cerebral [18F]FDG metabolism in the chronic unpredictable mild stress- and the repeated corticosterone depression model in rats},
  url          = {http://dx.doi.org/10.1007/s00702-018-1899-8},
  volume       = {125},
  year         = {2018},
}

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