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The unfolded protein response in the immune cell development : putting the caretaker in the driving seat

Simon Tavernier (UGent) , Bart Lambrecht (UGent) and Sophie Janssens (UGent)
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Abstract
The endoplasmic reticulum (ER) is the primary site for the folding of proteins destined for the membranous compartment and the extracellular space. This elaborate function is coordinated by the unfolded protein response (UPR), a stress-activated cellular program that governs proteostasis. In multicellular organisms, cells have adopted specialized functions, which required functional adaptations of the ER and its UPR. Recently, it has become clear that in immune cells, the UPR has acquired functions that stretch far beyond its original scope. In this review, we will discuss the role of the UPR in the immune system and highlight the plasticity of this signaling cascade throughout immune cell development .

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Chicago
Tavernier, Simon, Bart Lambrecht, and Sophie Janssens. 2018. “The Unfolded Protein Response in the Immune Cell Development : Putting the Caretaker in the Driving Seat.” In Coordinating Organismal Physiology Through the Unfolded Protein Response, ed. R Luke Wiseman and Cole M Haynes, 414:45–72. Cham, Switzerland: Springer.
APA
Tavernier, Simon, Lambrecht, B., & Janssens, S. (2018). The unfolded protein response in the immune cell development : putting the caretaker in the driving seat. In R. L. Wiseman & C. M. Haynes (Eds.), Coordinating organismal physiology through the unfolded protein response (Vol. 414, pp. 45–72). Cham, Switzerland: Springer.
Vancouver
1.
Tavernier S, Lambrecht B, Janssens S. The unfolded protein response in the immune cell development : putting the caretaker in the driving seat. In: Wiseman RL, Haynes CM, editors. Coordinating organismal physiology through the unfolded protein response. Cham, Switzerland: Springer; 2018. p. 45–72.
MLA
Tavernier, Simon, Bart Lambrecht, and Sophie Janssens. “The Unfolded Protein Response in the Immune Cell Development : Putting the Caretaker in the Driving Seat.” Coordinating Organismal Physiology Through the Unfolded Protein Response. Ed. R Luke Wiseman & Cole M Haynes. Vol. 414. Cham, Switzerland: Springer, 2018. 45–72. Print.
@incollection{8564397,
  abstract     = {The endoplasmic reticulum (ER) is the primary site for the folding of proteins destined for the membranous compartment and the extracellular space. This elaborate function is coordinated by the unfolded protein response (UPR), a stress-activated cellular program that governs proteostasis. In multicellular organisms, cells have adopted specialized functions, which required functional adaptations of the ER and its UPR. Recently, it has become clear that in immune cells, the UPR has acquired functions that stretch far beyond its original scope. In this review, we will discuss the role of the UPR in the immune system and highlight the plasticity of this signaling cascade throughout immune cell development .},
  author       = {Tavernier, Simon and Lambrecht, Bart and Janssens, Sophie},
  booktitle    = {Coordinating organismal physiology through the unfolded protein response},
  editor       = {Wiseman, R Luke and Haynes, Cole M},
  isbn         = {9783319785295},
  issn         = {0070-217X},
  language     = {eng},
  pages        = {45--72},
  publisher    = {Springer},
  series       = {Current Topics in Microbiology and Immunology},
  title        = {The unfolded protein response in the immune cell development : putting the caretaker in the driving seat},
  url          = {http://dx.doi.org/10.1007/82\_2017\_1},
  volume       = {414},
  year         = {2018},
}

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