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Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes : in search of the culprit allergen

(2018) CONTACT DERMATITIS. 78(1). p.7-11
Author
Organization
Abstract
Background. During rubber vulcanization, new compounds can be formed. Objectives. To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). Methods. A female presented with eczema on her feet after wearing Sperry Top Sider (R) canvas sneakers. Patch testing was performed with the European baseline series, additional series, shoe materials, and extracts of shoe materials. Thin-layer chromatography (TLC) was performed for additional patch testing, and high-performance liquid chromatography and gas chromatography-mass spectometry were used for chemical analysis. Results. Positive reactions were found to thiuram mix (+), tetramethylthiuram monosulfide (TMTM) (+), shoe material (+), and shoe extracts in eth. (++) and acetone (+). The extracts did not contain TMTM or other components of thiuram mix. TLC strips yielded a positive reaction (+) to one spot, whereas chemical analysis gave a negative result. Thereafter, a similar sneaker from another patient with shoe dermatitis was analysed, and DMBTS was identified. New extracts of the shoe of our first patient were then also shown to contain DMTBS. DMTBS as culprit allergen was confirmed by positive patch testing with a dilution series with DMTBS. Conclusion. DMBTS was identified as the culprit allergen in shoe dermatitis, giving rise to compound allergy. The positive reaction to TMTM was considered to represent cross-reactivity.
Keywords
allergic contact dermatitis, CAS no. 3432-25-5, case report, dimethylthiocarbamylbenzothiazole sulfide, DMTBS, gas chromatography–massspectrometry, shoe dermatitis, thin-layer chromatography, thiurams, ultrasonic bathextract., VULCANIZATION, RUBBER

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Citation

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MLA
Schuttelaar, Marie L et al. “Allergic Contact Dermatitis Caused by Dimethylthiocarbamylbenzothiazole Sulfide (DMTBS) in Canvas Shoes : in Search of the Culprit Allergen.” CONTACT DERMATITIS 78.1 (2018): 7–11. Print.
APA
Schuttelaar, M. L., Meijer, J. M., Engfeldt, M., Lapeere, H., Goossens, A., Bruze, M., Persson, C., et al. (2018). Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes : in search of the culprit allergen. CONTACT DERMATITIS, 78(1), 7–11.
Chicago author-date
Schuttelaar, Marie L, Joost M Meijer, Malin Engfeldt, Hilde Lapeere, An Goossens, Magnus Bruze, Christina Persson, and Ola Bergendorff. 2018. “Allergic Contact Dermatitis Caused by Dimethylthiocarbamylbenzothiazole Sulfide (DMTBS) in Canvas Shoes : in Search of the Culprit Allergen.” Contact Dermatitis 78 (1): 7–11.
Chicago author-date (all authors)
Schuttelaar, Marie L, Joost M Meijer, Malin Engfeldt, Hilde Lapeere, An Goossens, Magnus Bruze, Christina Persson, and Ola Bergendorff. 2018. “Allergic Contact Dermatitis Caused by Dimethylthiocarbamylbenzothiazole Sulfide (DMTBS) in Canvas Shoes : in Search of the Culprit Allergen.” Contact Dermatitis 78 (1): 7–11.
Vancouver
1.
Schuttelaar ML, Meijer JM, Engfeldt M, Lapeere H, Goossens A, Bruze M, et al. Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes : in search of the culprit allergen. CONTACT DERMATITIS. 2018;78(1):7–11.
IEEE
[1]
M. L. Schuttelaar et al., “Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes : in search of the culprit allergen,” CONTACT DERMATITIS, vol. 78, no. 1, pp. 7–11, 2018.
@article{8566904,
  abstract     = {Background. During rubber vulcanization, new compounds can be formed. 
Objectives. To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). 
Methods. A female presented with eczema on her feet after wearing Sperry Top Sider (R) canvas sneakers. Patch testing was performed with the European baseline series, additional series, shoe materials, and extracts of shoe materials. Thin-layer chromatography (TLC) was performed for additional patch testing, and high-performance liquid chromatography and gas chromatography-mass spectometry were used for chemical analysis. 
Results. Positive reactions were found to thiuram mix (+), tetramethylthiuram monosulfide (TMTM) (+), shoe material (+), and shoe extracts in eth. (++) and acetone (+). The extracts did not contain TMTM or other components of thiuram mix. TLC strips yielded a positive reaction (+) to one spot, whereas chemical analysis gave a negative result. Thereafter, a similar sneaker from another patient with shoe dermatitis was analysed, and DMBTS was identified. New extracts of the shoe of our first patient were then also shown to contain DMTBS. DMTBS as culprit allergen was confirmed by positive patch testing with a dilution series with DMTBS. 
Conclusion. DMBTS was identified as the culprit allergen in shoe dermatitis, giving rise to compound allergy. The positive reaction to TMTM was considered to represent cross-reactivity.},
  author       = {Schuttelaar, Marie L and Meijer, Joost M and Engfeldt, Malin and Lapeere, Hilde and Goossens, An and Bruze, Magnus and Persson, Christina and Bergendorff, Ola},
  issn         = {0105-1873},
  journal      = {CONTACT DERMATITIS},
  keywords     = {allergic contact dermatitis,CAS no. 3432-25-5,case report,dimethylthiocarbamylbenzothiazole sulfide,DMTBS,gas chromatography–massspectrometry,shoe dermatitis,thin-layer chromatography,thiurams,ultrasonic bathextract.,VULCANIZATION,RUBBER},
  language     = {eng},
  number       = {1},
  pages        = {7--11},
  title        = {Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes : in search of the culprit allergen},
  url          = {http://dx.doi.org/10.1111/cod.12857},
  volume       = {78},
  year         = {2018},
}

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