Advanced search
1 file | 833.68 KB

Inflammasome-dependent cytokines at the crossroads of health and autoinflammatory disease

Hanne Van Gorp (UGent) , Nina Van Opdenbosch (UGent) and Mohamed Lamkanfi (UGent)
Author
Organization
Abstract
As key regulators of both innate and adaptive immunity, it is unsurprising that the activity of interleukin (IL)-1 cytokine family members is tightly controlled by decoy receptors, antagonists, and a variety of other mechanisms. Additionally, inflammasome-mediated proteolytic maturation is a prominent and distinguishing feature of two important members of this cytokine family, IL-1β and IL-18, because their full-length gene products are biologically inert. Although vital in antimicrobial host defense, deregulated inflammasome signaling is linked with a growing number of autoimmune and autoinflammatory diseases. Here, we focus on introducing the diverse inflammasome types and discussing their causal roles in periodic fever syndromes. Therapies targeting IL-1 or IL-18 show great efficacy in some of these autoinflammatory diseases, although further understanding of the molecular mechanisms leading to unregulated production of these key cytokines is required to benefit more patients.

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 833.68 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Van Gorp, Hanne, Nina Van Opdenbosch, and Mohamed Lamkanfi. 2018. “Inflammasome-dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease.” Cold Spring Harbor Perspectives in Biology.
APA
Van Gorp, H., Van Opdenbosch, N., & Lamkanfi, M. (2018). Inflammasome-dependent cytokines at the crossroads of health and autoinflammatory disease. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY.
Vancouver
1.
Van Gorp H, Van Opdenbosch N, Lamkanfi M. Inflammasome-dependent cytokines at the crossroads of health and autoinflammatory disease. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2018;
MLA
Van Gorp, Hanne, Nina Van Opdenbosch, and Mohamed Lamkanfi. “Inflammasome-dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease.” COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018): n. pag. Print.
@article{8564408,
  abstract     = {As key regulators of both innate and adaptive immunity, it is unsurprising that the activity of interleukin (IL)-1 cytokine family members is tightly controlled by decoy receptors, antagonists, and a variety of other mechanisms. Additionally, inflammasome-mediated proteolytic maturation is a prominent and distinguishing feature of two important members of this cytokine family, IL-1\ensuremath{\beta} and IL-18, because their full-length gene products are biologically inert. Although vital in antimicrobial host defense, deregulated inflammasome signaling is linked with a growing number of autoimmune and autoinflammatory diseases. Here, we focus on introducing the diverse inflammasome types and discussing their causal roles in periodic fever syndromes. Therapies targeting IL-1 or IL-18 show great efficacy in some of these autoinflammatory diseases, although further understanding of the molecular mechanisms leading to unregulated production of these key cytokines is required to benefit more patients.},
  author       = {Van Gorp, Hanne and Van Opdenbosch, Nina and Lamkanfi, Mohamed},
  issn         = {1943-0264},
  journal      = {COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY},
  language     = {eng},
  title        = {Inflammasome-dependent cytokines at the crossroads of health and autoinflammatory disease},
  url          = {http://dx.doi.org/10.1101/cshperspect.a028563},
  year         = {2018},
}

Altmetric
View in Altmetric