Advanced search
1 file | 188.14 KB

Clinical burden of hepatitis E virus infection in a tertiary care center in Flanders, Belgium

Lien Cattoir (UGent) , FREDERIK VAN HOECKE (UGent) , Tom Van Maerken (UGent) , Eline Nys, Inge Ryckaert (UGent) , Matthias De Boulle (UGent) , Anja Geerts (UGent) , Xavier Verhelst (UGent) , Isabelle Colle (UGent) , Veronik Hutse, et al.
Author
Organization
Abstract
Background: Hepatitis E virus (HEV) infection is increasingly recognized as a cause of hepatitis in developed countries. A high HEV IgG seroprevalence in humans and pigs is reported as well as sporadic clinical cases of autochtonous HEV but there are currently no data available on the clinical burden of HEV in Belgium. Objectives: The objective of the current study was to evaluate the actual clinical burden of HEV infections in our tertiary care center in Flanders, Belgium. Study design: In the setting of Ghent University Hospital, patients were assessed for the presence of HEV IgG and IgM as well as HEV RNA if no other cause was found for one of the following clinical presentations: a) elevation of liver enzymes in post-liver transplant; b) suspicion of acute or toxic hepatitis; c) unexplainable elevation of liver enzymes; d) cirrhosis with acute-on-chronic exacerbation. Results: In a period of 39 months (January 2011-April 2014) 71 patients were enrolled. HEV IgG was found positive in 13 (18,3%) patients; HEV IgM in 6 patients (8,5%) and HEV RNA in 4 (5,6%) patients. All HEV IgM/ RNA positive patients were male, aged 41-63, and classified in the clinical groups a), b) or d). HEV IgG seroprevalence was slightly higher but not significantly different from the seroprevalence in the general population in this region in Belgium previously reported to be 14% (p-value 0.41) by our group. Conclusions: HEV should be considered as a cause of liver pathology especially in middle-aged men with elevation of liver enzymes.
Keywords
Hepatitis E virus, Clinical impact, Belgium, EMERGING INFECTION, COUNTRIES, SEROPREVALENCE, DISEASE, SWINE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 188.14 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Cattoir, Lien, FREDERIK VAN HOECKE, Tom Van Maerken, Eline Nys, Inge Ryckaert, Matthias De Boulle, Anja Geerts, et al. 2018. “Clinical Burden of Hepatitis E Virus Infection in a Tertiary Care Center in Flanders, Belgium.” Journal of Clinical Virology 103: 8–11.
APA
Cattoir, Lien, VAN HOECKE, F., Van Maerken, T., Nys, E., Ryckaert, I., De Boulle, M., Geerts, A., et al. (2018). Clinical burden of hepatitis E virus infection in a tertiary care center in Flanders, Belgium. JOURNAL OF CLINICAL VIROLOGY, 103, 8–11.
Vancouver
1.
Cattoir L, VAN HOECKE F, Van Maerken T, Nys E, Ryckaert I, De Boulle M, et al. Clinical burden of hepatitis E virus infection in a tertiary care center in Flanders, Belgium. JOURNAL OF CLINICAL VIROLOGY. 2018;103:8–11.
MLA
Cattoir, Lien, FREDERIK VAN HOECKE, Tom Van Maerken, et al. “Clinical Burden of Hepatitis E Virus Infection in a Tertiary Care Center in Flanders, Belgium.” JOURNAL OF CLINICAL VIROLOGY 103 (2018): 8–11. Print.
@article{8563886,
  abstract     = {Background: Hepatitis E virus (HEV) infection is increasingly recognized as a cause of hepatitis in developed countries. A high HEV IgG seroprevalence in humans and pigs is reported as well as sporadic clinical cases of autochtonous HEV but there are currently no data available on the clinical burden of HEV in Belgium. 
Objectives: The objective of the current study was to evaluate the actual clinical burden of HEV infections in our tertiary care center in Flanders, Belgium. 
Study design: In the setting of Ghent University Hospital, patients were assessed for the presence of HEV IgG and IgM as well as HEV RNA if no other cause was found for one of the following clinical presentations: a) elevation of liver enzymes in post-liver transplant; b) suspicion of acute or toxic hepatitis; c) unexplainable elevation of liver enzymes; d) cirrhosis with acute-on-chronic exacerbation. 
Results: In a period of 39 months (January 2011-April 2014) 71 patients were enrolled. HEV IgG was found positive in 13 (18,3\%) patients; HEV IgM in 6 patients (8,5\%) and HEV RNA in 4 (5,6\%) patients. All HEV IgM/ RNA positive patients were male, aged 41-63, and classified in the clinical groups a), b) or d). HEV IgG seroprevalence was slightly higher but not significantly different from the seroprevalence in the general population in this region in Belgium previously reported to be 14\% (p-value 0.41) by our group. 
Conclusions: HEV should be considered as a cause of liver pathology especially in middle-aged men with elevation of liver enzymes.},
  author       = {Cattoir, Lien and VAN HOECKE, FREDERIK and Van Maerken, Tom and Nys, Eline and Ryckaert, Inge and De Boulle, Matthias and Geerts, Anja and Verhelst, Xavier and Colle, Isabelle and Hutse, Veronik and Suin, Vanessa and Wauthier, Magali and Van Gucht, Steven and Van Vlierberghe, Hans and Padalko, Elizaveta},
  issn         = {1386-6532},
  journal      = {JOURNAL OF CLINICAL VIROLOGY},
  keyword      = {Hepatitis E virus,Clinical impact,Belgium,EMERGING INFECTION,COUNTRIES,SEROPREVALENCE,DISEASE,SWINE},
  language     = {eng},
  pages        = {8--11},
  title        = {Clinical burden of hepatitis E virus infection in a tertiary care center in Flanders, Belgium},
  url          = {http://dx.doi.org/10.1016/j.jcv.2018.03.004},
  volume       = {103},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: