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Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis

(2018) JOURNAL OF DAIRY SCIENCE. 101(4). p.3311-3322
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Abstract
The main objectives of this study were to quantify the consumption of antimicrobials on a convenience sample of dairy herds and to determine the association between herd-level antimicrobial consumption and inhibition zone diameters (IZD) of non-aureus staphylococci and Staphylococcus aureus isolates from subclinical mastitis cases. Also, the association between the IZD of non-aureus staphylococci and Staph. aureus isolates within a herd was studied. Antimicrobial consumption data on 56 Flemish dairy farms were obtained between 2013 and 2014 by so-called garbage can audits and expressed as antimicrobial treatment incidence (ATI), with the unit of ATI being the number of defined daily doses animal (DDDA) used per 1,000 cow-days. The average total ATI in adult dairy cattle for all active substances was 18.73 DDDA per 1,000 cow-days and ranged from 6.28 to 42.13 DDDA between herds. The ATI of critically important (for human health) antimicrobials was 6.91 DDDA per 1,000 cow-days; that is, 37% of total antimicrobial consumption. The average ATI for intramammary therapy of (sub) clinical mastitis, intramammary dry-cow therapy, and systemically administered therapy was 5.20, 6.70, and 6.73 DDDA, respectively. The IZD of 239 non-aureus staphylococci and 88 Staph. aureus isolates originating from milk samples from cows with subclinical mastitis collected on selected dairy herds were determined using Kirby-Bauer disk diffusion and ranged between 6 and 42 mm. Because only a limited number of clinical breakpoints (Clinical and Laboratory Standards Institute) and epidemiological cut-off values (European Committee on Antimicrobial Susceptibility Testing) are available for mastitis-causing bacteria in bovine, IZD were used as a proxy for antimicrobial resistance. Inhibition zone diameters of non-aureus staphylococci for cefquinome, a critically important beta-lactam antibiotic, were negatively associated with the ATI of critically important beta-lactam for systemically administered therapy and positively with the ATI for intramammary therapy of (sub) clinical mastitis of critically important beta-lactam antimicrobials. Only for neomycin was a positive association between the IZD of non-aureus staphylococci and Staph. aureus isolates within the same herd observed.
Keywords
antimicrobial consumption, staphylococci, subclinical mastitis, inhibition zone diameters, COAGULASE-NEGATIVE STAPHYLOCOCCI, BOVINE MASTITIS, RISK-FACTORS, ANTIBIOTIC SUSCEPTIBILITY, INTRAMAMMARY INFECTIONS, DRUG USAGE, PREVALENCE, RESISTANCE, PATHOGENS, FARMS

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MLA
Stevens, Marina et al. “Antimicrobial Consumption on Dairy Herds and Its Association with Antimicrobial Inhibition Zone Diameters of Non-aureus Staphylococci and Staphylococcus Aureus Isolated from Subclinical Mastitis.” JOURNAL OF DAIRY SCIENCE 101.4 (2018): 3311–3322. Print.
APA
Stevens, M., Piepers, S., Supré, K., & De Vliegher, S. (2018). Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis. JOURNAL OF DAIRY SCIENCE, 101(4), 3311–3322.
Chicago author-date
Stevens, Marina, Sofie Piepers, Karlien Supré, and Sarne De Vliegher. 2018. “Antimicrobial Consumption on Dairy Herds and Its Association with Antimicrobial Inhibition Zone Diameters of Non-aureus Staphylococci and Staphylococcus Aureus Isolated from Subclinical Mastitis.” Journal of Dairy Science 101 (4): 3311–3322.
Chicago author-date (all authors)
Stevens, Marina, Sofie Piepers, Karlien Supré, and Sarne De Vliegher. 2018. “Antimicrobial Consumption on Dairy Herds and Its Association with Antimicrobial Inhibition Zone Diameters of Non-aureus Staphylococci and Staphylococcus Aureus Isolated from Subclinical Mastitis.” Journal of Dairy Science 101 (4): 3311–3322.
Vancouver
1.
Stevens M, Piepers S, Supré K, De Vliegher S. Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis. JOURNAL OF DAIRY SCIENCE. 2018;101(4):3311–22.
IEEE
[1]
M. Stevens, S. Piepers, K. Supré, and S. De Vliegher, “Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis,” JOURNAL OF DAIRY SCIENCE, vol. 101, no. 4, pp. 3311–3322, 2018.
@article{8564041,
  abstract     = {The main objectives of this study were to quantify the consumption of antimicrobials on a convenience sample of dairy herds and to determine the association between herd-level antimicrobial consumption and inhibition zone diameters (IZD) of non-aureus staphylococci and Staphylococcus aureus isolates from subclinical mastitis cases. Also, the association between the IZD of non-aureus staphylococci and Staph. aureus isolates within a herd was studied. Antimicrobial consumption data on 56 Flemish dairy farms were obtained between 2013 and 2014 by so-called garbage can audits and expressed as antimicrobial treatment incidence (ATI), with the unit of ATI being the number of defined daily doses animal (DDDA) used per 1,000 cow-days. The average total ATI in adult dairy cattle for all active substances was 18.73 DDDA per 1,000 cow-days and ranged from 6.28 to 42.13 DDDA between herds. The ATI of critically important (for human health) antimicrobials was 6.91 DDDA per 1,000 cow-days; that is, 37% of total antimicrobial consumption. The average ATI for intramammary therapy of (sub) clinical mastitis, intramammary dry-cow therapy, and systemically administered therapy was 5.20, 6.70, and 6.73 DDDA, respectively. The IZD of 239 non-aureus staphylococci and 88 Staph. aureus isolates originating from milk samples from cows with subclinical mastitis collected on selected dairy herds were determined using Kirby-Bauer disk diffusion and ranged between 6 and 42 mm. Because only a limited number of clinical breakpoints (Clinical and Laboratory Standards Institute) and epidemiological cut-off values (European Committee on Antimicrobial Susceptibility Testing) are available for mastitis-causing bacteria in bovine, IZD were used as a proxy for antimicrobial resistance. Inhibition zone diameters of non-aureus staphylococci for cefquinome, a critically important beta-lactam antibiotic, were negatively associated with the ATI of critically important beta-lactam for systemically administered therapy and positively with the ATI for intramammary therapy of (sub) clinical mastitis of critically important beta-lactam antimicrobials. Only for neomycin was a positive association between the IZD of non-aureus staphylococci and Staph. aureus isolates within the same herd observed.},
  author       = {Stevens, Marina and Piepers, Sofie and Supré, Karlien and De Vliegher, Sarne},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keywords     = {antimicrobial consumption,staphylococci,subclinical mastitis,inhibition zone diameters,COAGULASE-NEGATIVE STAPHYLOCOCCI,BOVINE MASTITIS,RISK-FACTORS,ANTIBIOTIC SUSCEPTIBILITY,INTRAMAMMARY INFECTIONS,DRUG USAGE,PREVALENCE,RESISTANCE,PATHOGENS,FARMS},
  language     = {eng},
  number       = {4},
  pages        = {3311--3322},
  title        = {Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis},
  url          = {http://dx.doi.org/10.3168/jds.2017-13365},
  volume       = {101},
  year         = {2018},
}

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