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Synaptogyrin-3 mediates presynaptic dysfunction induced by Tau

Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert (UGent) , Ilse Dewachter, Tara L Spires-Jones, et al.
(2018) NEURON. 97(4). p.823-835
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Abstract
Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may be therapeutically beneficial to prevent cognitive decline and disease progression, but the mechanisms underlying synaptic defects associated with Tau are unclear. In disease conditions, Tau mislocalizes into pre- and postsynaptic compartments; here we show that, under pathological conditions, Tau binds to presynaptic vesicles in Alzheimer's disease patient brain. We define that the binding of Tau to synaptic vesicles is mediated by the transmembrane vesicle protein Synaptogyrin-3. In fly and mouse models of Tauopathy, reduction of Synaptogyrin-3 prevents the association of presynaptic Tau with vesicles, alleviates Tau-induced defects in vesicle mobility, and restores neurotransmitter release. This work therefore identifies Synaptogyrin-3 as the binding partner of Tau on synaptic vesicles, revealing a new presynapse-specific Tau interactor, which may contribute to early synaptic dysfunction in neurodegenerative diseases associated with Tau.
Keywords
EARLY ALZHEIMERS-DISEASE, CENTRAL-NERVOUS-SYSTEM, TAUOPATHY MOUSE MODEL, SYNAPTIC VESICLES, AMYLOID-BETA, EXTRACELLULAR VESICLES, PROTEIN INTERACTIONS, MEMORY FUNCTION, MAPT HAPLOTYPE, PATHOLOGY

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MLA
McInnes, Joseph et al. “Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.” NEURON 97.4 (2018): 823–835. Print.
APA
McInnes, J., Wierda, K., Snellinx, A., Bounti, L., Wang, Y.-C., Stancu, I.-C., Apóstolo, N., et al. (2018). Synaptogyrin-3 mediates presynaptic dysfunction induced by Tau. NEURON, 97(4), 823–835.
Chicago author-date
McInnes, Joseph, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, et al. 2018. “Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.” Neuron 97 (4): 823–835.
Chicago author-date (all authors)
McInnes, Joseph, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, and Patrik Verstreken. 2018. “Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.” Neuron 97 (4): 823–835.
Vancouver
1.
McInnes J, Wierda K, Snellinx A, Bounti L, Wang Y-C, Stancu I-C, et al. Synaptogyrin-3 mediates presynaptic dysfunction induced by Tau. NEURON. 2018;97(4):823–35.
IEEE
[1]
J. McInnes et al., “Synaptogyrin-3 mediates presynaptic dysfunction induced by Tau,” NEURON, vol. 97, no. 4, pp. 823–835, 2018.
@article{8566719,
  abstract     = {Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may be therapeutically beneficial to prevent cognitive decline and disease progression, but the mechanisms underlying synaptic defects associated with Tau are unclear. In disease conditions, Tau mislocalizes into pre- and postsynaptic compartments; here we show that, under pathological conditions, Tau binds to presynaptic vesicles in Alzheimer's disease patient brain. We define that the binding of Tau to synaptic vesicles is mediated by the transmembrane vesicle protein Synaptogyrin-3. In fly and mouse models of Tauopathy, reduction of Synaptogyrin-3 prevents the association of presynaptic Tau with vesicles, alleviates Tau-induced defects in vesicle mobility, and restores neurotransmitter release. This work therefore identifies Synaptogyrin-3 as the binding partner of Tau on synaptic vesicles, revealing a new presynapse-specific Tau interactor, which may contribute to early synaptic dysfunction in neurodegenerative diseases associated with Tau.},
  author       = {McInnes, Joseph and Wierda, Keimpe and Snellinx, An and Bounti, Laura and Wang, Yu-Chun and Stancu, Ilie-Cosmin and Apóstolo, Nuno and Gevaert, Kris and Dewachter, Ilse and Spires-Jones, Tara L and De Strooper, Bart and De Wit, Joris and Zhou, Lujia and Verstreken, Patrik},
  issn         = {0896-6273},
  journal      = {NEURON},
  keywords     = {EARLY ALZHEIMERS-DISEASE,CENTRAL-NERVOUS-SYSTEM,TAUOPATHY MOUSE MODEL,SYNAPTIC VESICLES,AMYLOID-BETA,EXTRACELLULAR VESICLES,PROTEIN INTERACTIONS,MEMORY FUNCTION,MAPT HAPLOTYPE,PATHOLOGY},
  language     = {eng},
  number       = {4},
  pages        = {823--835},
  title        = {Synaptogyrin-3 mediates presynaptic dysfunction induced by Tau},
  url          = {http://dx.doi.org/10.1016/j.neuron.2018.01.022},
  volume       = {97},
  year         = {2018},
}
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