Advanced search
1 file | 556.51 KB

Defense mechanisms against viral infection in Drosophila : RNAi and non-RNAi

(2018) VIRUSES-BASEL. 10(5).
Author
Organization
Abstract
RNAi is considered a major antiviral defense mechanism in insects, but its relative importance as compared to other antiviral pathways has not been evaluated comprehensively. Here, it is attempted to give an overview of the antiviral defense mechanisms in Drosophila that involve both RNAi and non-RNAi. While RNAi is considered important in most viral infections, many other pathways can exist that confer antiviral resistance. It is noted that very few direct recognition mechanisms of virus infections have been identified in Drosophila and that the activation of immune pathways may be accomplished indirectly through cell damage incurred by viral replication. In several cases, protection against viral infection can be obtained in RNAi mutants by non-RNAi mechanisms, confirming the variability of the RNAi defense mechanism according to the type of infection and the physiological status of the host. This analysis is aimed at more systematically investigating the relative contribution of RNAi in the antiviral response and more specifically, to ask whether RNAi efficiency is affected when other defense mechanisms predominate. While Drosophila can function as a useful model, this issue may be more critical for economically important insects that are either controlled (agricultural pests and vectors of diseases) or protected from parasite infection (beneficial insects as bees) by RNAi products.
Keywords
insect, RNAi, non-RNAi, defense systems, antiviral, insect pest control, FLOCK HOUSE VIRUS, DOUBLE-STRANDED-RNA, MEDIATED ANTIVIRAL PROTECTION, ENDOGENOUS SIRNA PATHWAY, CRICKET PARALYSIS VIRUS, IMMUNE-RESPONSE, INNATE IMMUNITY, SINDBIS VIRUS, SIGMA-VIRUS, METHYLTRANSFERASE DNMT2

Downloads

  • viruses-10-00230.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 556.51 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Swevers, Luc, Jisheng Liu, and Guy Smagghe. 2018. “Defense Mechanisms Against Viral Infection in Drosophila : RNAi and non-RNAi.” Viruses-basel 10 (5).
APA
Swevers, Luc, Liu, J., & Smagghe, G. (2018). Defense mechanisms against viral infection in Drosophila : RNAi and non-RNAi. VIRUSES-BASEL, 10(5).
Vancouver
1.
Swevers L, Liu J, Smagghe G. Defense mechanisms against viral infection in Drosophila : RNAi and non-RNAi. VIRUSES-BASEL. 2018;10(5).
MLA
Swevers, Luc, Jisheng Liu, and Guy Smagghe. “Defense Mechanisms Against Viral Infection in Drosophila : RNAi and non-RNAi.” VIRUSES-BASEL 10.5 (2018): n. pag. Print.
@article{8565849,
  abstract     = {RNAi is considered a major antiviral defense mechanism in insects, but its relative importance as compared to other antiviral pathways has not been evaluated comprehensively. Here, it is attempted to give an overview of the antiviral defense mechanisms in Drosophila that involve both RNAi and non-RNAi. While RNAi is considered important in most viral infections, many other pathways can exist that confer antiviral resistance. It is noted that very few direct recognition mechanisms of virus infections have been identified in Drosophila and that the activation of immune pathways may be accomplished indirectly through cell damage incurred by viral replication. In several cases, protection against viral infection can be obtained in RNAi mutants by non-RNAi mechanisms, confirming the variability of the RNAi defense mechanism according to the type of infection and the physiological status of the host. This analysis is aimed at more systematically investigating the relative contribution of RNAi in the antiviral response and more specifically, to ask whether RNAi efficiency is affected when other defense mechanisms predominate. While Drosophila can function as a useful model, this issue may be more critical for economically important insects that are either controlled (agricultural pests and vectors of diseases) or protected from parasite infection (beneficial insects as bees) by RNAi products.},
  articleno    = {230},
  author       = {Swevers, Luc and Liu, Jisheng and Smagghe, Guy},
  issn         = {1999-4915},
  journal      = {VIRUSES-BASEL},
  keywords     = {insect,RNAi,non-RNAi,defense systems,antiviral,insect pest control,FLOCK HOUSE VIRUS,DOUBLE-STRANDED-RNA,MEDIATED ANTIVIRAL PROTECTION,ENDOGENOUS SIRNA PATHWAY,CRICKET PARALYSIS VIRUS,IMMUNE-RESPONSE,INNATE IMMUNITY,SINDBIS VIRUS,SIGMA-VIRUS,METHYLTRANSFERASE DNMT2},
  language     = {eng},
  number       = {5},
  pages        = {35},
  title        = {Defense mechanisms against viral infection in Drosophila : RNAi and non-RNAi},
  url          = {http://dx.doi.org/10.3390/v10050230},
  volume       = {10},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: