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Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens

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Abstract
Intestinal health is critically important for the welfare and performance of poultry. Enteric diseases that cause gut barrier failure result in high economic losses. Up till now there is no reliable faecal marker to measure gut barrier failure under field conditions. Therefore, the aim of the present study was to identify a faecal protein marker for diminished intestinal barrier function due to enteric diseases in broilers. To assess this, experimental necrotic enteritis and coccidiosis in broilers were used as models for gut barrier failure. Ovotransferrin was identified as a marker for gut barrier failure using a proteomics approach on samples from chickens with necrotic enteritis. These results were confirmed via ELISA on samples derived from both necrotic enteritis and coccidiosis trials, where faecal ovotransferrin levels were significantly correlated with the severity of gut barrier failure caused by either coccidiosis or necrotic enteritis. This indicates that faecal ovotransferrin quantification may represent a valuable tool to measure gut barrier failure caused by enteric pathogens.
Keywords
ACUTE-PHASE PROTEINS, NECROTIC ENTERITIS, INFLAMMATION, COCCIDIOSIS, PROTEOMICS, INHIBITOR, DISEASES, MODEL

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Citation

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Chicago
Goossens, Evy, Griet Debyser, Chana Callens, Maarten De Gussem, Annelike Dedeurwaerder, Bart Devreese, Freddy Haesebrouck, et al. 2018. “Elevated Faecal Ovotransferrin Concentrations Are Indicative for Intestinal Barrier Failure in Broiler Chickens.” Veterinary Research 49.
APA
Goossens, Evy, Debyser, G., Callens, C., De Gussem, M., Dedeurwaerder, A., Devreese, B., Haesebrouck, F., et al. (2018). Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens. VETERINARY RESEARCH, 49.
Vancouver
1.
Goossens E, Debyser G, Callens C, De Gussem M, Dedeurwaerder A, Devreese B, et al. Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens. VETERINARY RESEARCH. 2018;49.
MLA
Goossens, Evy, Griet Debyser, Chana Callens, et al. “Elevated Faecal Ovotransferrin Concentrations Are Indicative for Intestinal Barrier Failure in Broiler Chickens.” VETERINARY RESEARCH 49 (2018): n. pag. Print.
@article{8566526,
  abstract     = {Intestinal health is critically important for the welfare and performance of poultry. Enteric diseases that cause gut barrier failure result in high economic losses. Up till now there is no reliable faecal marker to measure gut barrier failure under field conditions. Therefore, the aim of the present study was to identify a faecal protein marker for diminished intestinal barrier function due to enteric diseases in broilers. To assess this, experimental necrotic enteritis and coccidiosis in broilers were used as models for gut barrier failure. Ovotransferrin was identified as a marker for gut barrier failure using a proteomics approach on samples from chickens with necrotic enteritis. These results were confirmed via ELISA on samples derived from both necrotic enteritis and coccidiosis trials, where faecal ovotransferrin levels were significantly correlated with the severity of gut barrier failure caused by either coccidiosis or necrotic enteritis. This indicates that faecal ovotransferrin quantification may represent a valuable tool to measure gut barrier failure caused by enteric pathogens.},
  articleno    = {51},
  author       = {Goossens, Evy and Debyser, Griet and Callens, Chana and De Gussem, Maarten and Dedeurwaerder, Annelike and Devreese, Bart and Haesebrouck, Freddy and Fl{\"u}gel, Monika and Pelzer, Stefan and Thiemann, Frank and Ducatelle, Richard and Van Immerseel, Filip},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  language     = {eng},
  pages        = {8},
  title        = {Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens},
  url          = {http://dx.doi.org/10.1186/s13567-018-0548-4},
  volume       = {49},
  year         = {2018},
}

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