Clinical presentation, diagnostic findings and outcome in dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin
- Author
- Ine Cornelis (UGent) , HA Volk, Luc Van Ham (UGent) and Steven De Decker
- Organization
- Abstract
- Objectives: To summarise clinical presentation, diagnostic findings and long-term outcome for dogs clinically diagnosed with meningoencephalomyelitis of unknown origin affecting the spinal cord alone. Methods: Medical records were reviewed for dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin between 2006 and 2015. Results: 21 dogs were included; the majority presented with an acute (43%) or chronic (52%) onset of neurological signs. Ambulatory paresis was the most common neurological presentation (67%). Neurological examination most commonly revealed a T3-L3 myelopathy, and spinal hyperaesthesia was a common finding (71%). A spinal cord lesion was visible in 90% of cases on magnetic resonance imaging. Eighteen lesions (86%) showed parenchymal contrast enhancement and 17 lesions (81%) showed contrast enhancement of overlying meninges. All dogs were treated with immunosuppressive doses of glucocorticosteroids, sometimes combined with cytosine arabinoside. At time of data capture, 10/21 dogs (48%) had died or been euthanased because of the condition. Overall median survival time was 669 days. Clinical Significance: Meningoencephalomyelitis of unknown origin should be considered in the differential diagnosis of dogs presenting with a progressive myelopathy. Magnetic resonance imaging features can possibly help to distinguish presumptive meningoencephalomyelitis of unknown origin from other more common spinal diseases. Overall, long-term survival is guarded, approximately 50% of dogs will die or be euthanased despite appropriate therapy.
- Keywords
- MENINGOMYELITIS, DISEASE
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8563619
- MLA
- Cornelis, Ine, et al. “Clinical Presentation, Diagnostic Findings and Outcome in Dogs Diagnosed with Presumptive Spinal-Only Meningoencephalomyelitis of Unknown Origin.” JOURNAL OF SMALL ANIMAL PRACTICE, vol. 58, no. 3, 2017, pp. 174–82, doi:10.1111/jsap.12622.
- APA
- Cornelis, I., Volk, H., Van Ham, L., & De Decker, S. (2017). Clinical presentation, diagnostic findings and outcome in dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin. JOURNAL OF SMALL ANIMAL PRACTICE, 58(3), 174–182. https://doi.org/10.1111/jsap.12622
- Chicago author-date
- Cornelis, Ine, HA Volk, Luc Van Ham, and Steven De Decker. 2017. “Clinical Presentation, Diagnostic Findings and Outcome in Dogs Diagnosed with Presumptive Spinal-Only Meningoencephalomyelitis of Unknown Origin.” JOURNAL OF SMALL ANIMAL PRACTICE 58 (3): 174–82. https://doi.org/10.1111/jsap.12622.
- Chicago author-date (all authors)
- Cornelis, Ine, HA Volk, Luc Van Ham, and Steven De Decker. 2017. “Clinical Presentation, Diagnostic Findings and Outcome in Dogs Diagnosed with Presumptive Spinal-Only Meningoencephalomyelitis of Unknown Origin.” JOURNAL OF SMALL ANIMAL PRACTICE 58 (3): 174–182. doi:10.1111/jsap.12622.
- Vancouver
- 1.Cornelis I, Volk H, Van Ham L, De Decker S. Clinical presentation, diagnostic findings and outcome in dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin. JOURNAL OF SMALL ANIMAL PRACTICE. 2017;58(3):174–82.
- IEEE
- [1]I. Cornelis, H. Volk, L. Van Ham, and S. De Decker, “Clinical presentation, diagnostic findings and outcome in dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin,” JOURNAL OF SMALL ANIMAL PRACTICE, vol. 58, no. 3, pp. 174–182, 2017.
@article{8563619, abstract = {{Objectives: To summarise clinical presentation, diagnostic findings and long-term outcome for dogs clinically diagnosed with meningoencephalomyelitis of unknown origin affecting the spinal cord alone. Methods: Medical records were reviewed for dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin between 2006 and 2015. Results: 21 dogs were included; the majority presented with an acute (43%) or chronic (52%) onset of neurological signs. Ambulatory paresis was the most common neurological presentation (67%). Neurological examination most commonly revealed a T3-L3 myelopathy, and spinal hyperaesthesia was a common finding (71%). A spinal cord lesion was visible in 90% of cases on magnetic resonance imaging. Eighteen lesions (86%) showed parenchymal contrast enhancement and 17 lesions (81%) showed contrast enhancement of overlying meninges. All dogs were treated with immunosuppressive doses of glucocorticosteroids, sometimes combined with cytosine arabinoside. At time of data capture, 10/21 dogs (48%) had died or been euthanased because of the condition. Overall median survival time was 669 days. Clinical Significance: Meningoencephalomyelitis of unknown origin should be considered in the differential diagnosis of dogs presenting with a progressive myelopathy. Magnetic resonance imaging features can possibly help to distinguish presumptive meningoencephalomyelitis of unknown origin from other more common spinal diseases. Overall, long-term survival is guarded, approximately 50% of dogs will die or be euthanased despite appropriate therapy.}}, author = {{Cornelis, Ine and Volk, HA and Van Ham, Luc and De Decker, Steven}}, issn = {{0022-4510}}, journal = {{JOURNAL OF SMALL ANIMAL PRACTICE}}, keywords = {{MENINGOMYELITIS,DISEASE}}, language = {{eng}}, number = {{3}}, pages = {{174--182}}, title = {{Clinical presentation, diagnostic findings and outcome in dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin}}, url = {{http://doi.org/10.1111/jsap.12622}}, volume = {{58}}, year = {{2017}}, }
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