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Animal models to study hepatitis C virus infection

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Abstract
With more than 71 million chronically infected people, the hepatitis C virus (HCV) is a major global health concern. Although new direct acting antivirals have significantly improved the rate of HCV cure, high therapy cost, potential emergence of drug-resistant viral variants, and unavailability of a protective vaccine represent challenges for complete HCV eradication. Relevant animal models are required, and additional development remains necessary, to effectively study HCV biology, virus-host interactions and for the evaluation of new antiviral approaches and prophylactic vaccines. The chimpanzee, the only non-human primate susceptible to experimental HCV infection, has been used extensively to study HCV infection, particularly to analyze the innate and adaptive immune response upon infection. However, financial, practical, and especially ethical constraints have urged the exploration of alternative small animal models. These include different types of transgenic mice, immunodeficient mice of which the liver is engrafted with human hepatocytes (humanized mice) and, more recently, immunocompetent rodents that are susceptible to infection with viruses that are closely related to HCV. In this review, we provide an overview of the currently available animal models that have proven valuable for the study of HCV, and discuss their main benefits and weaknesses.
Keywords
hepatitis C virus, animal models, humanized mice, homologs, vaccine, antiviral therapy, HUMANIZED MOUSE MODEL, PLASMODIUM-FALCIPARUM INFECTION, CHIMERIC HUMAN LIVERS, TYROSINEMIA TYPE-I, T-CELL RESPONSES, UPA-SCID MOUSE, B TYPE-I, TRANSGENIC MICE, HUMAN HEPATOCYTES, HEPATOCELLULAR-CARCINOMA

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Citation

Please use this url to cite or link to this publication:

Chicago
Burm, Rani, Laura Collignon, Ahmed Atef Ahmed Abouzeid Mesalam, and Philip Meuleman. 2018. “Animal Models to Study Hepatitis C Virus Infection.” Ed. Steven Foung. Frontiers in Immunology 9.
APA
Burm, R., Collignon, L., Mesalam, A. A. A. A., & Meuleman, P. (2018). Animal models to study hepatitis C virus infection. (S. Foung, Ed.)FRONTIERS IN IMMUNOLOGY, 9.
Vancouver
1.
Burm R, Collignon L, Mesalam AAAA, Meuleman P. Animal models to study hepatitis C virus infection. Foung S, editor. FRONTIERS IN IMMUNOLOGY. 2018;9.
MLA
Burm, Rani, Laura Collignon, Ahmed Atef Ahmed Abouzeid Mesalam, et al. “Animal Models to Study Hepatitis C Virus Infection.” Ed. Steven Foung. FRONTIERS IN IMMUNOLOGY 9 (2018): n. pag. Print.
@article{8562864,
  abstract     = {With more than 71 million chronically infected people, the hepatitis C virus (HCV) is a major global health concern. Although new direct acting antivirals have significantly improved the rate of HCV cure, high therapy cost, potential emergence of drug-resistant viral variants, and unavailability of a protective vaccine represent challenges for complete HCV eradication. Relevant animal models are required, and additional development remains necessary, to effectively study HCV biology, virus-host interactions and for the evaluation of new antiviral approaches and prophylactic vaccines. The chimpanzee, the only non-human primate susceptible to experimental HCV infection, has been used extensively to study HCV infection, particularly to analyze the innate and adaptive immune response upon infection. However, financial, practical, and especially ethical constraints have urged the exploration of alternative small animal models. These include different types of transgenic mice, immunodeficient mice of which the liver is engrafted with human hepatocytes (humanized mice) and, more recently, immunocompetent rodents that are susceptible to infection with viruses that are closely related to HCV. In this review, we provide an overview of the currently available animal models that have proven valuable for the study of HCV, and discuss their main benefits and weaknesses.},
  articleno    = {1032},
  author       = {Burm, Rani and Collignon, Laura and Mesalam, Ahmed Atef Ahmed Abouzeid and Meuleman, Philip},
  editor       = {Foung, Steven},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keyword      = {hepatitis C virus,animal models,humanized mice,homologs,vaccine,antiviral therapy,HUMANIZED MOUSE MODEL,PLASMODIUM-FALCIPARUM INFECTION,CHIMERIC HUMAN LIVERS,TYROSINEMIA TYPE-I,T-CELL RESPONSES,UPA-SCID MOUSE,B TYPE-I,TRANSGENIC MICE,HUMAN HEPATOCYTES,HEPATOCELLULAR-CARCINOMA},
  language     = {eng},
  pages        = {15},
  title        = {Animal models to study hepatitis C virus infection},
  url          = {http://dx.doi.org/10.3389/fimmu.2018.01032},
  volume       = {9},
  year         = {2018},
}

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