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Reduced distractor interference during vagus nerve stimulation

Marlies van Bochove (UGent) , Leen De Taeye (UGent) , Robrecht Raedt (UGent) , Kristl Vonck (UGent) , Alfred Meurs (UGent) , Paul Boon (UGent) , Ine Dauwe (UGent) , Wim Notebaert (UGent) and Tom Verguts (UGent)
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Abstract
Suppressing irrelevant information in decision making is an essential everyday skill. We studied whether this ability could be improved in epileptic patients during vagus nerve stimulation (VNS). VNS is known to increase norepinephrine (NE) in the brain. NE is thought to improve several aspects of cognitive control, including the suppression of irrelevant information. Nineteen epileptic VNS patients executed the Eriksen flanker task twice, both during on and off stimulation. Distractor interference was indexed by the congruency effect, a standard empirical marker of cognitive control. We found a reduced congruency effect during stimulation, which indicates an improved ability to suppress distractor interference. This effect was only found in patients that are clinically determined VNS-responders (n = 10). As VNS increases NE in VNS-responders, our finding suggests a beneficial role of NE in cognitive control. At the same time, it suggests that VNS does not only reduce seizure frequency in epileptic patients, but also improves cognitive control.
Keywords
THERAPY-RESISTANT EPILEPSY, LOCUS-COERULEUS LESIONS, COGNITIVE CONTROL, REFRACTORY EPILEPSY, PREFRONTAL CORTEX, NORADRENERGIC MODULATION, INDIVIDUAL-DIFFERENCES, ALZHEIMERS-DISEASE, ANTERIOR CINGULATE, HUMAN, NEOCORTEX, Cognitive control, Congruency effect, Vagus nerve stimulation (VNS), Norepinephrine (NE), Epilepsy

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Chicago
van Bochove, Marlies, Leen De Taeye, Robrecht Raedt, Kristl Vonck, Alfred Meurs, Paul Boon, Ine Dauwe, Wim Notebaert, and Tom Verguts. 2018. “Reduced Distractor Interference During Vagus Nerve Stimulation.” International Journal of Psychophysiology 128: 93–99.
APA
van Bochove, M., De Taeye, L., Raedt, R., Vonck, K., Meurs, A., Boon, P., Dauwe, I., et al. (2018). Reduced distractor interference during vagus nerve stimulation. INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 128, 93–99.
Vancouver
1.
van Bochove M, De Taeye L, Raedt R, Vonck K, Meurs A, Boon P, et al. Reduced distractor interference during vagus nerve stimulation. INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY. 2018;128:93–9.
MLA
van Bochove, Marlies, Leen De Taeye, Robrecht Raedt, et al. “Reduced Distractor Interference During Vagus Nerve Stimulation.” INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY 128 (2018): 93–99. Print.
@article{8566500,
  abstract     = {Suppressing irrelevant information in decision making is an essential everyday skill. We studied whether this ability could be improved in epileptic patients during vagus nerve stimulation (VNS). VNS is known to increase norepinephrine (NE) in the brain. NE is thought to improve several aspects of cognitive control, including the suppression of irrelevant information. Nineteen epileptic VNS patients executed the Eriksen flanker task twice, both during on and off stimulation. Distractor interference was indexed by the congruency effect, a standard empirical marker of cognitive control. We found a reduced congruency effect during stimulation, which indicates an improved ability to suppress distractor interference. This effect was only found in patients that are clinically determined VNS-responders (n = 10). As VNS increases NE in VNS-responders, our finding suggests a beneficial role of NE in cognitive control. At the same time, it suggests that VNS does not only reduce seizure frequency in epileptic patients, but also improves cognitive control.},
  author       = {van Bochove, Marlies and De Taeye, Leen and Raedt, Robrecht and Vonck, Kristl and Meurs, Alfred and Boon, Paul and Dauwe, Ine and Notebaert, Wim and Verguts, Tom},
  issn         = {0167-8760},
  journal      = {INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY},
  keyword      = {THERAPY-RESISTANT EPILEPSY,LOCUS-COERULEUS LESIONS,COGNITIVE CONTROL,REFRACTORY EPILEPSY,PREFRONTAL CORTEX,NORADRENERGIC MODULATION,INDIVIDUAL-DIFFERENCES,ALZHEIMERS-DISEASE,ANTERIOR CINGULATE,HUMAN,NEOCORTEX,Cognitive control,Congruency effect,Vagus nerve stimulation (VNS),Norepinephrine (NE),Epilepsy},
  language     = {eng},
  pages        = {93--99},
  title        = {Reduced distractor interference during vagus nerve stimulation},
  url          = {http://dx.doi.org/10.1016/j.ijpsycho.2018.03.015},
  volume       = {128},
  year         = {2018},
}

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